Patent number: 5807535
Abstract: A physiologically acceptable, radiolabelled compound of general formula (I) consisting of a compound of the ##STR1## where k is an integer from 2 to 5l is an integer from 1 to 5X and Y are independently selected from phenyl, naphthyl, pyridine or quinoline radical, each having at position 2 one of --OH, --SH, --NH.sub.2 or --COOH and each of X and Y can be optionally substituted by one or more amino, halogen, hydroxy, mercapto, nitro, cyano, thiocyano, alkyl, alkoxy, halogenoalkyl, acyl, acylamino, acyloxy, carboxyl, alkoxycarbonyl, carbamoyl, pyridoylamino, N-carboxyalkyl-carbamoyl, sulpho, sulphamoyl, mono- or dialkylated or phenylated sulphamoyl which can also carry one or more substituents R', alkylsulphonyl, alkoxysulphonyl, or by an optionally hydroxy-containing phenylsulphonyl or phenoxysulphonyl; where R' is as defined for X and Y; or pharmaceutically acceptable salts thereof.
Type:
Grant
Filed:
December 15, 1995
Date of Patent:
September 15, 1998
Assignee:
Australian Nuclear Science & Technology Organisation
Inventors:
Suzanne V. Smith, Richard M. Lambrecht, Peter F. Schmidt, Fook-Thean Lee, Therese M. Donlevy, Nadine M. Di Bartolo
Patent number: 5550160
Abstract: A physiologically acceptable, radiolabelled compound of general formula ##STR1## where k is an integer from 2 to 5l is an integer from 1 to 5X and Y are independently selected from phenyl or naphthyl radical each of which can be substituted by one or more amino, mono- or di- substituted amino, halogen, hydroxy, mercapto, nitro, cyano, thiocyano, alkyl, alkoxy, halogenoalkyl, acyl, acylamino, acyloxy, carboxyl, alkoxycarbonyl, carbamoyl, pyridoylamino, N-carboxyalkyl-carbamoyl, sulpho, sulphamoyl, mono- or dialkylated or phenylated sulphamoyl which can also carry one or more substituents R', alkylsulphonyl, alkoxysulphonyl, --(CH.sub.2).sub.p NHCOR", --COR" or by an optionally hydroxy-containing phenylsulphonyl or phenoxysulphonyl; or X and Y are independently selected from pyridine or quinoline radical each of which can be substituted by amine, halogen, hydroxy, alkyl, or carbamoyl; where R' is as defined for X and Y; R" is alkyl-L where L is halogen or other leaving group; 2,5-diketo-pyrrolinyl, --Het--CH.
Type:
Grant
Filed:
July 29, 1993
Date of Patent:
August 27, 1996
Assignee:
Australian Nuclear Science & Technology Organization
Inventors:
Suzanne V. Smith, Richard M. Lambrecht, Peter F. Schmidt, Fook-Thean Lee