Patents by Inventor Suzette L. Pereira
Suzette L. Pereira has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 7456270Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 6 (i.e., “?6-desaturase”). In particular, ?6-desaturase may be utilized, for example, in the conversion of linoleic acid to ?-linolenic acid and in the conversion of ?-linolenic acid stearidonic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: September 1, 2004Date of Patent: November 25, 2008Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Yung-Sheng Huang, Amanda E. Leonard, Suzette L. Pereira, Jennifer M. Thurmond
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Publication number: 20080214667Abstract: The subject invention relates to the identification of a gene involved in the elongation of polyunsaturated fatty acids containing unsaturation at the carbon 9 position (i.e., “?9-elongase”) and to uses thereof. In particular, ?9-elongase may be utilized, for example, in the conversion of linoleic acid (LA, 18:2n-6) to eicosadienoic acid (EDA, 20:2n-6). The production of dihomo-?-linolenic acid (DGLA, 20:3n-6) from eicosadienoic acid (EDA, 20:2n-6), and arachidonic acid (AA, 20:4n-6) from dihomo-?-linolenic acid (DGLA, 20:3n-6) is then catalyzed by ?8-desaturase and ?5-desaturase, respectively. AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: ApplicationFiled: November 14, 2007Publication date: September 4, 2008Inventors: Tapas Das, Pradip Mukerji, Padmavathy Krishnan, Amanda E. Leonard, Suzette L. Pereira
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Publication number: 20080176944Abstract: The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to ?3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ?6-docosapentaenoic acid or ?3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: ApplicationFiled: March 12, 2008Publication date: July 24, 2008Inventors: Pradip Mukerji, Amanda Eun-Yeong Leonard, Yung-Sheng Huang, Suzette L. Pereira
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Publication number: 20080125487Abstract: The subject invention relates to the identification of a gene involved in the elongation of polyunsaturated fatty acids containing unsaturation at the carbon 9 position (i.e., “?9-elongase”) and to uses thereof. In particular, ?9-elongase may be utilized, for example, in the conversion of linoleic acid (LA, 18:2n-6) to eicosadienoic acid (EDA, 20:2n-6). The production of dihomo-?-linolenic acid (DGLA, 20:3n-6) from eicosadienoic acid (EDA, 20:2n-6), and arachidonic acid (AA, 20:4n-6) from dihomo-?-linolenic acid (DGLA, 20:3n-6) is then catalyzed by ?8-desaturase and ?5-desaturase, respectively. AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: ApplicationFiled: November 17, 2006Publication date: May 29, 2008Inventors: Tapas Das, Pradip Mukerji, Padmavathy Krishnan, Amanda E. Leonard, Suzette L. Pereira
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Patent number: 7375205Abstract: The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated fatty acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to ?3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, ?6-docosapentaenoic acid or ?3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: August 5, 2004Date of Patent: May 20, 2008Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Amanda Eun-Yeong Leonard, Yung-Sheng Huang, Suzette L Pereira
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Patent number: 7368552Abstract: The subject invention relates to isolated nucleic acid sequences or genes involved in polyketide synthase (PKS) biosynthetic pathways. In particular, such pathways are involved in the production of polyunsaturated fatty acids (PUFAs) such as, for example, Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). Specifically, the invention relates to isolating nucleic acid sequences encoding proteins involved in eukaryotic PUFA-PKS systems and to uses of these genes and encoded proteins in PUFA-PKS systems, in heterologous hosts, for the production of PUFAs such as EPA and DHA.Type: GrantFiled: February 27, 2007Date of Patent: May 6, 2008Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Suzette L. Pereira
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Patent number: 7241619Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “?5-desaturase”) and at carbon 6 (i.e., “?6-desaturase”) and to uses thereof. In particular, ?5-desaturase may be utilized, for example, in the conversion of dihomo-?-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to ?-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: May 8, 2003Date of Patent: July 10, 2007Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Yung-Sheng Huang, Tapas Das, Jennifer Thurmond, Suzette L. Pereira
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Patent number: 7220897Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., “?4-desaturase”). In particular, ?4-desaturase may be utilized, for example, in the conversion of adrenic acid to ?6-docosapentaenoic acid and in the conversion of ?3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: August 6, 2004Date of Patent: May 22, 2007Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Jennifer Thurmond, Yung-Sheng Huang, Tapas Das, Amanda Eun-Yeong Leonard, Suzette L. Pereira
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Patent number: 7211656Abstract: Disclosed are isolated polynucleotides encoding an omega-3 desaturase and a delta-12 desaturase, the enzymes encoded by the isolated polynucleotides, vectors containing the isolated polynucleotides, transgenic hosts that contain the isolated polynucleotides that express the enzymes encoded thereby, methods for producing the desaturase enzymes, and method of using the enzymes to make polyunsaturated fatty acids. The isolated polynucleotides are derived from a fungus, Saprolegnia diclina (ATCC 56851). In particular, omega-3-desaturase may be utilized, for example, in the conversion of arachidonic acid (AA) to eicosapentaenoic acid (EPA). Delta-12 desaturase may be used, for example, in the conversion of oleic acid (OA) to linoleic (LA). EPA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: January 30, 2002Date of Patent: May 1, 2007Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Suzette L. Pereira, Yung-Sheng Huang
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Patent number: 7208590Abstract: The subject invention relates to isolated nucleic acid sequences or genes involved in polyketide synthase (PKS) biosynthetic pathways. In particular, such pathways are involved in the production of polyunsaturated fatty acids (PUFAs) such as, for example, Eicosapentaenoic acid (EPA) and Docosahexaenoic acid (DHA). Specifically, the invention relates to isolating nucleic acid sequences encoding proteins involved in eukaryotic PUFA-PKS systems and to uses of these genes and encoded proteins in PUFA-PKS systems, in heterologous hosts, for the production of PUFAs such as EPA and DHA.Type: GrantFiled: July 15, 2003Date of Patent: April 24, 2007Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Suzette L. Pereira
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Patent number: 7208297Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., “?4-desaturase”). In particular, ?4-desaturase may be utilized, for example, in the conversion of adrenic acid to ?6-docosapentaenoic acid and in the conversion of ?3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: August 6, 2004Date of Patent: April 24, 2007Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Jennifer Thurmond, Yung-Sheng Huang, Tapas Das, Amanda Eun-Yeong Leonard, Suzette L. Pereira
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Patent number: 7205134Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., “?4-desaturase”). In particular, ?4-desaturase may be utilized, for example, in the conversion of adrenic acid to ?6-docosapentaenoic acid and in the conversion of ?3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: August 6, 2004Date of Patent: April 17, 2007Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Jennifer Thurmond, Yung-Sheng Huang, Tapas Das, Amanda Eun-Yeong Leonard, Suzette L. Pereira
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Patent number: 7067285Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “?5-desaturase”) and at carbon 6 (i.e., “?6-desaturase”) and to uses thereof. In particular, ?5-desaturase may be utilized, for example, in the conversion of dihomo-?-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to ?-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: January 22, 2002Date of Patent: June 27, 2006Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Yung-Sheng Huang, Tapas Das, Jennifer Thurmond, Amanda Eun-Yeong Leonard, Suzette L. Pereira
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Patent number: 7045683Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 4 (i.e., “?4-desaturase”). In particular, ?4-desaturase may be utilized, for example, in the conversion of adrenic acid to ?6-docosapentaenoic acid and in the conversion of ?3-docosapentaenoic acid to docosahexaenoic acid. The polyunsaturated fatty acids produced by use of the enzyme may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: April 11, 2002Date of Patent: May 16, 2006Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Jennifer Thurmond, Yung-Sheng Huang, Tapas Das, Amanda Eun-Yeong Leonard, Suzette L. Pereira
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Patent number: 6677145Abstract: The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to &ohgr;3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, &ohgr;6-docosapentaenoic acid or &ohgr;3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: July 11, 2001Date of Patent: January 13, 2004Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Amanda Eun-Yeong Leonard, Yung-Sheng Huang, Suzette L. Pereira
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Patent number: 6635451Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “&Dgr;5-desaturase”) and at carbon 6 (i.e., “&Dgr;6-desaturase”) and to uses thereof. In particular, &Dgr;5-desaturase may be utilized, for example, in the conversion of dihomo-&ggr;-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to &ggr;-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: GrantFiled: January 25, 2001Date of Patent: October 21, 2003Assignee: Abbott LaboratoriesInventors: Pradip Mukerji, Yung-Sheng Huang, Tapas Das, Jennifer Thurmond, Suzette L. Pereira
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Publication number: 20030196217Abstract: Disclosed are isolated polynucleotides encoding an omega-3 desaturase and a delta-12 desaturase, the enzymes encoded by the isolated polynucleotides, vectors containing the isolated polynucleotides, transgenic hosts that contain the isolated polynucleotides that express the enzymes encoded thereby, methods for producing the desaturase enzymes, and method of using the enzymes to make polyunsaturated fatty acids. The isolated polynucleotides are derived from a fungus, Saprolegnia diclina (ATCC 56851). In particular, omega-3-desaturase may be utilized, for example, in the conversion of arachidonic acid (AA) to eicosapentaenoic acid (EPA). Delta-12 desaturase may be used, for example, in the conversion of oleic acid (OA) to linoleic (LA). EPA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: ApplicationFiled: January 30, 2002Publication date: October 16, 2003Inventors: Pradip Mukerji, Suzette L. Pereira, Yung-Sheng Huang
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Publication number: 20030190733Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “&Dgr;5-desaturase”) and at carbon 6 (i.e., “&Dgr;6-desaturase”) and to uses thereof. In particular, &Dgr;5-desaturase may be utilized, for example, in the conversion of dihomo-&ggr; -linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to &ggr;-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: ApplicationFiled: May 8, 2003Publication date: October 9, 2003Inventors: Pradip Mukerji, Yung-Sheng Huang, Tapas Das, Jennifer Thurmond, Suzette L. Pereira
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Publication number: 20030167525Abstract: The subject invention relates to the identification of genes involved in the desaturation of polyunsaturated fatty acids at carbon 5 (i.e., “&Dgr;5-desaturase”) and at carbon 6 (i.e., “&Dgr;6-desaturase”) and to uses thereof. In particular, &Dgr;5-desaturase may be utilized, for example, in the conversion of dihomo-&ggr;-linolenic acid (DGLA) to arachidonic acid (AA) and in the conversion of 20:4n-3 to eicosapentaenoic acid (EPA). Delta-6 desaturase may be used, for example, in the conversion of linoleic (LA) to &ggr;-linolenic acid (GLA). AA or polyunsaturated fatty acids produced therefrom may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: ApplicationFiled: January 22, 2002Publication date: September 4, 2003Inventors: Pradip Mukerji, Yung-Sheng Huang, Tapas Das, Jennifer Thurmond, Amanda Eun-Yeong Leonard, Suzette L. Pereira
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Publication number: 20030163845Abstract: The subject invention relates to the identification of several genes involved in the elongation of polyunsaturated acids (i.e., “elongases”) and to uses thereof. At least two of these genes are also involved in the elongation of monounsaturated fatty acids. In particular, elongase is utilized in the conversion of gamma linolenic acid (GLA) to dihomogamma linolenic acid (DGLA) and in the conversion of AA to adrenic acid (ADA), or eicosapentaenoic acid (EPA) to &ohgr;3-docosapentaenoic acid (DPA). DGLA may be utilized in the production of polyunsaturated fatty acids, such as arachidonic acid (AA), docosahexaenoic acid (DHA), EPA, adrenic acid, &ohgr;6-docosapentaenoic acid or &ohgr;3-docosapentaenoic acid which may be added to pharmaceutical compositions, nutritional compositions, animal feeds, as well as other products such as cosmetics.Type: ApplicationFiled: May 29, 2002Publication date: August 28, 2003Inventors: Pradip Mukerji, Amanda Eun-Yeong Leonard, Yung-Sheng Huang, Suzette L. Pereira