Abstract: An automated method for analysing capillaries in a plurality of images acquired from a subject. The method comprising the steps of: a) acquiring the plurality of images; b) generating a plurality of capillary candidate maps for each of said images, each capillary candidate map comprising one or more regions of interest for each of said images, wherein for each image, each of the respective capillary candidate maps is generated by comparing said image to a different criterion; c) combining said capillary candidate maps to generate a combined capillary candidate map; d) using a first neural network to determine a respective location of one or more detected capillaries in said combined capillary candidate map; e) using a second neural network to determine an optical flow of said detected capillaries; and f) extracting one or more capillary parameters using said detected capillaries and/or said determined flow.

Abstract: A system for measuring haemodynamic parameters relating to a subject, the system comprising a DRS probe, a microscope probe, and a cap for use at a respective distal end of each of the probes, one at a time. The cap comprises a rigid flat contact surface for contact with a body surface of a subject, the contact surface comprising an aperture arranged such that, in use, the aperture is optically aligned with the optical probe. A rigid side wall surrounds the contact surface, defining a closed end and an open end, the closed end being formed by the contact surface. The open end is arranged to receive the probe in use. The side wall is arranged such that, in use, the cap is held in abutment against the probe. A securing portion is arranged to removably secure the cap to the probe.

Abstract: Measurement or imaging of elastic wave nonlinear scatterers with a memory of scattering parameters comprises selecting LF pulses having characteristics to change the scattering parameters of nonlinear scatterers. A transmit time relation is selected so that the incident HF pulse propagates sufficiently close to the LF pulse that the effect of the incident LF pulse on its scatterer parameters is observed by the HF pulse. At least two elastic wave pulse complexes comprising a high frequency (HF) pulse and a selected low frequency (LF) pulse are transmitted towards the region. Received HF signals are combined to form nonlinear HF signals representing the scatterers with memory, with suppression of received HF signals from other scatterers. At least one of the received HF signals may be corrected by time delay correction and/or speckle correction with a speckle correction filter, determined by movement of the scattering object. Systems are also disclosed.

Abstract: Measurement or imaging of elastic wave nonlinear scatterers with a memory of scattering parameters comprises selecting LF pulses having characteristics to change the scattering parameters of nonlinear scatterers. A transmit time relation is selected so that the incident HF pulse propagates sufficiently close to the LF pulse that the effect of the incident LF pulse on its scatterer parameters is observed by the HF pulse. At least two elastic wave pulse complexes comprising a high frequency (HF) pulse and a selected low frequency (LF) pulse are transmitted towards the region. Received HF signals are combined to form nonlinear HF signals representing the scatterers with memory, with suppression of received HF signals from other scatterers. At least one of the received HF signals may be corrected by time delay correction and/or speckle correction with a speckle correction filter, determined by movement of the scattering object. Systems are also disclosed.

Abstract: Elastic wave pulse complexes are transmitted towards said region where said pulse complexes are composed of a high frequency (HF) and a low frequency (LF) pulse with the same or overlapping beam directions and where the HF pulse is so close to the LF pulse that it observes the modification of the object by the LF pulse at least for a part of the image depth. Received HF signals are picked up by transducers from scattered and/or transmitted components of the transmitted HF pulses. The received HF signals are processed to form measurement or image signals for display, and combined in slow time to form noise suppressed HF signals or nonlinear scattering HF signals.

Abstract: An acoustic probe transmits/receives acoustic pulses with frequencies both in a high frequency (HF), and a selectable amount of lower frequency (LF1, LF2, . . . , LFn, . . . ) bands. The radiation surfaces of at least two of the multiple frequency bands have a common region. The arrays and elements can be of a general type such as annular arrays, phased or switched arrays, linear arrays with division in both azimuth and elevation direction, like a 1.5D, a 1.75D and a full 2D array, or curved arrays. The element division, array type, and array aperture sizes for the different bands can also be different.

Abstract: Ultrasound probes that transmits/receives ultrasound pulses with frequencies both in a low frequency (LF) and a high frequency (HF) band, where the radiation surfaces of said HF and LF bands at least have a common region. Several solutions for transmission (and reception) of LF and HF pulses through the same radiation surface are given. The arrays and elements can be of a general type, for example linear phased or switched arrays, or annular arrays or elements with division in both azimuth and elevation direction, like a 1.5D, a 1.75D and a full 2D array. The LF and HF element division and array apertures can also be different.

Abstract: Ultrasound probes that transmits/receives ultrasound pulses with frequencies both in a low frequency (LF) and a high frequency (HF) band, where the radiation surfaces of said HF and LF bands at least have a common region. Several solutions for transmission (and reception) of LF and HF pulses through the same radiation surface are given. The arrays and elements can be of a general type, for example linear phased or switched arrays, or annular arrays or elements with division in both azimuth and elevation direction, like a 1.5D, a 1.75D and a full 2D array. The LF and HF element division and array apertures can also be different.