Abstract: The present invention generally relates to microarrays and particularly to microarrays in which the optimal hybridization temperature and stringency of the probes may be easily determined by a designed set of nucleic acids. The present invention further discloses the use of a designed set of nucleic acids in a microarray to determine the optimal hybridization temperature of the nucleic acids forming said microarray and to a kit for the determination of the optimal hybridization temperature of a microarray.

Abstract: The present invention discloses an improved cDNA microarray, which employs spacers of random sequence and a length of the spacers of at least 50 to 80 nucleotides. The inventive cDNA microarray may be employed for example in fields like the determination of gene expression, DNA sequencing, fingerprinting or mapping. In addition, a method for the preparation of the cDNA microarray, the use of spacer molecules with random sequence and a kit are specified.

Abstract: The present invention pertains to modular array arrangements comprising a carrier and at least one insert for attachment to said carrier, which at least one insert may be positioned in or on said carrier in a predetermined, fixed orientation. In addition, the present invention relates to an insert having first connecting means and at least one section adapted for the application of samples, to a method of preparing a modular array arrangement and to a method for using such modular array arrangements in a screening assay.

Abstract: A biomolecules detection method, where the biomolecules to be detected are coupled to a first substance which is part of a nucleic acid replicating device, the formed biomolecule/substance complexes being bound to the solid phase bound binding molecule specific to the particular biomolecule, and, if called for, the non-bound biomolecule/substance complexes being removed by washing, the bound biomolecule/substance complexes being incubated with high molecular weight nucleic acid molecules and mononucleotides of different species, of which at least the mononucleotides of one species are fitted with detectable markings, further being incubated with a second substance complementing the first substance coupled to the biomolecules into a functional, replicating device for high molecular weight nucleic acids that binds the high molecular weight nucleic acids, and with integration of marked mononucleotides generating replicas of the high molecular weight nucleic acid molecules that do not dissociate off it, where cal

Abstract: The present invention relates to a new method for determining the RNAi mediated transcriptional regulation of a cell by the determination of a pattern of at least 3 miRNA detected simultaneously and quantified in the same cell extract.

Abstract: The present invention relates to a new method for determining the RNAi mediated transcriptional regulation of a cell by the determination of a pattern of at least 3 miRNA detected simultaneously and quantified in the same cell extract.

Abstract: The present invention pertains to modular array arrangements comprising a carrier and at least one insert for attachment to said carrier, which at least one insert may be positioned in or on said carrier in a predetermined, fixed orientation. In addition, the present invention relates to an insert having first connecting means and at least one section adapted for the application of samples, to a method of preparing a modular array arrangement and to a method for using such modular array arrangements in a screening assay.

Abstract: The present invention pertains to a chamber array arrangement comprising a container with at least two chambers, each of which contain a probe carrier in form of solid particles. The present invention also relates to a method for performing a screening assay using the chamber array arrangement.

Abstract: A pipetting device for detachably mountable pipette tips, comprising a moving device, a piston movable by the moving device in a cylinder to displace a column of air, an attachment stem for mounting a pipette tip, with an aperture having a connection to the cylinder at the free end, two stops limiting the movement of the piston during the displacement of the column of air, one of which is dislocatable, a precise adjustment device for dislocating the dislocatable stop in parallel with the piston for a precise adjustment of the piston stroke, a coupling device which puts the precise adjustment device into function, when coupled, and puts it out of function, when uncoupled, a rough adjustment device for dislocating the dislocatable stop when the precise adjustment device is uncoupled, for a rough adjustment of the piston stroke, and a measuring and indicating device coupled to the dislocatable stop for measuring the position set for the dislocatable stop and indicating the proportioning volume that matches the p

Abstract: The present invention relates to a novel method for determining the biological effect of a siRNA species in a cell. In particular, the present invention provides a method, wherein a support is provided, containing on predetermined locations thereof nucleic acids, representing or giving rise to a siRNA species. The support is covered by cells, into which the siRNA are taken up and exert their effect. Then the biological effect of the siRNA in the cell may be determined.

Abstract: A pipetting device for detachably mountable pipette tips, comprising a moving device, a piston movable by the moving device in a cylinder to displace a column of air, an attachment stem for mounting a pipette tip, with an aperture having a connection to the cylinder at the free end, two stops limiting the movement of the piston during the displacement of the column of air, one of which is dislocatable, a precise adjustment device for dislocating the dislocatable stop in parallel with the piston for a precise adjustment of the piston stroke, a coupling device which puts the precise adjustment device into function, when coupled, and puts it out of function, when uncoupled, a rough adjustment device for dislocating the dislocatable stop when the precise adjustment device is uncoupled, for a rough adjustment of the piston stroke, and a measuring and indicating device coupled to the dislocatable stop for measuring the position set for the dislocatable stop and indicating the proportioning volume that matches the p

Abstract: A method for analyzing biomolecules. The biomolecules are immobilized on a support and then incubated with probe molecules that are capable of binding to the biomolecules. The probe molecules are provided with different markings, which comprise particle-shaped supports. The bound probe molecules are separated from the support and are analyzed using a separate apparatus, which is able to differentiate between the different markings.