Patents by Inventor Sven Frie

Sven Frie has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210034028
    Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.
    Type: Application
    Filed: October 16, 2020
    Publication date: February 4, 2021
    Applicant: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
    Inventors: Steve Robert Gravallese, Jason Naylor, Edwin Brian Taylor, Sven Frie, Patrick McMahon
  • Patent number: 10831169
    Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: November 10, 2020
    Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLC
    Inventors: Steve Robert Gravallese, Jason Naylor, Edwin Brian Taylor, Sven Frie, Patrick McMahon
  • Publication number: 20190302720
    Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.
    Type: Application
    Filed: June 20, 2019
    Publication date: October 3, 2019
    Applicant: GE Healthcare Bio-Sciences Corp.
    Inventors: Steve Robert Gravallese, Jason Naylor, Edwin Brian Taylor, Sven Frie, Patrick McMahon
  • Patent number: 10372100
    Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system comprises a warehouse facility, a hydration facility, and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility and hydration facility are comprised in the macro structure. Each biopharmaceutical manufacturing facility is comprised in a respective micro node, and a control facility in the macro structure is configured to control interoperability of the macro structure and the micro nodes by means of a network spine interconnecting the macro structure with each micro node.
    Type: Grant
    Filed: August 29, 2016
    Date of Patent: August 6, 2019
    Assignee: GE Healthcare Bio-Sciences Corp.
    Inventors: Steve Robert Gravallese, Jason Naylor, Edwin Brian Taylor, Sven Frie, Patrick McMahon
  • Publication number: 20180059632
    Abstract: The present disclosure relates to a manufacturing system, method and control circuitry for quality assured manufacturing of at least two biopharmaceutical products. The manufacturing system (100) comprises a warehouse facility (210), a hydration facility (220), and at least two biopharmaceutical manufacturing facilities, wherein the warehouse facility (210) and hydration facility (220) are comprised in the macro structure (200). Each biopharmaceutical manufacturing facility is comprised in a respective micro node (300), and a control facility (230) in the macro structure (200) is configured to control interoperability of the macro structure (200) and the micro nodes (300) by means of a network spine interconnecting the macro structure (200) with each micro node (300).
    Type: Application
    Filed: August 29, 2016
    Publication date: March 1, 2018
    Inventors: Steve Robert Gravallese, Jason Naylor, Edwin Brian Taylor, Sven Frie, Patrick McMahon
  • Patent number: 8916518
    Abstract: The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the protein which reacts with the aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Grant
    Filed: May 28, 2009
    Date of Patent: December 23, 2014
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Jurgen Hemberger, Michele Orlando, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Patent number: 8466277
    Abstract: The invention relates to a method for coupling low-molecular weight substances to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the low-molecular weight substance is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the low-molecular weight substance which reacts with this aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: June 18, 2013
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Michele Orlando, Jurgen Hemberger, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Publication number: 20120259107
    Abstract: The invention relates to a method for coupling low-molecular substances to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the low-molecular substance is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the low-molecular substance which reacts with this aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of said conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Application
    Filed: June 12, 2012
    Publication date: October 11, 2012
    Inventors: Michele Orlando, Jurgen Hemberger, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Patent number: 7816516
    Abstract: The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.
    Type: Grant
    Filed: March 15, 2002
    Date of Patent: October 19, 2010
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Cornelius Jungheinrich, Roland Scharpf, Katharina Lutterbeck, Jurgen Hemberger, Michele Orlando
  • Publication number: 20090233847
    Abstract: The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the protein which reacts with the aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Application
    Filed: May 28, 2009
    Publication date: September 17, 2009
    Inventors: Jurgen Hemberger, Michele Orlando, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Patent number: 7541328
    Abstract: The invention relates to a method for coupling proteins to a starch-derived modified polysaccharide. The binding interaction between the modified polysaccharide and the protein is based on a covalent bond which is the result of a coupling reaction between the terminal aldehyde group or a functional group of the modified polysaccharide molecule resulting from the chemical reaction of this aldehyde group and a functional group of the protein which reacts with the aldehyde group or with the resulting functional group of the polysaccharide molecule. The bond directly resulting from the coupling reaction can be optionally modified by a further reaction to the aforementioned covalent bond. The invention further relates to pharmaceutical compositions that comprise conjugates formed in this coupling process and to the use of conjugates and compositions for the prophylaxis or therapy of the human or animal body.
    Type: Grant
    Filed: February 28, 2003
    Date of Patent: June 2, 2009
    Assignee: Fresenius Kabi Deutschland GmbH
    Inventors: Jurgen Hemberger, Michele Orlando, Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Katharina Lutterbeck, Cornelius Jungheinrich, Roland Scharpf
  • Publication number: 20060188472
    Abstract: The invention relates to compounds comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.
    Type: Application
    Filed: February 10, 2006
    Publication date: August 24, 2006
    Inventors: Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Cornelius Jungheinrich, Roland Scharpf, Katharina Lutterbeck
  • Publication number: 20050063943
    Abstract: The invention relates to compounds, comprising a conjugate of hydroxyalkyl starch (HAS) and an active agent, whereby the hydroxyalkyl starch is either directly covalently bonded to the active agent, or by means of a linker. The invention further relates to methods for the production of a covalent HAS-active agent conjugate, whereby HAS and an active agent are reacted in a reaction medium, characterised in that the reaction medium is water or a mixture of water and an organic solvent, comprising at least 10 wt. % water.
    Type: Application
    Filed: March 15, 2002
    Publication date: March 24, 2005
    Inventors: Klaus Sommermeyer, Wolfram Eichner, Sven Frie, Cornelius Jungheinrich, Roland Scharpf, Katharina Lutterbeck