Patents by Inventor Sven Hastrup
Sven Hastrup has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20010036910Abstract: A cellulase preparation consisting essentially of a homogeneous endoglucanase component which is immunoreactive with an antibody raised against a highly purified ˜43kD endoglucanase derived from Humicola insolens, DSM 1800, or which is homogenous to said 43kD endoglucanase, may be employed in the treatment cellulose-containing fabrics for harshness reduction or color clarification or to provide a localized variation in the color of such fabrics, or it may be employed in the treatment of paper pulp.Type: ApplicationFiled: December 13, 2000Publication date: November 1, 2001Inventors: Grethe Rasmussen, Jan Moller Mikkelsen, Martin Schulein, Shamkant Anant Patkar, Fred Hagen, Carsten Mailand Hjort, Sven Hastrup
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Patent number: 6197567Abstract: Enzymes produced by mutating the genes for a number of subtilisin proteases and expressing the mutated genes in suitable hosts are presented. The enzyme exhibit improved wash performance in comparison to their wild type parent enzymes. The enzymes are well-suited for use in detergent compositions.Type: GrantFiled: March 12, 1997Date of Patent: March 6, 2001Assignees: Novo Nordisk A/S, Unilever PLCInventors: Dorrit Aaslyng, Sven Branner, Sven Hastrup, Leif Nørskov-Lauritsen, Ole Hvilsted Olsen, Merete Simonsen, Eric Casteleijn, Maarten Robert Egmond, Johan Haverkamp, John David Marugg, Arnoldus Theodorus Anthonius Mooren
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Patent number: 6171823Abstract: The invention relates to a method of producing an extracellular protein in a bacterium provided with an inner and an outer cell membrane, the method comprising: (a) providing a recombinant vector including a DNA construct comprising a DNA sequence encoding the prepropeptide or part of the prepropeptide of a bacterial extracellular protease selected from the group consisting of Achromobacter lyticus protease I, Bacillus metalloproteases and Bacillus serine proteases preceding and operably connected to a DNA sequence encoding a desired protein, (b) transforming cells of a microorganism provided with an inner and outer cell membrane with the recombinant vector of step (a), (c) culturing the transformed cells of step (b) under conditions permitting expression of said DNA insert and leakage of the bacterial extracellular protease propeptide fused to the desired protein into the culture medium, and (d) recovering the resulting protein from the medium.Type: GrantFiled: June 2, 1997Date of Patent: January 9, 2001Assignee: Novo Nordisk A/SInventors: Helle Fabricius Wöldike, Sven Hastrup
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Patent number: 5948672Abstract: A cellulase preparation consisting essentially of a homogeneous endoglucanase component which is immunoreactive with an antibody raised against a highly purified .about.43 kD endoglucanase derived from Humicola insolens, DSM 1800, or which is homogeneous to said .about.43 kD endoglucanase, may be employed in the treatment cellulose-containing fabrics for harshness reduction or color clarification or to provide a localized variation in the color of such fabrics, or it may be employed in the treatment of paper pulp.Type: GrantFiled: February 14, 1995Date of Patent: September 7, 1999Assignee: Novo Nordisk A/SInventors: Grethe Rasmussen, Jan M.o slashed.ller Mikkelsen, Martin Schulein, Shamkant Anant Patkar, Fred Hagen, Carsten Mailand Hjort, Sven Hastrup
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Patent number: 5763254Abstract: The present invention relates to isolated and purified cellulose- or hemicellulose-degrading enzymes, comprising a catalytically active domain, a carbohydrate binding domain and a linking B region which operably links the catalytically active domain and the carbohydrate binding domain, wherein the carbohydrate binding domain has the following core sequence: ##STR1## wherein the enzyme is endogenous to a strain of a fungus other than Trichoderma or Phanerochaete.Type: GrantFiled: June 7, 1995Date of Patent: June 9, 1998Assignee: Novo Nordisk A/SInventors: Helle Fabricius Woldike, Fred Hagen, Carsten Mailand Hjort, Sven Hastrup
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Patent number: 5741694Abstract: The present invention relates to mutations of the subtilisin gene, some of which result in changes in the chemical characteristics of subtilisin enzyme. Mutations are created at specific nucleic acids of the subtilisin gene and, in various specific embodiments, the mutant enzymes possess altered chemical properties including, but not limited to, increased stability to oxidation, augmented proteolytic activity, and improved washability. The present invention also relates, but is not limited to, the amino acid and DNA sequences for two proteases derived from Bacillus lentus variants, subtilisin 147 and subtilisin 309, as well as mutations of these genes and the corresponding mutant enzymes.Type: GrantFiled: June 7, 1995Date of Patent: April 21, 1998Assignee: Novo Nordisk A/SInventors: Sven Hastrup, Sven Branner, Fanny Norris, Steffen Bj.o slashed.rn Petersen, Leif N.o slashed.rskov-Lauridsen, Villy Johannes Jensen, Dorrit Aaslyng
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Patent number: 5702934Abstract: The present invention is related to a process for producing an active enzyme comprising fermenting the proform of the active enzyme in the present of a proteolytic enzyme different from the active enzyme and capable of converting the proenzyme into an active enzyme as well as to host cells, recombinant expression vectors and host cells suitable for use in the process.Type: GrantFiled: May 4, 1994Date of Patent: December 30, 1997Assignees: Novo Nordisk A/S, Novo Nordisk Biotech, Inc.Inventors: Sven Hastrup, Sven Branner, Birthe Ravn J.o slashed.rgensen, Tove Christensen, Birgitte Bojer J.o slashed.rgensen, Jeffrey R. Shuster, Mark Madden, Donna L. Moyer, Claus Fuglsang
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Patent number: 5693520Abstract: An active recombinant trypsin-like protease enzyme comprising the amino acid residues 25-224 of the amino acid sequence of SEQ ID NO:2, as well as a DNA construct encoding the enzyme and comprising the sequence of SEQ ID NO:1. The enzyme may be used as a detergent enzyme.Type: GrantFiled: November 3, 1995Date of Patent: December 2, 1997Assignee: Novo Nordisk A/SInventors: Sven Branner, Sven Hastrup
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Patent number: 5686593Abstract: The present invention relates to cellulose- or hemicellulose-degrading enzymes which is derivable from a fungus other than Trichoderma or Phanerochaete, and which comprises a carbohydrate binding domain homologous to a terminal A region of Trichoderma reesei cellulases, which carbohydrate binding domain comprises the following amino acid sequence. ##STR1## or a subsequence thereof capable of effecting binding of the enzyme to an insoluble cellulosic or hemicellulosic substrate.Type: GrantFiled: June 7, 1995Date of Patent: November 11, 1997Assignee: Novo Nordisk A/SInventors: Helle Fabricius Woldike, Fred Hagen, Carsten Mailand Hjort, Sven Hastrup
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Patent number: 5665587Abstract: The present invention relates to modified subtilisins comprising a mutation in an amino acid sequence of a subtilisin at a position selected from the group consisting of 1, 2, 3, 4, 6, 9, 10, 12, 14, 15, 17, 18, 19, 20, 21, 22, 24, 25, 27, 36, 37, 38, 40, 41, 43, 44, 45, 46, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 75, 76, 77, 78, 79, 87, 89, 91, 94, 97, 98, 99, 100, 101, 103, 104, 105, 106, 107, 108, 109, 112, 113, 115, 116, 117, 118, 120, 126, 128, 129, 130, 131, 133, 134, 136, 137, 140, 141, 143, 144, 145, 146, 155, 156, 158, 159, 160, 161, 162, 163, 164, 165, 166, 167, 170, 171, 172, 173, 181, 182, 183, 184, 185, 186, 188, 189, 191, 192, 194, 195, 197, 204, 206, 209, 210, 211, 212, 213, 214, 215, 216, 217, 218, 235, 236, 237, 238, 239, 240, 241, 242, 243, 244, 245, 247, 248, 249, 251, 252, 253, 254, 255, 256, 257, 259, 260, 261, 262, 263, 265, 269, 271, 272 and 275. The present invention also relates to detergent compositions comprising a modified subtilisin of the present invention.Type: GrantFiled: June 7, 1995Date of Patent: September 9, 1997Assignees: Novo Nordisk A/S, Unilever PLCInventors: Dorrit Aaslyng, Sven Branner, Sven Hastrup, Leif N.o slashed.rskov-Lauritsen, Ole Hvilsted Olsen, Merete Simonsen, Eric Casteleijn, Maarten Robert Egmond, Johan Haverkamp, John David Marugg, Arnoldus Theodorus Anthonius Mooren
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Patent number: 5631217Abstract: This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production, and to their uses including for example enzymatic detergent and cleaning compositions containing them.Type: GrantFiled: September 13, 1995Date of Patent: May 20, 1997Assignees: Novo Nordisk A/S, Unilever PLCInventors: Sven Branner, Sven Hastrup, Nina Eriksen, Poul Lindegaard, Ole H. Olsen, Eric Casteleijn, Maarten R. Egmond, Johan Haverkamp, Wouter Musters, Jakob de Vlieg
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Patent number: 5482849Abstract: This invention relates to enzymes, to rDNA techniques applicable for example to their production, to mutated genes, vectors and mutant and transformed microorganisms useful in their production, and to their uses including for example enzymatic detergent and cleaning compositions containing them.Type: GrantFiled: December 20, 1991Date of Patent: January 9, 1996Assignee: Novo Nordisk A/SInventors: Sven Branner, Sven Hastrup, Nina Eriksen, Poul Lindegaard, Ole H. Olsen, Eric Casteleijn, Maarten R. Egmond, Johan Haverkamp, Wouter Musters, Jakob de Vlieg
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Patent number: 5457046Abstract: A cellulose- or hemicellulose-degrading enzyme which is derivable from a fungus other than Trichoderma or Phanerochaete, and which comprises a carbohydrate binding domain homologous to a terminal A region of Trichoderma reesei cellulases, which carbohydrate binding domain amino acid sequence (.alpha.) or a subsequence thereof capable of effecting binding of the enzyme to an insoluble cellulosic or hemicellulosic substrate.Type: GrantFiled: December 22, 1994Date of Patent: October 10, 1995Assignee: Novo Nordisk A/SInventors: Helle F. Woldike, Fred Hagen, Carsten Hjort, Sven Hastrup
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Patent number: 5036002Abstract: Gene expression systems comprising an expression vector and a "trans-acting DNA segment", where the expression vector comprises the gene or genes to be expressed and one or more cis-acting regulatory elements which are responsive to a trans-acting factor produced by said "trans-acting DNA segment". More specifically the invention relates to such gene expression systems where said "trans-acting DNA segment" and said cis-acting regulatory elements comprise one or more segments of the genome from a Bacillus species. Methods for stimulating the production of gene products, vectors for transforming microorganisms, and their use are also disclosed.Type: GrantFiled: April 17, 1987Date of Patent: July 30, 1991Assignee: Novo-Nordisk A/SInventor: Sven Hastrup