Abstract: The present application provides quinoline-3-carboxamide compounds covalently linked to a label for use in the diagnosis of an inflammatory disease at local site. The above mentioned compounds can be used to detect or image accumulation of S100A9 in the body of a subject at sites of inflammation, using in vivo non-invasive molecular imaging techniques for the detection of said compounds. Accordingly, labeled quinoline-3-carboxamide compounds can be applied to evaluate the risk of a subject of developing an inflammatory disease and to follow the progress of the disease.

Abstract: The present application provides quinoline-3-carboxamide compounds covalently linked to a label for use in the diagnosis of an inflammatory disease at local site. The above mentioned compounds can be used to detect or image accumulation of S100A9 in the body of a subject at sites of inflammation, using in vivo non-invasive molecular imaging techniques for the detection of said compounds. Accordingly, labeled quinoline-3-carboxamide compounds can be applied to evaluate the risk of a subject of developing an inflammatory disease and to follow the progress of the disease.

Abstract: A human-machine interface (HMI) application (26) uses parallel processing. The HMI engineering system (24) allows explicit specification (44) of different cores of a multi-core processor (16) for different elements and/or actions. The programmer may design the HMI application for concurrent operation. The HMI engineering system (24) or runtime system (28) may test (56) for data dependency amongst the elements or actions and automatically assigns different cores where data is independent. During runtime, different threads for the HMI application (e.g., different elements and/or actions) are scheduled for different cores.

Abstract: Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

Abstract: An arrangement is proposed for creating and executing human-machine interface (HMI) applications in various heterogeneous computing and communication environments. The arrangement includes an engineering system for designing HMI applications based upon a library of known HMI elements, a runtime system for determining an optimum configuration for executing the designed HMI applications and a knowledge repository that communicates with both the engineering system and the runtime system. The knowledge repository stores information related to various ones of the known HMI elements, as well as information created by application developers and information generated during execution of an HMI application by the runtime system. Thus, the knowledge repository can interact with the engineering system for updating information regarding selected elements and interacting with the runtime system to collect execution information for use in subsequent application developments.

Abstract: An arrangement is proposed for creating and executing human-machine interface (HMI) applications in various heterogeneous computing and communication environments. The arrangement includes an engineering system for designing HMI applications based upon a library of known HMI elements, a runtime system for determining an optimum configuration for executing the designed HMI applications and a knowledge repository that communicates with both the engineering system and the runtime system. The knowledge repository stores information related to various ones of the known HMI elements, as well as information created by application developers and information generated during execution of an HMI application by the runtime system.

Abstract: A human-machine interface (HMI) application (26) uses parallel processing. The HMI engineering system (24) allows explicit specification (44) of different cores of a multi-core processor (16) for different elements and/or actions. The programmer may design the HMI application for concurrent operation. The HMI engineering system (24) or runtime system (28) may test (56) for data dependency amongst the elements or actions and automatically assigns different cores where data is independent. During runtime, different threads for the HMI application (e.g., different elements and/or actions) are scheduled for different cores.

Abstract: Novel compounds and pharmaceutical compositions having MMP inhibitory activity are disclosed, which have been found to be particularly useful in the prevention, treatment and diagnostic imaging of diseases associated with an unpaired activity of MMP, amongst others MMP-2, MMP-8, MMP-9 and/or MMP-13 to name a few. The compounds of the present invention are useful for the prevention, the treatment and the in vivo diagnostic imaging of a range of disease states (inflammatory, malignant and degenerative diseases) where specific matrix metalloproteinases are known to be involved.

Abstract: The present invention relates to the field of therapeutic and diagnostic agents and more specifically to compounds of formula (I) that are inhibitors of matrix-metalloproteinases (MMPs) and are useful in the treatment of diseases related thereto such as cardiovascular diseases, inflammatory diseases and malignant diseases. One embodiment of the invention is a compound of formula (I) labeled with a 18-fluorine atom having matrix metalloproteinase inhibitory activity suitable for diagnostic imaging. Also disclosed in the present invention is a pharmaceutical composition comprising the inhibitors of matrix-metalloproteinases (MMPs) of the invention or the corresponding labeled compounds useful as diagnostic imaging agents of the invention in a form suitable for mammalian administration.

Abstract: Messages are delivered in a communications network by monitoring an arrival rate of messages destined for a geographical area within a short time period. Then, upon reaching a threshold, a multicast group is established for routing the messages to the geographical area. Network devices responsible for delivering the messages join the multicast group and the messages are delivered to the geographical area upon establishment of the multicast group.

Abstract: A method of measuring a lower similar layer that is separated from an upper similar layer by an intervening dissimilar layer in an integrated circuit. A first electron beam having a first relatively lower landing energy is directed at the integrated circuit. The first relatively lower landing energy is sufficient to completely penetrate the upper similar layer and insufficient to completely penetrate the intervening dissimilar layer, thereby producing first readings that are characteristic of the upper similar layer. A second electron beam having a second relatively higher landing energy is directed at the integrated circuit, the second relatively higher landing energy is sufficient to completely penetrate the upper similar layer, the intervening dissimilar layer, and the lower similar layer, thereby producing second readings that are characteristic of both the upper similar layer and the lower similar layer.