Abstract: The present invention relates to methods for estimation of efficacy of therapeutic treatment of cancer patients, in particular breast cancer patients. The estimation is based on determining of the status of aberration of the estrogen receptor alpha gene (ESR1) in situ, and, optionally, the status of aberration of a gene related to ESR1. In particular, the invention relates to determining the presence or absence and, if present, the type of aberration, e.g. amplification, duplication, polyploidization, deletion or translocation of the ESR1 gene in the tumor cells of the patient. The invention further relates to a kit-in-parts comprising probes for the determining the status of aberration of ESR1 and ESR1-related genes in situ.

Abstract: A device for suspending a rail, such as a travel rail of an overhead conveyor or a hoisting machine, from a traversing gear or supporting structure includes a tension element secured by one end to the rail. A bolt passes through the tension element and is received by a fixing device that is secured to the rail. The tension element is at least partly recessed in the fixing device in the direction of suspension. In order to provide a secure device that has a long service life and a low structural height, the tension element is fastened to the bolt by a ball-shaped joint, such as a pivoting bearing.

Abstract: A device for suspending a rail of an overhead conveyor or a hoisting machine from a traversing gear or supporting structure includes a tension element, which carries the rail by one end via a fixing device. The fixing device grasps a support element of the rail. The support element widens and extends at least partly in the lengthwise direction of the rail. To provide a device for suspending a rail that provides enhanced safety against collapse, the fixing device includes two fixing parts, which are connected like pliers by means of a bolt running in the lengthwise direction of the rail. The fixing parts swivel toward each other from the open position into the fixing position by their fixing regions. The support element of the rail rests against the bearing surfaces of the fixing parts, even in the open position, when the fastening means are released.

Abstract: An arrangement for axial securing of a grooved bolt includes a holding element and a securing element. The grooved bolt passes through the holding element in the axial direction. The securing element, which may be connected to the holding element, engages the groove of the bolt and secures the bolt in a locked position.

Abstract: A clamp for a cylindrical includes a base portion and a clamping portion which define together a common through opening for passage of a cylindrical element. Fasteners are provided to brace the base portion and the clamping portion to thereby hold the cylindrical element in a clamping zone. The base portion and the clamping portion are each provided with an attachment surface, wherein the attachment surface of the clamping portion includes a cutout formed with internal teeth for optional positive engagement of external circumferential teeth of a protrusion of a base portion of a further such base portion or external circumferential teeth of a protrusion of a connection piece, such that the internal and external teeth are constrained against rotation. Thus, a series of clamps can be stacked on top of one another.

Abstract: A clamp for a cylindrical includes a base portion and a clamping portion which define together a common through opening for passage of a cylindrical element. Fasteners are provided to brace the base portion and the clamping portion to thereby hold the cylindrical element in a clamping zone. The base portion and the clamping portion are each provided with an attachment surface, wherein the attachment surface of the claming portion includes a cutout formed with internal teeth for optional positive engagement of external circumferential teeth of a protrusion of a base portion of a further such base portion or external circumferential teeth of a protrusion of a connection piece, such that the internal and external teeth are constrained against rotation. Thus, a series of clamps can be stacked on top of one another.

Abstract: Novel yeast promoters for either EF1-alpha protein or ribosomal protein S7 gene suitable for expression cloning in yeast and heterologous expression of proteins in yeast. The yeast promoters are preferably active in the pH range 4-11 without peptone and obtained from the yeast strain Yarrowia lipolytica.