Patents by Inventor Sven Ruf

Sven Ruf has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
    Patent number: 7470706
    Abstract: The invention relates to cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: December 30, 2008
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventors: Elisabeth Defossa, Dieter Kadereit, Thomas Klabunde, Dieter Schmoll, Andreas Herling, Karl-Ulrich Wendt, Sven Ruf
  • 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
    Patent number: 7402674
    Abstract: 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments The invention relates to 7-phenylamino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
    Type: Grant
    Filed: January 25, 2005
    Date of Patent: July 22, 2008
    Assignee: Sanofi-Aventis Deutschland GmbH,
    Inventors: Elisabeth Defossa, Dieter Kadereit, Sven Ruf, Thomas Klabunde, Dieter Schmoll, Andreas Herling, Karl-Ulrich Wendt
  • Cyclic Urea Compounds, Preparation Thereof and Pharmaceutical Use Thereof as Kinase Inhibitors
    Publication number: 20080108654
    Abstract: The disclosure relates to a cyclic urea compound of formula I: as defined herein, to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use as an inhibitor on a protein kinase. Thus, the compound of formula I is useful for preventing or treating a physiological disorder capable of being modulated by inhibiting the activity of a protein kinase, such as a solid tumor.
    Type: Application
    Filed: January 10, 2008
    Publication date: May 8, 2008
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Marcel PATEK, Anil NAIR, Augustin HITTINGER, Conception NEMECEK, Daniel BOND, Greg HARLOW, Herve BOUCHARD, Jacques MAUGER, Jean-Luc MALLERON, Mark PALERMO, Fahad AL-OBEIDI, Thomas FAITG, Hartmut STROBEL, Sven RUF, Kurt RITTER, Youssef EL-AHMAD, Dominique LESUISSE
  • Cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
    Patent number: 7354933
    Abstract: The present invention relates to a cyclic urea compound of formula I: as defined herein. The invention is also directed to the process for its preparation, pharmaceutical composition comprising it and its pharmaceutical use, as an inhibitor on a protein kinase. Thus, it is useful for preventing or treating a physiological disorder capable of being modulated by inhibiting the activity of a protein kinase, such as a solid tumor.
    Type: Grant
    Filed: February 2, 2004
    Date of Patent: April 8, 2008
    Assignee: Aventis Pharma SA
    Inventors: Marcel Patek, Anil Nair, Augustin Hittinger, Conception Nemecek, Daniel Bond, Greg Harlow, Herve Bouchard, Jacques Mauger, Jean-Luc Malleron, Mark Palermo, Fahad Al-Obeidi, Thomas Faitg, Hartmut Strobel, Sven Ruf, Kurt Ritter, Youssef El-Ahmad, Dominique Lesuisse, Didier Bénard
  • Substituted Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors
    Publication number: 20080021029
    Abstract: The disclosure relates to the novel compounds of formula (I): wherein R1, R2, R2?, R3, R3?, p, A, B, Y, Y1, and Y2 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
    Type: Application
    Filed: January 26, 2007
    Publication date: January 24, 2008
    Applicant: Aventis Pharma S.A.
    Inventors: Hartmut Strobel, Sven Ruf, Dominique Lesuisse, Conception Nemecek, Youssef El-Ahmad, Jacques Mauger, Stefan Guessregen, Kurt Ritter, Jean-Luc Malleron
  • Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors
    Publication number: 20080004300
    Abstract: The invention relates to compounds of formula (I): in which R1, R2, L1, X, R3, A, R4, R4?, R4?, R4??, R5, Y and L2 are as herein defined, salts and prodrugs thereof, to their use as protein kinase inhibitors, and to methods of treating diseases comprising adminstration thereof.
    Type: Application
    Filed: January 26, 2007
    Publication date: January 3, 2008
    Applicant: Aventis Pharma S.A.
    Inventors: Hartmut Strobel, Sven Ruf, Dominique Lesuisse, Conception Nemecek, Youssef El-Ahmad, Stefan Guessregen, Anne Lebrun, Kurt Ritter, Didier Benard, Augustin Hittinger, Herve Bouchard
  • Heterocycle-Substituted Cyclic Urea Derivatives, Preparation Thereof And Pharmaceutical Use Thereof As Kinase Inhibitors
    Publication number: 20070259891
    Abstract: The disclosure relates to compounds of formula (I): wherein Y, Y1, Yo, R1, R2, R2?, p, R3, R3?, A, B and Y2 have the meanings given in the description, and to salts thereof, pharmaceutical compositions comprising said compounds and use thereof as protein kinase inhibitors.
    Type: Application
    Filed: January 26, 2007
    Publication date: November 8, 2007
    Applicant: Aventis Pharma S.A.
    Inventors: Hartmut Strobel, Sven Ruf, Dominique Lesuisse, Conception Nemecek, Stefan Guessregen, Anne Lebrun, Kurt Ritter, Jean-Luc Malleron
  • Imino acid derivatives as inhibitors of matrix metalloproteinases
    Publication number: 20060252752
    Abstract: The invention relates to a bicycloazaheterocyclyl carboxylic acid sulfonamide derivative of formula I herein, pharmaceutical preparation comprising it, process for preparing it and method for its pharmaceutical use.
    Type: Application
    Filed: April 18, 2006
    Publication date: November 9, 2006
    Applicant: SANOFI-AVENTIS DEUTSCHLAND GMBH
    Inventors: Manfred Schudok, Sven Ruf, Hans Matter, Volkmar Wehner, Reinhard Kirsch, Petra Lennig
  • 7-phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
    Publication number: 20050182085
    Abstract: 7-Phenylamino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments The invention relates to 7-phenylamino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
    Type: Application
    Filed: January 25, 2005
    Publication date: August 18, 2005
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Elisabeth Defossa, Dieter Kadereit, Sven Ruf, Thomas Klabunde, Dieter Schmoll, Andreas Herling, Karl-Ulrich Wendt
  • Heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
    Publication number: 20050182086
    Abstract: The invention relates to heterocyclically substituted 7-amino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
    Type: Application
    Filed: January 25, 2005
    Publication date: August 18, 2005
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Elisabeth Defossa, Dieter Kadereit, Sven Ruf, Thomas Klabunde, Dieter Schmoll, Andreas Herling, Karl-Ulrich Wendt
  • Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments
    Publication number: 20050182087
    Abstract: Cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives, process for their preparation and their use as medicaments The invention relates to cycloalkyl-substituted 7-amino-4-quinolone-3-carboxylic acid derivatives and to the physiologically tolerated salts and physiologically functional derivatives thereof. The invention relates to compounds of the formula I in which the radicals have the stated meanings, and to the physiologically tolerated salts thereof. The compounds are suitable for example as medicaments for the prevention and treatment of type 2 diabetes.
    Type: Application
    Filed: January 25, 2005
    Publication date: August 18, 2005
    Applicant: Aventis Pharma Deutschland GmbH
    Inventors: Elisabeth Defossa, Dieter Kadereit, Thomas Klabunde, Dieter Schmoll, Andreas Herling, Karl-Ulrich Wendt, Sven Ruf
  • Imino acid derivatives as inhibitors of matrix metalloproteinases
    Publication number: 20050004166
    Abstract: The invention relates to a bicycloazaheterocyclyl carboxylic acid sulfonamide derivative of formula I herein, pharmaceutical preparation comprising it, process for preparing it and method for its pharmaceutical use.
    Type: Application
    Filed: January 5, 2004
    Publication date: January 6, 2005
    Applicant: AVENTIS PHARMA DEUTSCHLAND GMBH
    Inventors: Manfred Schudok, Sven Ruf, Hans Matter, Volkmar Wehner, Reinhard Kirsch, Petra Stahl
  • Novel cyclic urea derivatives, preparation thereof and pharmaceutical use thereof as kinase inhibitors
    Publication number: 20040248884
    Abstract: The present invention relates to a cyclic urea compound of formula I: 1
    Type: Application
    Filed: February 2, 2004
    Publication date: December 9, 2004
    Applicant: AVENTIS PHARMA S.A.
    Inventors: Marcel Patek, Anil Nair, Augustin Hittinger, Conception Nemecek, Daniel Bond, Greg Harlow, Herve Bouchard, Jacques Mauger, Jean-Luc Malleron, Mark Palermo, Fahad Al-Obeidi, Thomas Faitg, Hartmut Strobel, Sven Ruf, Kurt Ritter, Youssef El-Ahmad, Dominique Lesuisse
  • Cyclic N-substituted alpha-imino carboxylic acids for selective inhibition of collogenase
    Patent number: 6716853
    Abstract: The invention is related to compounds of formula I to pharmaceutical compositions comprising such compounds, to processes for the preparation of such compounds, and to methods of prevention and treatment of disorders, the progression of which involve an enhanced activity of matrix metalloproteinase 13, by administering to a patient in need thereof, a pharmaceutically effective amount of such compounds.
    Type: Grant
    Filed: February 26, 2003
    Date of Patent: April 6, 2004
    Assignee: Aventis Pharma Deutschland GmbH
    Inventors: Petra Stahl, Reinhard Kirsch, Sven Ruf, Volkmar Wehner, Klaus-Ulrich Weithmann
  • Cyclic N-substituted alpha-imino carboxylic acids for selective inhibition of collogenase
    Publication number: 20030199543
    Abstract: The invention is related to compounds of formula I 1
    Type: Application
    Filed: February 26, 2003
    Publication date: October 23, 2003
    Applicant: Aventis Pharma Deutschland GmBH
    Inventors: Petra Stahl, Reinhard Kirsch, Sven Ruf, Volkmar Wehner, Klaus-Ulrich Weithmann