Patents by Inventor Svend Ludvigsen

Svend Ludvigsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Insulin derivatives containing additional disulfide bonds
    Patent number: 9512195
    Abstract: The present invention is related to insulin derivatives containing additional disulfide bonds and methods of making such.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: December 6, 2016
    Assignee: Novo Nordisk A/S
    Inventors: Peter Madsen, Frantisek Hubalek, Thomas Boerglum Kjeldsen, Svend Ludvigsen
  • Protease-stabilized insulin analogues
    Patent number: 9260502
    Abstract: The present invention relates to novel insulin analogs comprising mutations at position A14 in the A chain and at positions B27, B28, B29 and B30 in the B chain and exhibiting resistance towards protease; a method for the preparation of such insulin analogs; insulin preparations containing the insulin analogs of the invention; and, a method of treating diabetes mellitus using these insulin analogs.
    Type: Grant
    Filed: March 13, 2009
    Date of Patent: February 16, 2016
    Assignee: Novo Nordisk A/S
    Inventors: Peter Kresten Nielsen, Frantisek Hubalek, Inger Lautrup-Larsen, Per Balschmidt, Svend Ludvigsen, Thomas Børglum Kjeldsen
  • Preparation Comprising Insulin, Nicotinamide and an Amino Acid
    Publication number: 20150182595
    Abstract: Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
    Type: Application
    Filed: March 16, 2015
    Publication date: July 2, 2015
    Inventors: Helle Birk Olsen, Svend Havelund, Ulla Ribel-Madsen, Jeppe Sturis, Helle Naver, Morten Schlein, Svend Ludvigsen
  • Protease resistant insulin analogues
    Patent number: 9018161
    Abstract: The present invention relates to novel insulin analogues exhibiting resistance towards protease, wherein at least two amino acids are substituted and/or deleted relative to the parent insulin molecule. A method for the preparation of such insulin analogues, insulin preparations containing the insulin analogues of the invention and a method of treating diabetes mellitus using these insulin analogues is also provided.
    Type: Grant
    Filed: September 20, 2007
    Date of Patent: April 28, 2015
    Assignee: Novo Nordisk A/S
    Inventors: Peter Kresten Nielsen, Frantisek Hubalek, Inger Lautrup-Larsen, Svend Ludvigsen, Ulla Ribel-Madsen, Per Balschmidt, Per Nørgaard, Svend Havelund
  • Insulin derivatives Containing Additional Disulfide bonds
    Publication number: 20140371140
    Abstract: The present invention is related to insulin derivatives containing additional disulfide bonds and methods of making such.
    Type: Application
    Filed: August 28, 2014
    Publication date: December 18, 2014
    Inventors: Peter Madsen, Frantisek Hubalek, Thomas Boerglum Kjeldsen, Svend Ludvigsen
  • Human insulin containing additional disulfide bonds
    Patent number: 8883722
    Abstract: The present invention is related to human insulin containing additional disulfide bonds and methods of making such.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: November 11, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Frantisek Hubalek, Tine Nygaard Vinther, Thomas Boerglum Kjeldsen, Svend Ludvigsen
  • Insulin derivatives containing additional disulfide bonds
    Patent number: 8853155
    Abstract: The present invention is related to insulin derivatives containing additional disulfide bonds and methods of making such.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: October 7, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Peter Madsen, Frantisek Hubalek, Thomas Boerglum Kjeldsen, Svend Ludvigsen
  • Insulin analogues containing additional disulfide bonds
    Patent number: 8815798
    Abstract: The present invention is related to insulin analogs containing additional disulfide bonds and methods of making such.
    Type: Grant
    Filed: June 21, 2011
    Date of Patent: August 26, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Svend Ludvigsen, Frantisek Hubalek, Thomas B. Kjeldsen, Tine N. Vinther
  • Preparation Comprising Insulin, Nicotinamide and an Amino Acid
    Publication number: 20140206610
    Abstract: Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
    Type: Application
    Filed: March 24, 2014
    Publication date: July 24, 2014
    Applicant: Novo Nordisk A/S
    Inventors: Helle Birk Olsen, Svend Havelund, Ulla Ribel-Madsen, Jeppe Sturis, Helle Naver, Morten Schlein, Svend Ludvigsen
  • Stable formulations of peptides
    Patent number: 8748376
    Abstract: Stable pharmaceutical composition comprising insulinotropic peptide.
    Type: Grant
    Filed: December 21, 2009
    Date of Patent: June 10, 2014
    Assignee: Novo Nordisk A/S
    Inventors: Svend Ludvigsen, Morten Schlein, Tine Elisabeth Gottschalk Bøving, Claude Bonde, Anne-Mette Lilleøre, Dorthe Kot Engelund, Bjarne Rønfeldt Nielsen
  • Human Insulin Containing Additional Disulfide Bonds
    Publication number: 20130178414
    Abstract: The present invention is related to human insulin containing additional disulfide bonds and methods of making such.
    Type: Application
    Filed: June 21, 2011
    Publication date: July 11, 2013
    Applicant: NOVO NORDISK A/S
    Inventors: Frantisek Hubalek, Tine Nygaard Vinther, Thomas Boerglum Kjeldsen, Svend Ludvigsen
  • Insulin Analogues Containing Additional Disulfide Bonds
    Publication number: 20130172247
    Abstract: The present invention is related to insulin analogues containing additional disulfide bonds and methods of making such.
    Type: Application
    Filed: June 21, 2011
    Publication date: July 4, 2013
    Applicant: NOVO NORDISK A/S
    Inventors: Svend Ludvigsen, Frantisek Hubalek, Thomas Boerglum Kjeldsen
  • Insulin Derivatives Containing Additional Disulfide Bonds
    Publication number: 20130157938
    Abstract: The present invention is related to insulin derivatives containing additional disulfide bonds and methods of making such.
    Type: Application
    Filed: June 21, 2011
    Publication date: June 20, 2013
    Applicant: NOVO NORDISK A/S
    Inventors: Peter Madsen, Frantisek Hubalek, Thomas Boerglum Kjeldsen, Svend Ludvigsen
  • Preparation comprising insulin, nicotinamide and an amino acid
    Patent number: 8324157
    Abstract: Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
    Type: Grant
    Filed: December 1, 2011
    Date of Patent: December 4, 2012
    Assignee: Novo Nordisk A/S
    Inventors: Helle Birk Olsen, Svend Havelund, Ulla Ribel-Madsen, Jeppe Sturis, Helle Naver, Morten Schlein, Svend Ludvigsen
  • Preparation Comprising Insulin, Nicotinamide and an Amino Acid
    Publication number: 20120135920
    Abstract: Insulin preparations comprising an insulin compound or a mixture of two or more insulin compounds, a nicotinic compound and an amino acid.
    Type: Application
    Filed: December 1, 2011
    Publication date: May 31, 2012
    Applicant: Novo Nordisk A/S
    Inventors: Helle Birk Olsen, Svend Havelund, Ulla Ribel-Madsen, Jeppe Sturis, Helle Naver, Morten Schlein, Svend Ludvigsen
  • Soluble pharmaceutical compositions for parenteral administration comprising a GLP-1 peptide and an insulin peptide of short time action for treatment of diabetes and bulimia
    Patent number: 8158583
    Abstract: Pharmaceutical composition for parenteral administration comprising a meal related insulin peptide and an insulinotropic peptide.
    Type: Grant
    Filed: May 12, 2009
    Date of Patent: April 17, 2012
    Assignee: Novo Nordisk A/S
    Inventors: Liselotte Bjerre Knudsen, Kristian Tage Hansen, Dorthe Kot Engelund, Svend Ludvigsen, Lars Hansen, Claude Bonde, Ejvind Jensen, Tine Elisabeth Gottschalk Bøving, Morten Schlein
  • Method for making insulin precursors and insulin precursor analogues having improved fermentation yield in yeast
    Patent number: 8129146
    Abstract: Novel insulin precursors and insulin precursor analogs comprising a connecting peptide (mini C-peptide) of preferably up to 15 amino acid residues and comprising at least one Gly are provided. The precursors can be converted into human insulin or a human insulin analog. The precursors will typically have a distance between B27 (atom CG2) and A1 (atom CA) of less than 5 ?.
    Type: Grant
    Filed: April 17, 2008
    Date of Patent: March 6, 2012
    Assignee: Novo Nordisk A/S
    Inventors: Thomas Borglum Kjeldsen, Svend Ludvigsen
  • PROTEASE-STABILIZED INSULIN ANALOGUES
    Publication number: 20110092419
    Abstract: The present invention relates to novel insulin analogues comprising mutations at position A14 in the A chain and at positions B27, B28, B29 and B30 in the B chain and exhibiting resistance towards protease; a method for the preparation of such insulin analogues; insulin preparations containing the insulin analogues of the invention; and, a method of treating diabetes mellitus using these insulin analogues.
    Type: Application
    Filed: March 19, 2009
    Publication date: April 21, 2011
    Applicant: Novo Nordisk A/S
    Inventors: Peter Kresten Nielsen, Frantisek Hubalek, Inger Lautrup-Larsen, Per Balschmidt, Svend Ludvigsen, Thomas Børglum Kjeldsen
  • Ligands for the HisB10 Znsites of the R-state insulin hexamer
    Patent number: 7879893
    Abstract: The present invention relates to novel ligands for the HisB10 Zn2+ sites of the R-state insulin hexamer having the formula A-B-C-D-X (III), wherein: A is a chemical group which reversibly binds to a HisB10 Zn2+ sites of an insulin hexamer; B is a linker; C is a fragment consisting of 0 to 5 neutral amino acids; D is a fragment comprising 1 to 20 positively charged groups independently selected from amino or guanidino groups; and X is —OH, —NH2 or a diamino group. The present invention also relates to R-state insulin hexamers comprising such ligands, and aqueous insulin preparations comprising such R-state insulin hexamers.
    Type: Grant
    Filed: September 13, 2002
    Date of Patent: February 1, 2011
    Assignee: Novo Nordisk A/S
    Inventors: Helle Birk Olsen, Niels C. Kaarsholm, Peter Madsen, Soren Ostergaard, Svend Ludvigsen, Palle Jakobsen, Anders Klarskov Petersen, Dorte Bjerre Steensgaard
  • Stable Formulations of Peptides
    Publication number: 20100190715
    Abstract: Method for increasing the shelf-life of a pharmaceutical formulation comprising a glucagon-like peptide.
    Type: Application
    Filed: April 1, 2010
    Publication date: July 29, 2010
    Applicant: Novo Nordisk A/S
    Inventors: Morten Schlein, Svend Ludvigsen