Patents by Inventor Svetlana Lyapina

Svetlana Lyapina has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Regulation of target protein activity through modifier proteins
    Patent number: 6846663
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Grant
    Filed: January 14, 2002
    Date of Patent: January 25, 2005
    Assignee: California Institute of Technology
    Inventors: Svetlana A. Lyapina, Rati Verma, Raymond Deshaies, Greg Cope
  • Regulation of target protein activity through modifier proteins
    Publication number: 20040259193
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Application
    Filed: November 25, 2003
    Publication date: December 23, 2004
    Applicant: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Svetlana A. Lyapina, Rati Verma, Raymond Deshaies, Greg Cope
  • Regulation of target protein activity through modifier proteins
    Publication number: 20020156012
    Abstract: The present invention is based on the discovery that a polypeptide containing the JAB subunit or the JAM domain has peptidase activity, e.g., isopeptidase activity. The present invention provides polypeptides and crystalline polypeptides containing the JAM domain and methods of using such polypeptides to screen for agents capable of affecting the peptidase activity of the polypeptides. The present invention also provides methods of using the JAM domain for rational drug design or identifying agents capable of affecting the peptidase activity of the JAM domain.
    Type: Application
    Filed: January 14, 2002
    Publication date: October 24, 2002
    Inventors: Svetlana A. Lyapina, Rati Verma, Raymond Deshaies, Greg Cope
  • Assay for the ubiquitination-promoting activity of human proteins
    Patent number: 6165731
    Abstract: A method is provided for identifying an compound that affects an activity of a polypeptide subunit of a SCF complex. The method includes contacting a sample comprising a chimeric SCF complex assembled from subunits derived from Saccharomyces cerevisiae or human and another species and a CDC34p polypeptide with the compound under conditions that allow the components to interact, and adding to these components an E1 enzyme, ubiquitin and ATP, and a SCF substrate. The ubiquitination of the SCF substrate is measured. A chimeric in vitro assay system is provided for measuring CDC53p or CUL1p activity, comprising a CDC4p, CDC34p, and a SKP1p polypeptide, and either a CDC53p or CUL1p polypeptide. In this assay the CDC4p, CDC34p, and SKP1p polypeptide are either a yeast polypeptide or a polypeptide from another species, and at least one of the CDC4p, CDC34p, and SKP1p polypeptides is a yeast polypeptide and at least one of the CDC4p, CDC34p, and SKP1p polypeptides is a polypeptide from another species.
    Type: Grant
    Filed: January 22, 1999
    Date of Patent: December 26, 2000
    Assignee: California Institute of Technology
    Inventors: Raymond Deshaies, Svetlana Lyapina, Craig C. Correll