Patents by Inventor Svitlana Y. Berezhna
Svitlana Y. Berezhna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11226280Abstract: The present disclosure provides methods for automated slide assessments made in conjunction with digital image-based microscopy. Automated methods of acquiring patient information and specimen information from prepared slides, and digitally linking such information into patient-tagged specimen data, are provided. Also provided are methods that include automatically identifying an optimal area for morphological assessment of a blood smear on a hematological slide, including methods for triggering the analysis of such an area, e.g., using an automated digital image-based hematology system. The present disclosure also provides devices, systems and computer readable media for use in performing processes of the herein described methods.Type: GrantFiled: May 23, 2019Date of Patent: January 18, 2022Assignee: Abbott LaboratoriesInventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Kam Lin Wong, Damian John Verdnik, Leigh Whiting, Mahmoud Janbakhsh
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Patent number: 11215557Abstract: Provided are methods of assessing the cleanliness of a flow cell of a flow cytometric system. The provided methods include computing a ratio of post-flow cell and pre-flow cell light beam intensities and using such a ratio to assess the cleanliness of the flow cell. Flow cytometric systems capable of monitoring the cleanliness of a flow cell contained within the system are also provided.Type: GrantFiled: November 16, 2020Date of Patent: January 4, 2022Assignee: Abbott LaboratoriesInventors: Svitlana Y. Berezhna, JrHung T. Tsai, David Spalding, Mahesh R. Junnarkar, Chia-Fa Hsu
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Patent number: 11158049Abstract: The present disclosure includes methods of assessing a histologically stained specimen based on a determined color signature of a region of interest of the specimen. Such assessments may be performed for a variety of purposes including but not limited to assessing the quality of the histological stain, as part of identifying one or more biologically relevant features of the image, as part of differentiating one feature of the image from other features of the image, identifying an anomalous area of the stained specimen, classifying cells of the specimen, etc. Also provided are systems configured for performing the disclosed methods and computer readable medium storing instructions for performing steps of the disclosed methods.Type: GrantFiled: July 15, 2019Date of Patent: October 26, 2021Assignee: Abbott LaboratoriesInventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Marilou L. Coleman, Walter G. Stonas, Willie J. Cowart, Wenjing Li, Ema C. Olah
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Patent number: 11105736Abstract: The instant disclosure provides spectrophotometric methods for assessing histological stains used in a histology analyzer. The methods find use in various assessments including determinations of the identity of a histological stain, determinations of the quality of a histological stain, etc. Also included are devices and systems for practicing the described methods. The instant disclosure also provides computer readable media containing libraries of reference spectrophotometric characteristics of histological stains useful in assessing a histological stain used in a histology analyzer. Also provided is computer readable media containing instructions that cause a computing device to perform steps for making an assessment of a histological stain.Type: GrantFiled: March 18, 2019Date of Patent: August 31, 2021Assignee: Abbott LaboratoriesInventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Ema C. Olah
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Publication number: 20210131962Abstract: Provided are methods of assessing the cleanliness of a flow cell of a flow cytometric system. The provided methods include computing a ratio of post-flow cell and pre-flow cell light beam intensities and using such a ratio to assess the cleanliness of the flow cell. Flow cytometric systems capable of monitoring the cleanliness of a flow cell contained within the system are also provided.Type: ApplicationFiled: November 16, 2020Publication date: May 6, 2021Inventors: Svitlana Y. Berezhna, JrHung T. Tsai, David Spalding, Mahesh R. Junnarkar, Chia-Fa Hsu
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Publication number: 20210123839Abstract: The present disclosure provides methods for the automated control of aspects of slide preparation in an automated slide preparation instrument. Aspects of the methods include automated assessments of reagent amounts, quality and performance as well as automated adjustments of reagents based on such assessments, including the adjustment of reagent amounts, e.g., as present in reagent baths, the adjustment of reagent compositions and the replacement of reagents. Devices and systems useful in performing the described methods are also provided herein.Type: ApplicationFiled: November 11, 2020Publication date: April 29, 2021Inventors: Svitlana Y. Berezhna, Mahmoud Janbakhsh, Ema C. Olah, Robert Langsner
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Patent number: 10983305Abstract: Methods, systems and devices for automatically focusing a microscope on a specimen and collecting a focused image of the specimen are provided. Aspects of the methods include detecting the presence of a substrate in a microscope, determining whether the substrate is in a correct orientation for imaging, focusing the microscope on a specimen that is placed on the substrate, and collecting one or more images of the specimen. Systems and devices for carrying out the subject methods are also provided.Type: GrantFiled: July 16, 2019Date of Patent: April 20, 2021Assignee: Abbott LaboratoriesInventors: Trevor David Shields, Robert John Fahey, Damian J. Verdnik, Svitlana Y. Berezhna, Mahmoud Janbakhsh, Koshy T. Chacko
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Patent number: 10871426Abstract: The present disclosure provides methods for the automated control of aspects of slide preparation in an automated slide preparation instrument. Aspects of the methods include automated assessments of reagent amounts, quality and performance as well as automated adjustments of reagents based on such assessments, including the adjustment of reagent amounts, e.g., as present in reagent baths, the adjustment of reagent compositions and the replacement of reagents. Devices and systems useful in performing the described methods are also provided herein.Type: GrantFiled: October 24, 2017Date of Patent: December 22, 2020Assignee: Abbott LaboratoriesInventors: Svitlana Y. Berezhna, Mahmoud Janbakhsh, Ema C. Olah, Robert Langsner
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Patent number: 10866187Abstract: Provided are methods of assessing the cleanliness of a flow cell of a flow cytometric system. The provided methods include computing a ratio of post-flow cell and pre-flow cell light beam intensities and using such a ratio to assess the cleanliness of the flow cell. Flow cytometric systems capable of monitoring the cleanliness of a flow cell contained within the system are also provided.Type: GrantFiled: April 14, 2020Date of Patent: December 15, 2020Assignee: Abbott LaboratoriesInventors: Svitlana Y. Berezhna, JrHung T Tsai, David Spalding, Mahesh R. Junnarkar, Chia-Fa Hsu
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Publication number: 20200309693Abstract: Provided are methods of assessing the cleanliness of a flow cell of a flow cytometric system. The provided methods include computing a ratio of post-flow cell and pre-flow cell light beam intensities and using such a ratio to assess the cleanliness of the flow cell. Flow cytometric systems capable of monitoring the cleanliness of a flow cell contained within the system are also provided.Type: ApplicationFiled: April 14, 2020Publication date: October 1, 2020Inventors: Svitlana Y. Berezhna, JrHung T Tsai, David Spalding, Mahesh R. Junnarkar, Chia-Fa Hsu
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Publication number: 20200309802Abstract: Aspects of the present disclosure include systems and methods. According to certain embodiments, provided is an integrated analysis system that includes a first module including a sample analysis component and a first internal container conveyor system. The integrated analysis system further includes a second module including a second internal container conveyor system. The first and second modules are positioned adjacent each other such that the first and second internal container conveyor systems are aligned and adapted to transport containers from the first module to the second module. Also provided are methods of analyzing and preparing samples (e.g., blood and body fluid samples), as well as components that find use within the analysis systems of the present disclosure.Type: ApplicationFiled: April 15, 2020Publication date: October 1, 2020Inventors: Roger W. Accurso, Jiong Wu, Richard G. Kendall, James A. Janik, Ronald J. Shanafelter, Robert Fahey, Svitlana Y. Berezhna, Trevor David Shields, Mahmoud Janbakhsh, Daryl Wong, Jorge Haro, Michael J. Kennedy
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Patent number: 10648909Abstract: Provided are methods of assessing the cleanliness of a flow cell of a flow cytometric system. The provided methods include computing a ratio of post-flow cell and pre-flow cell light beam intensities and using such a ratio to assess the cleanliness of the flow cell. Flow cytometric systems capable of monitoring the cleanliness of a flow cell contained within the system are also provided.Type: GrantFiled: May 23, 2018Date of Patent: May 12, 2020Assignee: Abbott LaboratoriesInventors: Svitlana Y. Berezhna, JrHung T. Tsai, David Spalding, Mahesh R. Junnarkar, Chia-Fa Hsu
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Patent number: 10648995Abstract: Aspects of the present disclosure include systems and methods. According to certain embodiments, provided is an integrated analysis system that includes a first module including a sample analysis component and a first internal container conveyor system. The integrated analysis system further includes a second module including a second internal container conveyor system. The first and second modules are positioned adjacent each other such that the first and second internal container conveyor systems are aligned and adapted to transport containers from the first module to the second module. Also provided are methods of analyzing and preparing samples (e.g., blood and body fluid samples), as well as components that find use within the analysis systems of the present disclosure.Type: GrantFiled: December 14, 2016Date of Patent: May 12, 2020Assignee: Abbott LaboratoriesInventors: Roger W. Accurso, Jiong Wu, Richard G. Kendall, James A. Janik, Ronald J. Shanafelter, Robert Fahey, Svitlana Y. Berezhna, Trevor D. Shields, Mahmoud Janbakhsh, Daryl Wong, Jorge Haro, Michael J. Kennedy
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Publication number: 20200080934Abstract: The instant disclosure provides spectrophotometric methods for assessing histological stains used in a histology analyzer. The methods find use in various assessments including determinations of the identity of a histological stain, determinations of the quality of a histological stain, etc. Also included are devices and systems for practicing the described methods. The instant disclosure also provides computer readable media containing libraries of reference spectrophotometric characteristics of histological stains useful in assessing a histological stain used in a histology analyzer. Also provided is computer readable media containing instructions that cause a computing device to perform steps for making an assessment of a histological stain.Type: ApplicationFiled: March 18, 2019Publication date: March 12, 2020Inventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Ema C. Olah
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Publication number: 20200003990Abstract: Methods, systems and devices for automatically focusing a microscope on a specimen and collecting a focused image of the specimen are provided. Aspects of the methods include detecting the presence of a substrate in a microscope, determining whether the substrate is in a correct orientation for imaging, focusing the microscope on a specimen that is placed on the substrate, and collecting one or more images of the specimen. Systems and devices for carrying out the subject methods are also provided.Type: ApplicationFiled: July 16, 2019Publication date: January 2, 2020Inventors: Trevor David Shields, Robert John Fahey, Damian J. Verdnik, Svitlana Y. Berezhna, Mahmoud Janbakhsh, Koshy T. Chacko
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Publication number: 20200005459Abstract: The present disclosure includes methods of assessing a histologically stained specimen based on a determined color signature of a region of interest of the specimen. Such assessments may be performed for a variety of purposes including but not limited to assessing the quality of the histological stain, as part of identifying one or more biologically relevant features of the image, as part of differentiating one feature of the image from other features of the image, identifying an anomalous area of the stained specimen, classifying cells of the specimen, etc. Also provided are systems configured for performing the disclosed methods and computer readable medium storing instructions for performing steps of the disclosed methods.Type: ApplicationFiled: July 15, 2019Publication date: January 2, 2020Inventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Marilou L. Coleman, Walter G. Stonas, Willie J. Cowart, Wenjing Li, Ema C. Olah
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Publication number: 20190301999Abstract: The present disclosure provides methods for automated slide assessments made in conjunction with digital image-based microscopy. Automated methods of acquiring patient information and specimen information from prepared slides, and digitally linking such information into patient-tagged specimen data, are provided. Also provided are methods that include automatically identifying an optimal area for morphological assessment of a blood smear on a hematological slide, including methods for triggering the analysis of such an area, e.g., using an automated digital image-based hematology system. The present disclosure also provides devices, systems and computer readable media for use in performing processes of the herein described methods.Type: ApplicationFiled: May 23, 2019Publication date: October 3, 2019Inventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Kam Lin Wong, Damian John Verdnik, Leigh Whiting, Mahmoud Janbakhsh
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Patent number: 10395368Abstract: The present disclosure includes methods of assessing a histologically stained specimen based on a determined color signature of a region of interest of the specimen. Such assessments may be performed for a variety of purposes including but not limited to assessing the quality of the histological stain, as part of identifying one or more biologically relevant features of the image, as part of differentiating one feature of the image from other features of the image, identifying an anomalous area of the stained specimen, classifying cells of the specimen, etc. Also provided are systems configured for performing the disclosed methods and computer readable medium storing instructions for performing steps of the disclosed methods.Type: GrantFiled: December 14, 2016Date of Patent: August 27, 2019Assignee: Abbott LaboratoriesInventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Marilou L. Coleman, Walter G. Stonas, Willie J. Cowart, Wenjing Li, Ema C. Olah
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Patent number: 10393997Abstract: Methods, systems and devices for automatically focusing a microscope on a specimen and collecting a focused image of the specimen are provided. Aspects of the methods include detecting the presence of a substrate in a microscope, determining whether the substrate is in a correct orientation for imaging, focusing the microscope on a specimen that is placed on the substrate, and collecting one or more images of the specimen. Systems and devices for carrying out the subject methods are also provided.Type: GrantFiled: February 11, 2016Date of Patent: August 27, 2019Assignee: Abbott LaboratoriesInventors: Trevor David Shields, Robert John Fahey, Damian John Verdnik, Svitlana Y. Berezhna, Mahmoud Janbakhsh, Koshy Thekkadathu Chacko
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Patent number: 10345218Abstract: The present disclosure provides methods for automated slide assessments made in conjunction with digital image-based microscopy. Automated methods of acquiring patient information and specimen information from prepared slides, and digitally linking such information into patient-tagged specimen data, are provided. Also provided are methods that include automatically identifying an optimal area for morphological assessment of a blood smear on a hematological slide, including methods for triggering the analysis of such an area, e.g., using an automated digital image-based hematology system. The present disclosure also provides devices, systems and computer readable media for use in performing processes of the herein described methods.Type: GrantFiled: December 5, 2017Date of Patent: July 9, 2019Assignee: ABBOTT LABORATORIESInventors: Svitlana Y. Berezhna, Rene Nieves Alicea, Kam Lin Wong, Damian John Verdnik, Leigh Whiting, Mahmoud Janbakhsh