Abstract: A real-time location system for identifying and locating tagged items. The system may include an identification protocol that tracks in-network transponders and assigns dynamic in-network identification numbers to in-network transponders. The system includes a locator function that employs time-of-arrival analysis. Rather than attempt to synchronize the time base at each reader, the system and process eliminate the need to sync the readers and also eliminate the impact of differential receive delays in the respective readers. Both the transponder and a master reader transmit locate signals, which are measured at slave readers. The system relies on differences in time-of-arrival of the two signals at the respective slave readers to determine the likely location of the transponder.