Patents by Inventor Swapan K. Samanta

Swapan K. Samanta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Stereochemically defined dipeptide esters of antiviral agents for enhanced ocular treatment
    Patent number: 7951774
    Abstract: Stereochemically defined dipeptide esters of nucleoside-analogous antiviral agents including acyclovir and ganciclovir are provided. Certain of these stereochemically defined dipeptide esters are found to have unexpectedly enhanced delivery to and uptake by ocular tissues, crossing the blood-ocular barrier more effectively than other stereochemically defined dipeptide esters. For example, (L-Val)-(D-Val)-acyclovir was found to be taken up more effectively into corneal tissue than were underivatized acyclovir, monoesters (L-Val)-acyclovir or (D-Val)-acyclovir, or diester (L-Val)-(L-Val)-acyclovir.
    Type: Grant
    Filed: November 25, 2008
    Date of Patent: May 31, 2011
    Assignee: The Curators of the University of Missouri
    Inventors: Ashim K. Mitra, Swapan K. Samanta, Ravi S. Talluri
  • STEREOCHEMICALLY DEFINED DIPEPTIDE ESTERS OF ANTIVIRAL AGENTS FOR ENHANCED OCULAR TREATMENT
    Publication number: 20090149482
    Abstract: Stereochemically defined dipeptide esters of nucleoside-analogous antiviral agents including acyclovir and ganciclovir are provided. Certain of these stereochemically defined dipeptide esters are found to have unexpectedly enhanced delivery to and uptake by ocular tissues, crossing the blood-ocular barrier more effectively than other stereochemically defined dipeptide esters. For example, (L-Val)-(D-Val)-acyclovir was found to be taken up more effectively into corneal tissue than were underivatized acyclovir, monoesters (L-Val)-acyclovir or (D-Val)-acyclovir, or diester (L-Val)-(L-Val)-acyclovir.
    Type: Application
    Filed: November 25, 2008
    Publication date: June 11, 2009
    Inventors: Ashim K. Mitra, Swapan K. Samanta, Ravi S. Talluri