Abstract: The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, in combination with enzyme replacement therapies, as well as methods of making and using the same.

Abstract: The present disclosure relates to polypeptides, such as fibronectin type III (FN3) domains that can bind EpCAM, their conjugates, isolated nucleotides encoding the molecules, vectors, host-cells, as well as methods of making and using the molecules.

Abstract: The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules.

Abstract: The present disclosure relates to polypeptides, such as fibronectin type III (FN3) domains that can bind CD71, their conjugates, isolated nucleotides encoding the molecules, vectors, host-cells, as well as methods of making and using the same.

Abstract: Techniques are disclosed for classifying a user search query for a database system. In disclosed techniques, a computing system receives a user search query for the database system and determines, based on the user search query, a database query that is compatible with an interface of the database system to implement the user search query. In some embodiments, the computing system causes a query remediation interface to be presented to a user that entered the user search query. In some embodiments, the interface includes: a classification of the user search query that specifies attributes of the database query, and one or more elements selectable to alter the database query. The computing system receives, from the user via the query remediation interface, input for altering the database query and determines an updated database query based on the input. The computing system may access the database system using the updated database query.

Abstract: The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules.

Abstract: The present disclosure relates to polypeptides, such as fibronectin type III (FN3) domains that can bind CD71, their conjugates, isolated nucleotides encoding the molecules, vectors, host-cells, as well as methods of making and using the same.

Abstract: An isolation mount assembly includes a rubber isolator formed to be seated within an aperture in a supported member, with an extension located on an exterior surface of the isolator; and includes a washer containing an aperture corresponding with a location of the extension. The isolator may include a through-hole and an inner sleeve, and be seated within a supported member. A method for temporarily securing a washer to a rubber isolator includes aligning an aperture in the washer to a corresponding securing feature on the isolator, inserting the securing feature through the aperture, pulling a detached end of the securing feature, pushing the washer towards the isolator until it makes contact with the surface of the isolator, and releasing the detached end of the securing feature. An exemplary method may include trimming or deforming an excess part of the extension after releasing the detached end.

Abstract: The present disclosure relates to compositions, such as siRNA molecules and FN3 domains conjugated to the same, as well as methods of making and using the molecules.

Abstract: Techniques are disclosed for classifying a user search query for a database system. In disclosed techniques, a computing system receives a user search query for the database system and determines, based on the user search query, a database query that is compatible with an interface of the database system to implement the user search query. In some embodiments, the computing system causes a query remediation interface to be presented to a user that entered the user search query. In some embodiments, the interface includes: a classification of the user search query that specifies attributes of the database query, and one or more elements selectable to alter the database query. The computing system receives, from the user via the query remediation interface, input for altering the database query and determines an updated database query based on the input. The computing system may access the database system using the updated database query.

Abstract: An isolation mount assembly includes a rubber isolator formed to be seated within an aperture in a supported member, with an extension located on an exterior surface of the isolator; and includes a washer containing an aperture corresponding with a location of the extension. The isolator may include a through-hole and an inner sleeve, and be seated within a supported member. A method for temporarily securing a washer to a rubber isolator includes aligning an aperture in the washer to a corresponding securing feature on the isolator, inserting the securing feature through the aperture, pulling a detached end of the securing feature, pushing the washer towards the isolator until it makes contact with the surface of the isolator, and releasing the detached end of the securing feature. An exemplary method may include trimming or deforming an excess part of the extension after releasing the detached end.

Abstract: The present invention discloses a novel process for preparation of carvedilol by using eco friendly solvents to obtain the said carvedilol in high purity. The said process comprises, reacting 4-hydroxy carbazole of formula (IV) with epichlorhydrin in presence of an organic solvent and a base at temperatures between 10° C.-30° C.; further reacting the resultant 4-(2,3-epoxypropoxy)- carbazole of formula (II) with a salt of 2-(2-methoxyphenoxy)ethylamine of formula (III), preferably hydrochloride salt in presence of a base and a hydroxylic solvent at temperatures between 30° C.-90° C.