Abstract: Provided herein are compounds and compositions thereof that may be capable of disrupting, interrupting, and/or preventing an interaction between a small GTPase protein and a PI3K protein (e.g., PI3Ka). The present disclosure also provides methods of treating cancers and other indications with such compounds or compositions thereof.

Abstract: A disclosed method may include receiving user information for electronically filing or updating an electronic data sheet that corresponds to a user and a domain; maintaining a record of past electronic activities by the user; electronically receiving interchange data associated with interchanges executed by the user; automatically generating the electronic data sheet for the user based on the user information and the interchange data, the electronic data sheet indicating a finalized amount of resources to be transmitted to the domain; and electronically adjusting an electronic value for the user according to a remittance risk determination that is based on the interchange data and the record of past electronic activities by the user, the adjusted electronic value indicating a maximum amount of resources for which an online software platform will transmit and receive protocols to enable providing by the online software platform the maximum amount of resources.

Abstract: Systems and methods are disclosed for automated preparation and transmission of electronic registrations, data sheets and resources. This may include electronically initiating a process to collect data via a graphical user interface (GUI) to facilitate automated preparation of an electronic registration, including electronically obtaining a pre-existing entity identifier. The system may use the entity identifier to perform automated actions to electronically collect one or more support content. The system may generate the electronic registration based on the one or more support content and also receives interchange data. The system then automatically generates an electronic data sheet based on the registration and interchange data. The system may then electronically file the generated electronic data sheet, electronically issuing an alert to electronically request additional resources and automatically transmitting the finalized amount of resources to the domain.