Patents by Inventor Swarnalatha Akuratiya Gamage

Swarnalatha Akuratiya Gamage has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10888567
    Abstract: Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
    Type: Grant
    Filed: August 12, 2015
    Date of Patent: January 12, 2021
    Assignee: Auckland UniServices Limited
    Inventors: Brian Desmond Palmer, Lai Ming Ching, Swarnalatha Akuratiya Gamage
  • Publication number: 20200017491
    Abstract: Fibroblast Growth Factor Receptor kinase inhibitors and prodrugs thereof of Formula (I) and their use for the treatment of hyper-proliferative diseases such as retinopathy, psoriasis, rheumatoid arthritis, osteoarthritis, septic arthritis, tumour metastasis, periodontal disease, corral ulceration, proteinuria, coronary thrombosis from atherosclerotic plaque, aneurismal aorta, dystrophobic epidermolysis bullosa, degenerative cartilage loss following traumatic joint injury, osteopenias mediated by MMP activity, tempero mandibular joint disease, and demyelating disease of the nervous system.
    Type: Application
    Filed: March 2, 2018
    Publication date: January 16, 2020
    Applicants: Auckland Uniservices Limited, Guangzhou Intitute of BioMedicine and Health
    Inventors: Adam Vorn PATTERSON, Jeffrey Bruce SMAILL, Amir ASHOORZADEH, Christopher Paul GUISE, Christopher John SQUIRE, Swarnalatha Akuratiya GAMAGE, Maria Rosaria ABBATTISTA, Matthew Roy BULL, Angus Cheverton GREY, Xueqiang LI, Ke DING, Xiaomei REN, Shuang JIANG, Zhengchao TU
  • Publication number: 20190276423
    Abstract: Disclosed are tricyclic heterocyclic compounds having kinase inhibitory activity, pharmaceutical compositions and kits comprising the compounds, and use of the compounds in the treatment of or in medicaments for the treatment of various diseases and conditions. In particular, disclosed are tricyclic heterocyclic compounds of the formula (I) having CSF-1R (c-FMS kinase) inhibitory activity and their use in the treatment of various diseases and conditions, such as those mediated by CSF-1R, including proliferative or neoplastic diseases and conditions, including cancers, and bone, inflammatory, and autoimmune diseases and conditions.
    Type: Application
    Filed: November 3, 2017
    Publication date: September 12, 2019
    Applicant: AUCKLAND UNISERVICES LIMITED
    Inventors: Swarnalatha Akuratiya GAMAGE, Peter Robin SHEPHERD, Jack Urquhart FLANAGAN, Gordon William REWCASTLE, Andrew James MARSHALL, Christina Maree BUCHANAN, Guo-Liang LU, Muriel BONNET, Stephen Michael Frazer JAMIESON, William Alexander DENNY
  • Publication number: 20190169113
    Abstract: pa The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treating pain. The present invention also relates to methods for anaesthetizing and methods for sedating a subject comprising administering ketamine derivatives of the formula (II).
    Type: Application
    Filed: February 6, 2019
    Publication date: June 6, 2019
    Inventors: James Wallace Sleigh, William Alexander Denny, Jiney Jose, Swarnalatha Akuratiya Gamage, Martyn Gregory Harvey, Logan James Voss
  • Patent number: 10239825
    Abstract: The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treating pain. The present invention also relates to methods for anaesthetizing and methods for sedating a subject comprising administering ketamine derivatives of the formula (II).
    Type: Grant
    Filed: March 20, 2017
    Date of Patent: March 26, 2019
    Assignee: Auckland Uniservices Limited
    Inventors: James Wallace Sleigh, William Alexander Denny, Jiney Jose, Swarnalatha Akuratiya Gamage, Martyn Gregory Harvey, Logan James Voss
  • Publication number: 20170224701
    Abstract: Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR1, N or N-oxide; X is CR2, N or N-oxide; Y is CR3, N or N-oxide; Z is CR4, N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and R10 are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.
    Type: Application
    Filed: August 12, 2015
    Publication date: August 10, 2017
    Inventors: Brian Desmond Palmer, Lai Ming Ching, Swarnalatha Akuratiya Gamage
  • Publication number: 20170190653
    Abstract: The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treating pain. The present invention also relates to methods for anaesthetizing and methods for sedating a subject comprising administering ketamine derivatives of the formula (II).
    Type: Application
    Filed: March 20, 2017
    Publication date: July 6, 2017
    Inventors: James Wallace Sleigh, William Alexander Denny, Jiney Jose, Swarnalatha Akuratiya Gamage, Martyn Gregory Harvey, Logan James Voss
  • Publication number: 20150259277
    Abstract: The present invention relates to ketamine derivatives of the formula (I), pharmaceutical compositions comprising them, and methods for treating pain comprising administering them, and their use in the manufacture of medicaments for treating pain. The present invention also relates to methods for anaesthetizing and methods for sedating a subject comprising administering ketamine derivatives of the formula (II).
    Type: Application
    Filed: October 8, 2013
    Publication date: September 17, 2015
    Inventors: James Wallace Sleigh, William Alexander Denny, Jiney Jose, Swarnalatha Akuratiya Gamage, Martyn Gregory Harvey, Logan James Voss
  • Patent number: 9108980
    Abstract: Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g., compounds of Formulae IA, IB, and IC, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.
    Type: Grant
    Filed: July 7, 2014
    Date of Patent: August 18, 2015
    Assignee: VETDC, INC.
    Inventors: Gordon William Rewcastle, Swarnalatha Akuratiya Gamage, Jack Urquhart Flanagan, Anna Claire Giddens, Kit Yee Tsang
  • Publication number: 20150038486
    Abstract: Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g., compounds of Formulae IA, IB, and IC, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.
    Type: Application
    Filed: July 7, 2014
    Publication date: February 5, 2015
    Inventors: Gordon William Rewcastle, Swarnalatha Akuratiya Gamage, Jack Urquhart Flanagan, Anna Claire Giddens, Kit Yee Tsang
  • Patent number: 8772287
    Abstract: Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g., compounds of Formulae IA, IB, and IC, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.
    Type: Grant
    Filed: June 10, 2013
    Date of Patent: July 8, 2014
    Assignee: VetDC, Inc.
    Inventors: Gordon William Rewcastle, Swarnalatha Akuratiya Gamage, Jack Urquhart Flanagan, Anna Claire Giddens, Kit Yee Tsang
  • Publication number: 20130289016
    Abstract: Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g., compounds of Formulae IA, IB, and IC, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.
    Type: Application
    Filed: June 10, 2013
    Publication date: October 31, 2013
    Inventors: Gordon William Rewcastle, Swarnalatha Akuratiya Gamage, Jack Urquhart Flanagan, Anna Claire Giddens, Kit Yee Tsang
  • Patent number: 8486939
    Abstract: Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazoles of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.
    Type: Grant
    Filed: July 6, 2010
    Date of Patent: July 16, 2013
    Assignee: Pathway Therapeutics Inc.
    Inventors: Gordon William Rewcastle, Kit Yee Tsang, Swarnalatha Akuratiya Gamage, Anna Claire Giddens
  • Patent number: 8461158
    Abstract: Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g., compounds of Formulae IA, IB, and IC, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.
    Type: Grant
    Filed: March 26, 2010
    Date of Patent: June 11, 2013
    Assignee: Pathway Therapeutics Inc.
    Inventors: Gordon William Rewcastle, Swarnalatha Akuratiya Gamage, Jack Urquhart Flanagan, Anna Claire Giddens, Kit Yee Tsang
  • Publication number: 20110053907
    Abstract: Provided herein are substituted pyrimidine and triazine derivatives, including bicyclic pyrimidine derivatives, their pharmaceutical compositions, their preparation, and their use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs. In one embodiment, the pyrimidine and triazine derivatives are morpholino-pyrimidine, morpholino-triazine, pyridyl-pyrimidine, and pyridyl-triazine derivatives which are selective irreversible inhibitors of the p110? isoform of PI3K.
    Type: Application
    Filed: March 26, 2009
    Publication date: March 3, 2011
    Applicant: Auckland UniServices Limited
    Inventors: Gordon William Rewcastle, Peter Robin Shepherd, Glaire Chaussade, William Alexander Denny, Swarnalatha Akuratiya Gamage
  • Publication number: 20110009405
    Abstract: Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazoles of Formula I, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.
    Type: Application
    Filed: July 6, 2010
    Publication date: January 13, 2011
    Applicant: Pathway Therapeutics Limited
    Inventors: Gordon William Rewcastle, Kit Yee Tsang, Swarnalatha Akuratiya Gamage, Anna Claire Giddens
  • Publication number: 20100249099
    Abstract: Provided herein are pyrimidinyl and 1,3,5-triazinyl benzimidazole sulfonamides, e.g., compounds of Formulae IA, IB, and IC, and their pharmaceutical compositions, preparation, and use as agents or drugs for cancer therapy, either alone or in combination with radiation and/or other anticancer drugs.
    Type: Application
    Filed: March 26, 2010
    Publication date: September 30, 2010
    Applicant: Pathway Therapeutics Limited
    Inventors: Gordon William Rewcastle, Swarnalatha Akuratiya Gamage, Jack Urquhart Flanagan, Anna Claire Giddens, Kit Yee Tsang
  • Publication number: 20040192686
    Abstract: The present invention relates to a synergetistic composition comprising one or more benzoazine-mono-N-oxides, and one or more benzoazine 1,4 dioxides for use in cancer therapy.
    Type: Application
    Filed: January 30, 2004
    Publication date: September 30, 2004
    Applicant: Auckland Uniservices Limited
    Inventors: William Robert Wilson, Frederik Bastiaan Pruijn, Bronwyn Gae Siim, Michael Patrick Hay, William Alexander Denny, Swarnalatha Akuratiya Gamage
  • Patent number: 6552021
    Abstract: A compound which is a heteroaromatic[a]phenazine carboxamide derivative of formula (I) wherein X is a five- or six-membered heteroaromatic ring which contains one or two nitrogen atoms and which is unsubstituted or substituted by C1-C6 alkyl, hydroxyl or C1-C6 alkoxy; Q is C1-C6 alkylene which is unsubstituted or substituted by C1-C6 alkyl which is unsubstituted or substituted by a hydroxy group; and R1 and R2 which are the same or different are each C1-C6 alkyl; or a pharmaceutically acceptable salt thereof. These compounds are inhibitors of topoisomerase I and II and can be used to treat tumours, including tumours which express MDR.
    Type: Grant
    Filed: March 5, 2001
    Date of Patent: April 22, 2003
    Assignee: Xenova Limited
    Inventors: John Milton, Nigel Vicker, William Alexander Denny, Swarnalatha Akuratiya Gamage, Julie Ann Spicer
  • Publication number: 20010034346
    Abstract: A compound which is a heteroaromatic[a]phenazine carboxamide derivative of formula (I) 1
    Type: Application
    Filed: March 5, 2001
    Publication date: October 25, 2001
    Inventors: John Milton, Nigel Vicker, William Alexander Denny, Swarnalatha Akuratiya Gamage, Julie Ann Spicer