Abstract: A method of treating a cancer selected from the group consisting of a myeloid malignancy, a lymphoid malignancy and Ewing's sarcoma is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent that inhibits the synthesis and/or activity of cortisol.

Abstract: Disclosed herein are compounds of formula I: (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, and R3 may any of the values defined herein, as well as compositions comprising such compounds. Also disclosed are methods for treating diseases including neurodegenerative disorders such as Parkinson's Disease and Alzheimer's Disease.

Abstract: A provenance method, system, and non-transitory computer readable medium for a plurality of eidetic systems having logs, include crawling the logs of each node of a plurality of nodes of the eidetic systems to cluster segments across the logs of temporally correlated events into clustered segments and analyzing the correlated segments to interleave an order of processes in the logs and assign a probability to the order of the processes occurring.

Abstract: According to various embodiments described herein, a microfluidics-chip based purification device and system for Sanger-sequencing reactions is provided. The device and system allow for the introduction into a sequencing system of a cartridge containing purification technologies specific to the sequencing contaminants or sequencing method where the simplified purification solution of a cartridge allows automation of the sample purification process, reduced consumption of purification reagents, and consistency in sampling by reducing the sampling errors and artifacts. These various embodiments therefore solve the need for a microfluidics-chip-based, Sanger-sequencing reaction purification system for CE devices. The microfluidic chips described can be used as a PCR chip by reorganizing the on-chip reagents, reaction wells and work flow steps.

Abstract: An imaging system includes a sensor array of differential pixels. A controller operates a first differential pixel of the sensor array in a first, lower power mode. The controller supplies a first clock signal to selectively activate a first collection terminal of the first differential pixel for a first duration, and a second clock signal to selectively activate a second collection terminal of the first differential pixel for a second duration. In an analog domain, a first amount of charge accumulated at the first collection terminal over the first duration is readout and compared to a readout of a second amount of charge accumulated at the second collection terminal over the second duration. Responsive to the first amount of charge being different from the second amount of charge by more than a threshold, the first differential pixel of the sensor array is operated in a second, higher power mode.

Abstract: In general, the disclosed technology relates to a method for generating a web application. The method includes selecting a webpage in the web application and implementing a custom user interface (UI) action on the webpage. Implementing the custom UI action on the webpage may include creating a hidden component on the webpage, associating a custom UI action with the hidden component, specifying at least one input for the hidden component based on the custom UI action, specifying at least one target output for the hidden component based on the custom UI action, and associating the hidden component with a custom UI action trigger event. The method further includes deploying the web application after implementing the custom UI action on the webpage.

Abstract: Methods and system for item matching are described. In one embodiment, compatibility-based text for an item may be accessed. A compatibility identifier may be identified based on the compatibility-based text. The compatibility identifier may be associated with an item cluster. The compatibility identifier may be used to identify a plurality of matching items. A result may be provided based on identification of the plurality of matching items. Additional methods and systems are disclosed.

Abstract: A document is received, the document including metadata for a data visualization of a data set. The data set includes a plurality of data columns, each of the plurality of columns having a column name and a plurality of data values. A first set of columns of the plurality of columns is present in the data visualization. The first set of columns is determined based on the metadata. A second set of columns of the plurality of columns is determined, where the second set of columns includes remaining columns of the plurality of columns excluding the first set of columns. The data set is ordered by having the first set of columns prior to the second set of columns. A composite index is generated on the ordered data set.

Abstract: A system including a first cylindrical structure embedded into a second cylindrical structure. The first cylindrical structure includes a combustion chamber. The first cylinder additionally includes a plurality of plasmonic materials on an outer wall of the first cylindrical structure. The second cylindrical structure includes a plurality of photovoltaic cells on an inner wall of the second cylindrical structure. A radius of the second cylindrical structure is greater than a radius of the first cylindrical structure.

Abstract: A system includes a computing device configured to obtain item attribute data that corresponds to a characteristic of an item ordered by a customer on an e-commerce platform and a common characteristic of a plurality of substitution items. The computing device is also configured to obtain customer attribute data identifying preferences of the customer and to determine a preference score for each substitution item in the plurality of substitution items based on the item attribute data and the customer attribute data. The preference score indicates a likelihood that the customer will accept one of the plurality of substitution items as a replacement for the item ordered by the customer. The computing device is also configured to rank each substitution item in the plurality of substitution items based on the preference scores.

Abstract: According to some embodiments, an automated provisioning system may receive a customer demand associated with an application to be executed in a cloud-based computing environment. The automated provisioning system may include a process allocator to communicate with Virtual Machine (“VM”) and container provisioners and determine cluster data. A machine learning based microservice setup platform, coupled to the automated provisioning system, may receive the cluster data and information about the customer demand. The machine learning based microservice setup platform may then execute policy rules based on the cluster data (and information about the customer demand) and generate a recommendation for the customer demand. The automated provisioning system may then assign the customer demand to one of a VM-based infrastructure and a container-based infrastructure in accordance with the recommendation generated by the machine learning based microservice setup platform.

Abstract: Liquid dosage forms of Aprepitant are not much explored. The present invention describes ready to use, oral liquid compositions of Aprepitant suitable for the patients having swallowing difficulties. The liquid compositions of the present invention are storage stable for prolonged time and can be used for the prevention and control of acute and delayed chemotherapy induced nausea and vomiting, and for the prevention of postoperative nausea and vomiting.

Abstract: According to some embodiments, a centralized resource provisioning system may associated with a plurality of end-user applications in a cloud-based computing environment. The centralized resource provisioning system may include a policy decision maker that generates a centralized recommendation for a computing resource of a first end-user application. An application decision maker may be associated with the first end-user application and generate a decentralized recommendation for the computing resource of the first end-user application. A machine controller of the centralized resource provisioning system may then arrange to adjust the computing resource for the first end-user application when both the centralized recommendation and the decentralized recommendation indicate that the adjustment is appropriate.

Abstract: A provenance method, system, and non-transitory computer readable medium for a plurality of eidetic systems having logs, include a log-segment clustering circuit configured to crawl the logs of each of the eidetic systems to cluster segments across the logs of temporally correlated events into clustered segments, a probabilistic interleaving circuit configured to analyze the correlated segments to interleave an order of processes in the logs and assign a probability to the order of the processes occurring, and a probabilistic linearization circuit configured to create a probability tree which includes a total probability that a process in the clustered segments causes a next process in the clustered segments until an end of the temporal event of the clustered segments for each of the interleaved order of processes interleaved by the probabilistic interleaving circuit.

Abstract: Nowadays shopping in supermarkets, malls, marts and other commercial places becomes a very important part of human life. Apart from just shopping, these places offer so many entertainment platforms for every age group of people under one roof. Therefore, to attract the customers, the shop owners are always trying to introduce unique flavour in their shopping platforms, such as: Digital Payment methods, Automatic controlling systems, location indicator of the particular store, Smart Trolley and etc. Shopping Trolley is always hidden but a very crucial part of your shopping. Here, we are putting this hidden component into the central attraction for the shopping. In our proposed invention idea (Smart Trolley), we are planning to put so many customer friendly features into the trolley, which takes the customer's shopping experience into another level.

Abstract: A device may receive video data associated with a video, and may identify image data associated with the video data and that corresponds to a frame of the video. The device may process the image data, with an image analysis model, to determine an image compliance score associated with a policy and with context of the image data, and may identify text data associated with the video data. The device may process the text data, with a text analysis model, to determine a text compliance score associated with the policy and with context of the text data, and may determine, based on the image compliance score and the text compliance score, an aggregate compliance score associated with the frame. The device may determine whether the aggregate compliance score satisfies a threshold associated with the policy, and may perform actions based on whether the aggregate compliance score satisfies the threshold.

Abstract: A gas analyzer includes a sample inlet, a sample outlet, a detector, a monitoring component, and a controller. The sample inlet is configured to receive a sample and is coupled to the sample outlet. The detector is operably disposed between the sample inlet and the sample outlet and is configured to provide an indication relative to the sample. The monitoring component is configured to provide a diagnostic indication regarding at least one component of the gas analyzer. The controller is configured to control flow through the gas analyzer and is operably coupled to the detector to analyze the sample, provide the analysis to the monitoring component, and provide the indication of health to an output.

Abstract: A mid-tier messaging system receives a request to initiate a communication session via a first messaging channel that includes a first messaging interface of a first messaging application provided at a user device and a first message provider of a plurality of message providers. The mid-tier messaging system establishes a first session that is mapped to the communication session. The mid-tier messaging system establishes the communication, using the first session, between the first messaging interface and the first message provider. The mid-tier messaging system provides, through the first session, first message communications between the first message provider and the first messaging interface. The mid-tier messaging system seamlessly switches to a second message provider service when the first message provider service cannot service an intent of the first communication session.

Abstract: Examples of a content alignment system are provided. The system may receive a content record and a content creation requirement. The system may implement an artificial intelligence component to sort the content record into a plurality of objects and for identifying an object boundary for each of the plurality of objects. The system may identify a plurality of images and implement a first cognitive learning operation to identify an image boundary for each of the plurality of images. The system may identify a plurality of exhibits and implement a second cognitive learning operation to identify a data pattern associated with each of the plurality of exhibits. The system may implement a third cognitive learning operation for determining a content creation model by evaluating the plurality of objects, the plurality of images, and the plurality of exhibits. The system may generate a content creation output to resolve the content creation requirement.