Patents by Inventor Sy-Jye Leu

Sy-Jye Leu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11485776
    Abstract: The invention provides anti-CaENO1 antibodies and humanized antibodies as effective diagnostic agent or therapeutic treatment against infections caused by Candida spp. (preferably Candida. albicans, Candida tropicalis), fluconazole resistance Candida spp., Streptococcus, or Staphylococcus.
    Type: Grant
    Filed: July 23, 2020
    Date of Patent: November 1, 2022
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Sy-Jye Leu, Yi-Yuan Yang, Yu-Ching Lee, Ching-Hua Su, Ko-Jiunn Liu, Hsiu-Jung Lo, Yun-Liang Yang
  • Publication number: 20210079072
    Abstract: The invention provides anti-CaENO1 antibodies and humanized antibodies as effective diagnostic agent or therapeutic treatment against infections caused by Candida spp. (preferably Candida. albicans, Candida tropicalis), fluconazole resistance Candida spp., Streptococcus, or Staphylococcus.
    Type: Application
    Filed: July 23, 2020
    Publication date: March 18, 2021
    Inventors: Sy-Jye LEU, Yi-Yuan YANG, Yu-Ching LEE, Ching-Hua SU, Ko-Jiunn LIU, Hsiu-Jung LO, Yun-Liang YANG
  • Patent number: 10766951
    Abstract: Anti-CaENO1 antibodies and humanized antibodies are provided as an effective diagnostic agent or a therapeutic treatment against infections caused by Candida spp., preferably Candida albicans, Candida tropicalis, fluconazole resistance Candida spp., Streptococcus, Staphylococcus.
    Type: Grant
    Filed: April 1, 2016
    Date of Patent: September 8, 2020
    Assignee: TAIPEI MEDICAL UNIVERSITY
    Inventors: Sy-Jye Leu, Yi-Yuan Yang, Yu-Ching Lee, Ching-Hua Su, Ko-Jiunn Liu, Hsiu-Jung Lo, Yun-Liang Yang
  • Publication number: 20180319873
    Abstract: Anti-CaENO1 antibodies and humanized antibodies are provided as an effective diagnostic agent or a therapeutic treatment against infections caused by Candida spp., preferably Candida albicans, Candida tropicalis, fluconazole resistance Candida spp., Strepcococcus, Staphylococcus.
    Type: Application
    Filed: April 1, 2016
    Publication date: November 8, 2018
    Inventors: Sy-Jye LEU, Yi-Yuan YANG
  • Patent number: 9200262
    Abstract: The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
    Type: Grant
    Filed: March 9, 2011
    Date of Patent: December 1, 2015
    Assignees: TAIPEI MEDICAL UNIVERSITY, NATIONAL HEALTH RESEARCH INSTITUTE
    Inventors: Sy-Jye Leu, Neng-Yao Shih, Yi-Yuan Yang, Ko-Jiunn Liu, I-Jen Huang, Yuan-Soon Ho, Suparat Charoenfuprasert, Yu-Ching Lee
  • Patent number: 8449881
    Abstract: The invention relates to antibodies against ?-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-?-enolase I antibodies and monoclonal single-chain variable fragment (scFv) anti-?-enolase antibodies, pharmaceutical compositions containing the same and their uses in uses in diagnosis and treatment of cancers, autoimmune disorders, ischemia and bacterial infection.
    Type: Grant
    Filed: January 28, 2010
    Date of Patent: May 28, 2013
    Assignee: Taipei Medical University
    Inventors: Sy-Jye Leu, Yi-Yuan Yang, Neng-Yao Shih, I-Jen Huang, Ko-Jiunn Liu, Yu-Ching Lee, Yung-Leun Shih, Yu-Jia Chang, Bor-Yu Tsai, Yuan-Soon Ho
  • Patent number: 8361441
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
    Type: Grant
    Filed: September 29, 2009
    Date of Patent: January 29, 2013
    Assignee: Taipei Medical University
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yung-Luen Shih, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • Publication number: 20110182907
    Abstract: The invention relates to antibodies against ?-enolase I, their pharmaceutical compositions and diagnosis and treatment uses. Particularly, the invention provides polyclonal anti-?-enolase I antibodies and monoclonal single-chain variable fragment (scFv) anti-?-enolase antibodies, pharmaceutical compositions containing the same and their uses in uses in diagnosis and treatment of cancers, autoimmune disorders, ischemia and bacterial infection.
    Type: Application
    Filed: January 28, 2010
    Publication date: July 28, 2011
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Sy-Jye Leu, Yi-Yuan Yang, Neng-Yao Shih, I-Jen Huang, Ko-Jiunn Liu, Yu-Ching Lee, Yung-Leun Shih, Yu-Jia Chang, Bor-Yu Tsai, Yuan-Soon Ho
  • Publication number: 20110159518
    Abstract: The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
    Type: Application
    Filed: March 9, 2011
    Publication date: June 30, 2011
    Applicants: TAIPEI MEDICAL UNIVERSITY, NATIONAL HEALTH RESEARCH INSTITUTE
    Inventors: Sy-Jye Leu, Neng-Yao Shih, Yi-Yuan Yang, Ko-Jiunn Liu, I-Jen Huang, Yuan-Soon Ho, Suparat Charoenfuprasert, Yu-Ching Lee
  • Patent number: 7928188
    Abstract: The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
    Type: Grant
    Filed: October 30, 2008
    Date of Patent: April 19, 2011
    Assignee: Taipei Medical University
    Inventors: Sy-Jye Leu, Neng-Yao Shih, Yi-Yuan Yang, Ko-Jiunn Liu, I-Jen Huang, Yuan-Soon Ho, Suparat Charoenfuprasert, Yu-Ching Lee
  • Patent number: 7807139
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
    Type: Grant
    Filed: January 23, 2009
    Date of Patent: October 5, 2010
    Assignee: Taipei Medical University
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Ching-Yu Lin, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yueh-Lun Lee, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • Publication number: 20100111956
    Abstract: The invention provides an isolated antigen polypeptide that can be expressed in a subject with ovarian cancer. Also provided is the diagnosis of ovarian cancer by using the antigen polypeptide of the invention and the prevention and/or treatment of ovarian cancer by suppressing the gene of the antigen polypeptide of the invention.
    Type: Application
    Filed: October 30, 2008
    Publication date: May 6, 2010
    Applicants: TAIPEI MEDICAL UNIVERSITY, NATIONAL HEALTH RESEARCH INSTITUTE
    Inventors: Sy-Jye Leu, Neng-Yao Shih, Yi-Yuan Yang, Ko-Jiunn Liu, I-Jen Huang, Yuan-Soon Ho, Suparat Charoenfuprasert, Yu-Ching Lee
  • Publication number: 20100087373
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by Enterobacteriaceae bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal. An antibody and a kit on the basis of the vaccinating method and detecting/diagnosing method are also provided.
    Type: Application
    Filed: September 29, 2009
    Publication date: April 8, 2010
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Ching-Yu Lin, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yung-Luen Shih, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • Patent number: 7608247
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.
    Type: Grant
    Filed: March 11, 2008
    Date of Patent: October 27, 2009
    Assignee: Taipei Medical University
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, I-Jen Huang, Neng-Yao Shih, Ko-Jiunn Liu, Mei-Ru Chen, Wen-Shyang Hsieh, Chi-Hsin Lee
  • Publication number: 20090232852
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection caused by klebsiella pneumoniae and other gram-negative bacteria in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided are a method for vaccinating a mammal to produce an antibody against bacterial infection caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation and a method of detecting or diagnosing bacterial infections caused by Enterobacteriaceae family in central nervous system and/or peripheral blood circulation in a mammal.
    Type: Application
    Filed: January 23, 2009
    Publication date: September 17, 2009
    Applicant: Taipei Medical University
    Inventors: Yi-Yuan Yang, Hsueh-Hsia Wu, Sy-Jye Leu, Neng-Yao Shih, I-Jen Huang, Ching-Yu Lin, Wen-Shyang Hsieh, Ko-Jiunn Liu, Shih-Yi Huang, Yueh-Lun Lee, Chi-Hsin Lee, Yuan-Soon Ho, Shih-Lan Hsu
  • Publication number: 20090233853
    Abstract: The present invention provides a method for the treatment and/or prevention of bacterial infection in central nervous system and/or peripheral blood circulation in a mammal by administering effective amount of outer membrane protein A (OmpA) or its derivatives to a mammal. Also provided is an antibody binding to OmpA that can assay OmpA levels in a biological sample and detect or diagnose bacterial infection in central nervous system and/or peripheral blood circulation.
    Type: Application
    Filed: March 11, 2008
    Publication date: September 17, 2009
    Applicant: TAIPEI MEDICAL UNIVERSITY
    Inventors: Yi-Yuan YANG, Hsueh-Hsia WU, Sy-Jye LEU, I-Jen HUANG, Neng-Yao SHIH, Ko-Jiunn LIU, Mei-Ru CHEN, Wen-Shyang HSIEH, Chi-Hsin LEE