Patents by Inventor Sybille Ebert

Sybille Ebert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the optimization of chromatographic purification processes for biological molecules
    Patent number: 8349615
    Abstract: The invention relates to a method of finding suitable parameters for the chromatographic purification of biomolecules. The method consists of equilibration, charging, washing and eluting steps, this sequence of steps being carried out by the partial batch method. The parameters determined in small, preferably numerous parallel test batches provide conclusions as to the chromatography conditions under which a given biomolecule can be purified optimally by column chromatography, optionally even on a larger scale.
    Type: Grant
    Filed: June 13, 2007
    Date of Patent: January 8, 2013
    Assignee: Boehringer Ingelheim Pharma GmbH & Co. KG
    Inventors: Christian Eckermann, Sybille Ebert, Stefanie Rubenwolf, Dorothee Ambrosius
  • Mutant GTP cyclohydrolase II enzymes
    Patent number: 7989189
    Abstract: The present invention relates to modified GTP cyclohydrolase II enzymes that display increased specific activity, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing riboflavin, a riboflavin precursor, FMN, FAD, or a derivative thereof.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: August 2, 2011
    Assignee: DSM IP Assets B.V.
    Inventors: Sybille Ebert, Hans-Peter Hohnmann, Martin Lehmann, Nigel John Mouncey, Markus Wyss
  • Enzymes
    Publication number: 20080193998
    Abstract: The present invention relates to modified GTP cyclohydrolase II enzymes that display increased specific activity, and to polynucleotides encoding them. The invention further pertains to vectors comprising these polynucleotides and host cells containing such vectors. The invention provides a method for producing the modified enzyme and a method for producing riboflavin, a riboflavin precursor, FMN, FAD, or a derivative thereof.
    Type: Application
    Filed: July 7, 2005
    Publication date: August 14, 2008
    Inventors: Sybille Ebert, Hans-Peter Hohnmann, Martin Lehmann, Nigel John Mouncey, Markus Wyss
  • Method for the Optimization of Chromatographic Purification Processes for Biological Molecules
    Publication number: 20080066530
    Abstract: The invention relates to a method of finding suitable parameters for the chromatographic purification of biomolecules. The method consists of equilibration, charging, washing and eluting steps, this sequence of steps being carried out by the partial batch method. The parameters determined in small, preferably numerous parallel test batches provide conclusions as to the chromatography conditions under which a given biomolecule can be purified optimally by column chromatography, optionally even on a larger scale.
    Type: Application
    Filed: June 13, 2007
    Publication date: March 20, 2008
    Inventors: Christian ECKERMANN, Sybille Ebert, Stefanie Rubenwolf, Dorothee Ambrosius