Patents by Inventor Sybille Müller

Sybille Müller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRANS-MEMBRANE-ANTIBODY INDUCED INHIBITION OF APOPTOSIS
    Publication number: 20120135012
    Abstract: Cell suicide (apoptosis) is associated with pathogenesis, for example, it is the major cause for the loss of neurons in Alzheimer's disease. Caspase-3 is critically involved in the pathway of apoptosis. Superantibody (SAT)-trans-membrane technology has been used to produce antibodies against the caspase enzyme in an effort to inhibit apoptosis in living cells. The advantage of using trans-membrane antibodies as apoptosis inhibitors is their specific target recognition in the cell and their lower toxicity compared to conventional apoptosis inhibitors. It is shown that a MTS-transport-peptide modified monoclonal anti-caspase-3 antibody reduces actinomycin D-induced apoptosis and cleavage of spectrin in living cells. These results indicate that antibodies conjugated to a membrane transporter peptide have a therapeutic potential to inhibit apoptosis in a variety of diseases.
    Type: Application
    Filed: November 22, 2011
    Publication date: May 31, 2012
    Applicant: InNexus Biotechnology Inc.
    Inventors: Heinz Kohler, Sybille Müller, Thomas L. Brown, Yunfeng Zhao, A. Charles Morgan
  • Anti-idiotypic antibody and its use in regulating the composition of T cell lymphocytes
    Patent number: 6916475
    Abstract: The present invention provides an anti-idiotypic antibody having specific reactivity with an idiotope common to more than one type of anti-HIV-1 antibody, and having no specific reactivity with non-HIV-1 antibodies. The present invention provides methods of diagnosis, monitoring and treatment of HIV-related diseases through the use of this antibody or related compounds.
    Type: Grant
    Filed: October 15, 2002
    Date of Patent: July 12, 2005
    Assignee: HEMA Diagnostic Systems L.L.C.
    Inventors: Sybille Müller, Haitao Wang
  • Nucleotide sequences encoding variable regions of heavy and light chains of monoclonal antibody 1F7, an anti-idiotypic antibody reactive with anti-HIV antibodies
    Patent number: 6768004
    Abstract: Nucleotide sequences encoding the variable heavy and light chains of the murine monoclonal antibody 1F7 are disclosed. The 1F7 antibody is an effective immune modulator that has anti-idiotypic binding affinity for anti-HIV antibodies. Polypeptides containing at least one complementarity-determining region (CDR) or framework-determining region (FR) of the variable heavy or variable light chains of 1F7, as well as the polynucleotides encoding them, can be used to modulate the immune response to HIV infection. Unnecessary, and potentially adverse, murine segments of the variable chains falling outside the CDRs can be replaced with human sequences to afford humanized chimeric antibodies and antibody fragments.
    Type: Grant
    Filed: January 11, 2001
    Date of Patent: July 27, 2004
    Inventors: Sybille Müller, Heinz Köhler
  • Anti-idiotypic antibody and its use in diagnosis and therapy in HIV-related disease
    Patent number: 6465173
    Abstract: The present invention provides an anti-idiotypic antibody having specific reactivity with an idiotope common to more than one type of anti-HIV-1 antibody, and having no specific reactivity with non-HIV-1 antibodies. The present invention provides methods of diagnosis, monitoring and treatment of HIV-related diseases through the use of this antibody or related compounds.
    Type: Grant
    Filed: July 25, 2001
    Date of Patent: October 15, 2002
    Assignee: Immune Research, Ltd.
    Inventors: Sybille Müller, Haitao Wang
  • Anti-idiotypic antibody and its use in diagnosis and therapy in HIV-related disease
    Patent number: 6461612
    Abstract: The present invention provides an anti-idiotypic antibody having specific reactivity with an idiotope common to more than one type of anti-HIV-1 antibody, and having no specific reactivity with non-HIV-1 antibodies. The present invention provides methods of diagnosis, monitoring and treatment of HIV-related diseases through the use of this antibody or related compounds.
    Type: Grant
    Filed: February 28, 2001
    Date of Patent: October 8, 2002
    Assignee: Immune Research, Ltd.
    Inventors: Sybille Müller, Haitao Wang
  • Anti-idiotypic and its uses in diagnosis and therapy in HIV-related disease
    Patent number: 6221580
    Abstract: The present invention provides an anti-idiotypic antibody having specific reactivity with an idiotope common to more than one type of anti-HIV-1 antibody, and having no specific reactivity with non-HIV-1 antibodies. The present invention provides methods of diagnosis, monitoring and treatment of HIV-related diseases through the use of this antibody or related compounds.
    Type: Grant
    Filed: July 5, 2000
    Date of Patent: April 24, 2001
    Assignee: Immune Network Research, Ltd.
    Inventors: Sybille Müller, Haitao Wang