Abstract: Described are photocurable liquid adhesives, kits for preparing photocurable liquid adhesives, and methods for their preparation and use. Kits can include first and second components that can be mixed to prepare a photocurable liquid adhesive. The first component can include a liquid preparation including an aqueous liquid, one or more polymers containing phenolic groups, and a photoactivatable metal ligand complex. The second component can include an electron acceptor. Mixing the first component and the second component can create a photocurable liquid adhesive. The first and second components can be packaged in containers such as syringes, and the kits can include the containers and a cannulated coupler for fluidly coupling the containers to mix the container contents to prepare the photocurable liquid adhesive. A syringe dispensing tip and/or a light source for curing the photocurable liquid adhesive can also be included in the kits.

Abstract: This invention relates to protein-based adhesives that are capable to adhere to a substrate in a dry, wet, moist, or an aqueous environment. Particularly, said adhesives comprise a crosslinking agent and an elastin-like polypeptide (ELP) that contain tyrosine, lysine, cysteine, dihydroxyphenylalanine (DOPA) or trihydroxyphenylalanine (TOPA) amino acid residue, or a combination thereof, on the polypeptide chain of said ELP. Among others, the adhesives disclosed herein may find broad applications in medical treatments and surgical operations. Compositions and methods of use are within the scope of this application.