Patents by Inventor Sydney E. Salmon
Sydney E. Salmon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 6090912Abstract: The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports. In particular, the invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. Each of the solid phase synthesis support beads contains a single type of synthetic test compound. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon--carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided.Type: GrantFiled: November 23, 1998Date of Patent: July 18, 2000Assignee: Selectide CorporationInventors: Michal Lebl, Kit S. Lam, Sydney E. Salmon, Victor Krchnak, Nikolai Sepetov, Peter Kocis
-
Patent number: 5858670Abstract: The instant invention provides a library of bio-oligomers of defined size and known composition, in which the library contains all of the possible sequences of the bio-oligomers, and a method of synthesis thereof. The bio-oligomers of the library may be peptides, nucleic acids, or a combination of the foregoing. The instant invention also provides methods to identify bio-oligomers from a library that demonstrate desired characteristics such as binding, bioactivity and catalytic activity. Thus the instant invention provides a unique and powerful method to identify a useful bio-oligomer sequences from a library more quickly than current state-of-the-art technology allows. Effector molecules for use in treatment or diagnosis of disease are also provided.Type: GrantFiled: October 23, 1996Date of Patent: January 12, 1999Assignee: The Arizona Board of RegentsInventors: Kit Sang Lam, Sydney E. Salmon
-
Patent number: 5840485Abstract: The invention relates to libraries of synthetic test compound attached to separate phase synthesis supports that also contain coding molecules that encode the structure of the synthetic test compound. The molecules may be polymers or multiple nonpolymeric molecules. The synthetic test compound can have backbone structures with linkages such as amide, urea, carbamate (i.e., urethane), ester, amino, sulfide, disulfide, or carbon-carbon, such as alkane and alkene, or any combination thereof. Examples of subunits suited for the different linkage chemistries are provided. The synthetic test compound can also be molecular scaffolds, such as derivatives of monocyclic of bicyclic carbohydrates, steroids, sugars, heterocyclic structures, polyaromatic structures, or other structures capable of acting as a scaffolding. Examples of suitable molecular scaffolds are provided.Type: GrantFiled: May 26, 1994Date of Patent: November 24, 1998Assignee: Selectide CorporationInventors: Michal Lebl, Kit S. Lam, Sydney E. Salmon, Victor Krchnak, Nikolai Sepetov, Peter Kocis
-
Patent number: 5651943Abstract: An apparatus and method are provided for the synthesis of compounds, e.g., oligomers or polymers, by the repeated steps of coupling various subunits onto solid supports. The apparatus has for a first member a vessel having chambers opening to a surface of the member, and has for a second member a vessel having a single chamber opening to a surface of the second member. The chambers preferably have filtered apertures to permit passage of gas or liquid while retaining the solid supports in the chambers. The first member is joined with the second member, forming a pair, such that the openings of the first member open into the second member. The first member is used for synthesis reactions and for holding unmixed compounds coupled to solid supports. The second member is used for mixing the solid supports. The solid supports are transferred from one member to another, e.g., by inverting the pair.Type: GrantFiled: July 11, 1994Date of Patent: July 29, 1997Assignee: Arizona Board of Regents, on behalf of the University of ArizonaInventors: Kit Sang Lam, Sydney E. Salmon
-
Patent number: 5650489Abstract: The instant invention provides a library of bio-oligomers of defined size and known composition, in which the library contains all of the possible sequences of the bio-oligomers, and a method of synthesis thereof. The bio-oligomers of the library may be peptides, nucleic acids, or a combination of the foregoing. The instant invention also provides methods to identify bio-oligomers from a library that demonstrate desired characteristics such as binding, bioactivity and catalytic activity. Thus the instant invention provides a unique and powerful method to identify a useful bio-oligomer sequences from a library more quickly than current state-of-the-art technology allows. Effector molecules for use in treatment or diagnosis of disease are also provided.Type: GrantFiled: June 19, 1991Date of Patent: July 22, 1997Assignee: The Arizona Board of RegentsInventors: Kit Sang Lam, Sydney E. Salmon
-
Patent number: 5510240Abstract: The instant invention provides a library of bio-oligomers of defined size and known composition, in which the library contains all of the possible sequences of the bio-oligomers, and a method of synthesis thereof. The bio-oligomers of the library may be peptides, nucleic acids, or a combination of the foregoing. The instant invention also provides methods to identify bio-oligomers from a library that demonstrate desired characteristics such as binding, bioactivity and catalytic activity. Thus the instant invention provides a unique and powerful method to identify a useful bio-oligomer sequences from a library more quickly than current state-of-the-art technology allows. Effector molecules for use in treatment or diagnosis of disease are also provided.Type: GrantFiled: February 8, 1993Date of Patent: April 23, 1996Assignee: The Arizona Board of RegentsInventors: Kit S. Lam, Sydney E. Salmon
-
Patent number: 5382513Abstract: The instant invention provides a library of bio-oligomers of defined size and known composition, in which the library contains all of the possible sequences of the bio-oligomers, and a method of synthesis thereof. The bio-oligomers of the library may be peptides, nucleic acids, or a combination of the foregoing. The instant invention also provides methods to identify bio-oligomers from a library that demonstrate desired characteristics such as binding, bioactivity and catalytic activity. Thus the instant invention provides a unique and powerful method to identify a useful bio-oligomer sequences from a library more quickly than current state-of-the-art technology allows. Effector molecules for use in treatment or diagnosis of disease are also provided.Type: GrantFiled: February 8, 1993Date of Patent: January 17, 1995Assignee: Bioligand Inc.Inventors: Kit S. Lam, Sydney E. Salmon
-
Patent number: 4411990Abstract: A bioassay method for supporting human tumor stem cell colony growth is disclosed. The method is suitable for culture of a variety of neoplasms of differing histopathology. Tumor stem cell colonies arising from different types of cancer have differing growth characteristics and colony morphology. The present bioassay may be employed in clinical studies of the effects of anticancer drugs or irradiation on human tumor stem cells.Type: GrantFiled: April 15, 1981Date of Patent: October 25, 1983Assignee: University Patents, Inc.Inventors: Sydney E. Salmon, Anne W. Hamburger
-
Patent number: 4057618Abstract: Radioiodinated bleomycin is a useful imaging agent for body tissues. Its production by reaction of bleomycin with N-hydroxysuccinimide esters of radioiodinated hydroxyphenylalkanoic acid is described.Type: GrantFiled: April 30, 1976Date of Patent: November 8, 1977Assignee: University Patents, Inc.Inventors: Sydney E. Salmon, Rosa H. Liu
-
Patent number: 4035155Abstract: Autoradiography using high specific activity tritiated thymidine (40-60 curies/millimole) and nuclear track emulsion impregnated with a liquid scintillator provides a very rapid method to determine labelling index and growth fraction of cell suspensions. Low temperature (-20.degree. to -85.degree. C) emulsion exposure for 20 - 60 minutes is sufficient for excellent labelling, thus allowing rapid clinical decision making. Exposure times for research techniques requiring very low energy labelling can be considerably shortened, e.g., from 6 months to 2 weeks or less. This technique therefore has broad applicability to biology and medicine.Type: GrantFiled: October 30, 1975Date of Patent: July 12, 1977Assignee: University Patents, Inc.Inventors: Brian G. M. Durie, Sydney E. Salmon