Patents by Inventor Syed H. Askari
Syed H. Askari has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 9149560Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.Type: GrantFiled: February 10, 2015Date of Patent: October 6, 2015Assignee: Medicus Biosciences LLCInventors: Syed H. Askari, Yeon S. Choi, Paul YuJen Wan
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Publication number: 20150272987Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.Type: ApplicationFiled: June 15, 2015Publication date: October 1, 2015Inventors: Syed H. ASKARI, Yeon S. CHOI, Paul YuJen WAN
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Publication number: 20150273108Abstract: Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.Type: ApplicationFiled: May 27, 2015Publication date: October 1, 2015Inventors: Syed H. ASKARI, Yeon S. CHOI
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Publication number: 20150190544Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.Type: ApplicationFiled: February 10, 2015Publication date: July 9, 2015Inventors: Syed H. ASKARI, Yeon S. CHOI, Paul YuJen WAN
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Patent number: 9072809Abstract: Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.Type: GrantFiled: May 8, 2014Date of Patent: July 7, 2015Assignee: MEDICAL BIOSCIENCES LLCInventors: Syed H. Askari, Yeon S. Choi
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Patent number: 8987339Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.Type: GrantFiled: March 14, 2014Date of Patent: March 24, 2015Assignee: Medicus Biosciences LLCInventors: Syed H. Askari, Yeon S. Choi
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Publication number: 20140302051Abstract: Provided herein are biocompatible hydrogel polymers capable of gelling in vivo comprising a therapeutic agent such as a protein or other biomolecule and kits comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and at least one therapeutic agent. The biocompatible hydrogel polymer is bioabsorbable and releases the therapeutic agent at a target site, avoiding systemic exposure and achieving a controlled delivery.Type: ApplicationFiled: August 9, 2012Publication date: October 9, 2014Applicant: Medicus Biosciences, LLCInventors: Syed H. Askari, Yeon S. Choi, George Horng
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Publication number: 20140271528Abstract: Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Medicus Biosciences LLCInventors: Syed H. ASKARI, Yeon S. CHOI, Paul YuJen WAN
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Publication number: 20140271767Abstract: Provided herein are biocompatible hydrogel polymer matrices, which are prepared from biocompatible pre-formulations. The biocompatible pre-formulations comprise at least one nucleophilic compound, at least one electrophilic compound, and at least one cell. The biocompatible hydrogel polymer matrix is bioabsorbable and releases the cell at a target site, achieving a controlled delivery. The biocompatible hydrogel polymer matrix provides a solid support conducive for cell viability and functionality. The cells may grow on the hydrogel polymer surface of inside the hydrogel polymer matrix.Type: ApplicationFiled: March 14, 2014Publication date: September 18, 2014Applicant: Medicus Biosciences LLCInventors: Syed H. ASKARI, George Horng
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Publication number: 20140248231Abstract: Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.Type: ApplicationFiled: May 8, 2014Publication date: September 4, 2014Applicant: Medicus Biosciences LLCInventors: Syed H. ASKARI, Yeon S. CHOI
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Publication number: 20130116341Abstract: Provided herein are in vivo gelling pharmaceutical pre-formulations forming biocompatible hydrogel polymers that are polymerized in vivo and kits comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally at least one therapeutic agent. The biocompatible hydrogel polymer is bioabsorbable and releases the therapeutic agent at a target site, avoiding systemic exposure.Type: ApplicationFiled: May 6, 2011Publication date: May 9, 2013Applicant: MEDICUS BIOSCIENCES, LLCInventors: Syed H. Askari, George Horng
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Publication number: 20130108711Abstract: Provided herein are methods of treating diseases of the lung in a mammal, including cancer of the lung, mesothelioma, emphysema, and bronchopleural fistula. The methods comprise delivering a biocompatible hydrogel polymer optionally comprising a therapeutic agent directly to a target site using a minimally invasive delivery device, wherein the biocompatible hydrogel polymer gels at the target site.Type: ApplicationFiled: May 6, 2011Publication date: May 2, 2013Applicant: MEDICUS BIOSCIENCES, LLCInventors: Syed H. Askari, George Horng
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Publication number: 20110196060Abstract: Hydrogel compositions prepared from amine components and glycidyl ether components are provided which are biocompatible and suitable for use in vivo due, in part, to their excellent stability.Type: ApplicationFiled: April 19, 2011Publication date: August 11, 2011Applicant: TRIVASCULAR, INC.Inventors: Syed H. Askari, Robert G. Whirley
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Patent number: 6490144Abstract: A chamber 30 for processing a substrate 25 comprises a support 55 comprising a dielectric 60 enveloping an electrode 70. The electrode 70 may be chargeable to electrostatically hold the substrate 25 or may be chargeable to form an energized gas in the chamber 30 to process the substrate 25. A base 130 is below the support 55, and a compliant member 300 is positioned between the support 55 and the base 130. The compliant member 300 may be adapted to alleviate thermal stresses arising from a thermal expansion mismatch between the dielectric 60 and the base 130.Type: GrantFiled: November 29, 1999Date of Patent: December 3, 2002Assignee: Applied Materials, Inc.Inventors: Kadthala R. Narendrnath, Syed H. Askari, Dennis S. Grimard, Surinder S. Bedi, Ananda H. Kumar, Shamouil Shamouilian
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Patent number: 6094334Abstract: An electrostatic chuck 20 for holding a substrate 25 in a process chamber 30 comprises an electrostatic member 115 comprising a polymer 120 covering an electrode 125, the polymer 120 having a receiving surface 135 for receiving the substrate 25. A heater 130 abutting the polymer 120 is provided to heat the substrate 25 during processing of the substrate 25. The heater 130 has a resistance that is sufficiently low to heat the substrate 25 without causing excessive thermal degradation of the polymer 120.Type: GrantFiled: March 2, 1999Date of Patent: July 25, 2000Assignee: Applied Materials, Inc.Inventors: Surinder S. Bedi, Shamouil Shamouilian, Syed H. Askari, Arnold Kholodenko, Jon T. Clinton, Alexander M. Veytser, Liang-Guo Wang, You Wang
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Patent number: 5629360Abstract: Disclosed are optically clear xerogel polymer compositions containing an interpenetrant.Type: GrantFiled: September 22, 1995Date of Patent: May 13, 1997Assignee: Pilkington Barnes Hind, Inc.Inventors: Syed H. Askari, Hermann H. Neidlinger
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Patent number: 5498681Abstract: Disclosed is a polymeric article at least a portion of which is manufactured from a hydrogel material having a hydration level of from between about 45% and 56% by weight, which hydrogel is formed from a xerogel which is a copolymer system that can be solvolyzed and hydrated and during which undergoes a linear expansion of from about -7% to about +7%. The polymeric article is comprised of a copolymer system comprising dichloroacetate ester of glyceryl acrylate, methacrylate and ethacrylate and one or more compatible ethylenically unsaturated monomers without such solvolyzable groups.Type: GrantFiled: February 21, 1995Date of Patent: March 12, 1996Assignee: Pilkington Barnes Hind, Inc.Inventors: Syed H. Askari, Hermann H. Neidlinger, Khushroo Gandhi
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Patent number: 5482981Abstract: Disclosed are optically clear xerogel polymer compositions containing an interpenetrant.Type: GrantFiled: November 9, 1994Date of Patent: January 9, 1996Assignee: Pilkington Barnes Hind, Inc.Inventors: Syed H. Askari, Hermann H. Neidlinger
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Patent number: 5362768Abstract: A polymeric composition suitable for use in ophthalmic devices such as contact lenses, intraocular lenses and other medical and non-medical devices which composition comprises a copolymer that incorporates repeating units containing a solvolyzable group and various desired hydrophilic repeating units in predetermined ratios, which copolymer is mechanically stable and upon hydration the dimensions of polymeric articles which as formed therefrom can be controlled. In particular, the hydrophilic compositions resulting from the invention are user in applications where stresses and distortions of the polymer article due to water absorption etc. must be minimized or, if possible, eliminated.Type: GrantFiled: July 30, 1993Date of Patent: November 8, 1994Assignee: Pilkington Visioncare, Inc.Inventors: Syed H. Askari, Shao C. Jeang, Herman H. Neidlinger