Abstract: The present disclosure provides compositions, devices, systems, methods, and kits for treatment of ophthalmic conditions. The compositions and methods of the present disclosure may include a biodegradable polymer containing an API that could be injected directly in the vitreous humor where it forms a gel and acts as a depo and delivers the drug over an extended desired period of time from 1 month to 1 years or more.

Abstract: Some embodiments include a computer-implemented method that manages immigrant investor visas and/or investments in pursuit of immigrant investor visas including, but not limited to, the United States Citizenship and Immigration Service (“USCIS”) Employment-Based Fifth Preference Immigrant Investor Program (“EB-5 Program” or “EB-5”). In some embodiments, the system includes the ability to accept and process visa applications, accept and process expedited visa applications, authenticate investment source of funds, enable background check processing, enable national security related screening and processing, track visa processing, track legal compliance, track securities law compliance, track national security law compliance, suggest investments, track job creation, track investment performance, and/or monitor investments for fraud.

Abstract: Some embodiments include a computer-implemented system to automate and process the monetization of immigrant visas and/or non-immigrant visas and/or the financial structuring of immigrant visas and/or non-immigrant visas to develop, construct and support the legal and financial structuring of immigrant visas and non-immigrant visas for immigrant and non-immigrant visa financial markets, immigrant and non-immigrant visa financial products, immigrant and non-immigrant visa financial tools, immigrant and non-immigrant visa financial structures, and/or immigrant and non-immigrant visa financial algorithms to support economic development, job creation, direct investment, indirect investment, credit enhancement and/or loan guarantees to support immigrant visa-based and/or non-immigrant visa-based financing, funding and/or investment in multiple industry sectors in the United States and on a global basis.

Abstract: In one embodiment, a device obtains telemetry data regarding a plurality of traffic flows in a network. The device forms a directed graph based on the telemetry data, wherein nodes of the graph represent devices in the network. The device simulates traffic for one or more of the devices by performing random walks starting at a particular node on the directed graph to generate a set of trails, each trail representing a sequence of one or more flows. The device clusters the set of trails to form one or more clusters. The device generates an application fingerprint for an application based on one of the one or more clusters. The device uses the application fingerprint to identify traffic in the network as associated with the application.

Abstract: An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid chamber. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. A surface treatment or coating may be applied to one or more surfaces of the first and second components. The surface treatment is expected to decrease the roughness of the machined surfaces of the boundary surfaces of the first and second components, and thereby reduce the mass of water coalescing at such boundary surfaces. The disclosed surface treatments are also expected to increase the hydrophobicity (i.e., decrease the surface energy) of the corresponding surface(s), thereby decreasing the “wettability” of these surfaces.

Abstract: In one embodiment, a device obtains telemetry data regarding a plurality of traffic flows in a network. The device forms a directed graph based on the telemetry data, wherein nodes of the graph represent devices in the network. The device simulates traffic for one or more of the devices by performing random walks starting at a particular node on the directed graph to generate a set of trails, each trail representing a sequence of one or more flows. The device clusters the set of trails to form one or more clusters. The device generates an application fingerprint for an application based on one of the one or more clusters. The device uses the application fingerprint to identify traffic in the network as associated with the application.

Abstract: An electrical plug or power adapter is described which includes a housing and a plurality of retractable prongs forming at least one retractable prong set. The prongs of each prong set are rotatable simultaneously between a retracted position in which the prongs are positioned within the housing and a deployed position in which the prongs extend out of the housing to be inserted into an electrical outlet. The electrical plug or adapter includes at least one gear-based driving mechanism coupled to a corresponding retractable prong set for driving the simultaneous rotation of the prongs of the prong set. The gear-based driving mechanism includes a driver accessible from the housing for actuation of the corresponding gear-based driving mechanism.

Abstract: Some embodiments include a computer-implemented method that manages immigrant investor visas and/or investments in pursuit of immigrant investor visas including, but not limited to, the United States Citizenship and Immigration Service (“USCIS”) Employment-Based Fifth Preference Immigrant Investor Program (“EB-5 Program” or “EB-5”). In some embodiments, the system includes the ability to accept and process visa applications, accept and process expedited visa applications, authenticate investment source of funds, enable background check processing, enable national security related screening and processing, track visa processing, track legal compliance, track securities law compliance, track national security law compliance, suggest investments, track job creation, track investment performance, and/or monitor investments for fraud.

Abstract: An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid chamber. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. A surface treatment or coating may be applied to one or more surfaces of the first and second components. The surface treatment is expected to decrease the roughness of the machined surfaces of the boundary surfaces of the first and second components, and thereby reduce the mass of water coalescing at such boundary surfaces. The disclosed surface treatments are also expected to increase the hydrophobicity (i.e., decrease the surface energy) of the corresponding surface(s), thereby decreasing the “wettability” of these surfaces.

Abstract: The present disclosure provides compositions, devices, systems, methods, and kits for treatment of nasal conditions. The compositions and methods of the present disclosure may include a biodegradable polymer formed by, for example, a Michael addition reaction between a thiol moiety and an acrylate moiety.

Abstract: An electrical plug or power adapter is described which includes a housing and a plurality of retractable prongs forming at least one retractable prong set. The prongs of each prong set are rotatable simultaneously between a retracted position in which the prongs are positioned within the housing and a deployed position in which the prongs extend out of the housing to be inserted into an electrical outlet. The electrical plug or adapter includes at least one gear-based driving mechanism coupled to a corresponding retractable prong set for driving the simultaneous rotation of the prongs of the prong set. The gear-based driving mechanism includes a driver accessible from the housing for actuation of the corresponding gear-based driving mechanism.

Abstract: A medical device for installing sutures to close an incision in tissue or human skin is disclosed. The suturing device may provide first and second arcuate needles. Once properly positioned, the first and second arcuate needles are driven through the sub-dermal layer, or alternatively through a superficial surface, of two sections of skin to be joined. This is done in arcuate fashion and at identical and symmetrical rates of angular displacement. In so doing, the sections of skin are pushed toward one another thus assuring horizontal and vertical alignment of the two sections of skin. During the driving or retraction process of the first and second arcuate needles, a suture is positioned within both the first and second sections of skin and transformed from a planar or a multi-planar serpentine orientation to a helical orientation.

Abstract: A medical device for installing sutures to close an incision in tissue or human skin is disclosed. The suturing device may provide first and second arcuate needles. Once properly positioned, the first and second arcuate needles are driven through the sub-dermal layer, or alternatively through a superficial surface, of two sections of skin to be joined. This is done in arcuate fashion and at identical and symmetrical rates of angular displacement. In so doing, the sections of skin are pushed toward one another thus assuring horizontal and vertical alignment of the two sections of skin. During the driving or retraction process of the first and second arcuate needles, a suture is positioned within both the first and second sections of skin and transformed from a planar or a multi-planar serpentine orientation to a helical orientation.

Abstract: Compositions, kits, and methods are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. The compositions can include a first reagent including a cleavage-inducing moiety and a first binding agent for a binding site that includes a post-translational modification of a target polypeptide.

Abstract: A medical device for installing sutures to close an incision in tissue or human skin is disclosed. The suturing device may provide first and second arcuate needles. Once properly positioned, the first and second arcuate needles are driven through the sub-dermal layer, or alternatively through a superficial surface, of two sections of skin to be joined. This is done in arcuate fashion and at identical and symmetrical rates of angular displacement. During the driving or retraction process of the first and second arcuate needles, a suture is positioned within both the first and second sections of skin and transformed from a planar or a multi-planar serpentine orientation to a helical orientation. The resulting suturing process is thus much faster than conventional or manual suturing and results in superior wound approximation/alignment that will lead to decreased scarring compared to prior art devices.

Abstract: A composition comprising at least one first allergen, which is a respiratory allergen belonging to a first biological source material group, for use in prophylactic treatment of allergy to at least one second allergen, which is selected from the group consisting of a respiratory and a venomous allergen belonging to a second biological source material group and a food allergen of a food composition, in a subject, wherein the subject has not developed any clinical symptoms of allergy to the first allergen and to the second allergen, and wherein the first and second biological source material groups are not the same.

Abstract: Carbon fiber reinforced plastic parts are advantageously coated with powder coating formulations comprising certain red-shifted hydroxyphenylbenzotriazole ultraviolet light absorbers (UVAs). The benzotriazole UVAs are of formulae (I) or (II) The coated carbon fiber reinforced plastic parts are suitable in aerospace applications, automotive parts and sporting goods.

Abstract: Methods, compositions and kits are disclosed for determining one or more target polypeptides in a sample where the target polypeptides have undergone a post-translational modification. A mixture comprising the sample and a first reagent comprising a cleavage-inducing moiety and a first binding agent for a binding site on a target polypeptide is subjected to conditions under which binding of respective binding moieties occurs. The binding site is the result of post-translational modification activity involving the target polypeptide. The method may be employed to determine the target polypeptide itself. In another embodiment the presence and/or amount of the target polypeptide is related to the presence and/or amount and/or activity of an agent such as an enzyme involved in the post-translational modification of the target polypeptide.

Abstract: The present invention provides an organic-inorganic hybrid chiral sorbent for chiral resolution of various racemic compounds viz. racemic mandelic acid, 2-phenyl propionic acid, diethyl tartrate, 2,2?-dihydroxy-1,1?-binaphthalene (BINOL) and cyano chromene oxide with excellent chiral separation (enantiomeric excess, 99%) in case of mandelic acid under medium pressure column chromatography. These optically pure enantiomers find applications as intermediates in pharmaceutical industries.

Abstract: Carbon fiber reinforced plastic parts are advantageously coated with powder coating formulations comprising certain red-shifted hydroxyphenylbenzotriazole ultraviolet light absorbers (UVAs). The benzotriazole UVAs are of formulae (I) or (II) The coated carbon fiber reinforced plastic parts are suitable in aerospace applications, automotive parts and sporting goods.