Abstract: The present invention relates to pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosucciniroide compounds of formulae (I)-(IV), and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of pyrrolidin-2-one, pyrrolidin-2,5-dione, pyrrolidine and thiosuccinimide compound of the present invention.

Abstract: The present invention relates to substituted 1H-pyrazolo-[3,4-d]pyrimidine-6-amine compounds and methods of synthesizing these compounds. The present invention also relates to pharmaceutical compositions containing substituted 1H-pyrazolo-[3,4-d]pyrimidine-6-amine compounds and methods of treating cell proliferative disorders, such as cancer, by administering these compounds and pharmaceutical compositions to subjects in need thereof.

Abstract: A method for analyzing a target system that includes obtaining a plurality of characteristics from the target system using a characteristics extractor, wherein the plurality of characteristics is associated with a characteristics model, storing each of the plurality of characteristics in a characteristics store using a tracking mechanism, and analyzing the target system by issuing a query to the characteristics store to obtain an analysis result, wherein the query uses tracking information associated with the tracking mechanism.

Abstract: A method for analyzing a target system that includes obtaining a characteristics model, generating at least one selected from the group consisting of a schema, characteristics store API, and a characteristics extractor, using the characteristics model, obtaining a plurality of characteristics from the target system using characteristics extractor, wherein each of the plurality of characteristics is associated with the characteristics model, storing each of the plurality of characteristics in the characteristics store using the schema, and analyzing the target system by issuing at least one query to the characteristics store to obtain an analysis result.

Abstract: A method for analyzing a target system that includes generating a characteristics model using a schema defining a domain, obtaining a plurality of characteristics from the target system using a characteristics extractor, wherein the plurality of characteristics is associated with the characteristics model storing each of the plurality of characteristics in a characteristics store, and analyzing the target system by issuing at least one query to the characteristics store to obtain an analysis result.

Abstract: A method for analyzing a target system that includes obtaining a characteristics model, loading the characteristics model into a meta model, obtaining a plurality of characteristics from the target system using a characteristics extractor, wherein each of the plurality of characteristics is associated with the characteristics model, storing each of the plurality of characteristics obtained from the target system in a characteristics store, and analyzing the target system by issuing at least one query to the characteristics store to obtain an analysis result, wherein the issuing the at least one query comprises verifying the at least one query using the meta model.

Abstract: A system for specifying read/write consistency for an application including an application including at least one transaction, wherein the at least one transaction includes at least one of a plurality of states, at least one of a plurality of transitions, and at least one artifact; and a database operatively connected to the application, wherein the application accesses data associated with the at least one artifact using a read/write consistency specification; wherein the read/write consistency specification specifies at least one selected from the group consisting of a read consistency and a write consistency for the at least one artifact within the transaction.

Abstract: A method for analyzing a target system that includes obtaining a plurality of characteristics from the target system using a characteristics extractor and at least one selected from the group consisting of a software build project associated with the target system and a modified software build project associated with the target system, wherein the plurality of characteristics is associated with a characteristics model, storing each of the plurality of characteristics in a characteristics store, and analyzing the target system by issuing at least one query to the characteristics store to obtain an analysis result.

Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.

Abstract: The present invention provides tetrazole compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the tetrazole compounds. The present invention provides methods of treating a cell proliferative disorder, such as a cancer, by administering to a subject in need thereof a therapeutically effective amount of a compound of the present invention.

Abstract: The present invention relates to quinazolinone compounds, and methods of preparation of these compounds. The present invention also relates to pharmaceutical compositions comprising the quinazolinone compounds.

Abstract: The present invention provides imidazooxazole and imidazothiazole compounds and their synthesis. The compounds of the present invention are capable of inhibiting the activity of RAF kinase, such as B-RAFV600E. The compounds are useful for the treatment of cell proliferative disorders such as cancer.

Abstract: A distributed system having a client and a server includes a state manager interposed between the client and the server. The state manager has a capability to generate a list of object attributes required to represent a state of the distributed system and a capability to cache object attributes so as to be locally accessible by the client. The distributed system further includes a service component interposed between the state manager and the server. The service component has a capability to fetch data from the server based on the list of object attributes.

Abstract: A method for a system having distributed collaborating components includes restricting direct interaction between distributed collaborating components by introducing an application-independent interface between distributed collaborating components and invoking a service from the application-independent interface in order to enable interaction between distributed collaborating components.

Abstract: A method for transparently optimizing data access. The method includes gathering information related to data usage when a system is processing and determining a usage pattern of the system using gathered information.

Abstract: A method for generating a projected graph data structure, including generating a request for the projected graph data structure using a variable usage specification, retrieving a server graph data structure using the request, generating a projected graph data structure representation using the request, the server graph data-structure, and a schema associated with the server graph data-structure, and instantiating the projected graph data-structure using the projected graph data-structure representation.

Abstract: A method for the inhibition of high affinity glycine transporters, compounds that inhibit these transporters; pharmaceutically active compositions comprising such compounds; and the use of such compounds either as above, or in formulations for the control or prevention of disease states in which glycine is involved are disclosed.

Abstract: A method for marking a transaction, comprising defining an application as a plurality of states, wherein each of the plurality of states is associated with at least one transition, specifying a transaction set comprising at least one of the plurality of states, specifying a commit set comprising at least one of a plurality of states, and marking the transaction using a transaction marking procedure, wherein the transaction marking procedure marks the transaction based on the transaction set, the commit set, and at least one of the plurality of transitions.

Abstract: A method for deriving an application specification from an enterprise application including mapping the enterprise application to obtain a plurality of states and a plurality of transitions, monitoring the enterprise application to obtain a list of variable usages for each of the plurality of states, parsing source code of the enterprise application to obtain process logic for each of the plurality of transitions, and deriving the application specification using each of the plurality of states, the plurality of transitions, the list of variable usages for each of the plurality of states, and the process logic for each of a plurality of transitions.

Abstract: A method for merging a first object graph with a second object graph, including packaging the first object graph into an internal representation, wherein the internal representation includes an attribute value and an object identity for each of a plurality of objects in the first object graph, sending the internal representation to a receiver, traversing the internal representation by the receiver, updating an object instance in the second object graph with the attribute value from the internal representation, if the object identity corresponding to the object instance is found in an identity mapping table, creating and populating a new object instance with the attribute value from the internal representation, if the object identity corresponding to the new object instance is not found in the identity mapping table, and linking the new object instance to the second object graph.