Patents by Inventor Syed Zaki Salahuddin

Syed Zaki Salahuddin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Recombinant HIV and modified packaging cells and method for using
    Patent number: 6063374
    Abstract: A recombinant human immunodeficiency virus (rHIV) and recombinant mammalian cell-line (packaging systems) and a method for treating infection of cells by human immuneodeficiency virus HIV. rHIV, such as rHIV-1, comprises of a gene construction which includes a foreign gene. The expression of this gene is activated in human cells in the presence of wild-type HIV. This gene product can cause cell death in the presence of an appropriate drug, e.g. Acyclovir. This gene product is typically a viral thymidine kinase. rHIV is so constructed that it is unable to replicate by itself due to the absence of a regulatory gene that is necessary for its replication, such as tat or rev or both. The recombinant mammalian cell-line packaging system comprises in its genome a recombinant gene construction which typically includes a functional regulatory gene from HIV which is missing from rHIV, such as the tat or rev genes or both.
    Type: Grant
    Filed: November 28, 1995
    Date of Patent: May 16, 2000
    Assignee: Clinical Technologies, Inc.
    Inventors: Syed Zaki Salahuddin, Nickolas Chelyapov
  • Antibodies against human herpesvirus-6(HHV-6) and method of use
    Patent number: 6054283
    Abstract: A new human B lymphotropic virus, also designated human herpesvirus-6, has been isolated. DNA, molecular clones, antigenic viral proteins and antibodies having specificity to the new virus have been prepared. Various utilities of the new virus and products derived therefrom have been described.
    Type: Grant
    Filed: December 23, 1996
    Date of Patent: April 25, 2000
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Syed Zaki Salahuddin, Dharam V. Ablashi, Steven F. Josephs, Carl W. Saxinger, Flossie Wong-Staal, Robert C. Gallo
  • Human herpesvirus-6 (HHV-6) isolation and products
    Patent number: 6018027
    Abstract: A new human B lymphotropic virus, also designated human herpesvirus-6, has been isolated. DNA, molecular clones, antigenic viral proteins and antibodies having specificity to the new virus have been prepared. Various utilities of the new virus and products derived therefrom have been described.
    Type: Grant
    Filed: December 30, 1997
    Date of Patent: January 25, 2000
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Syed Zaki Salahuddin, Dharam V Ablashi, Steven F. Josephs, Carl W. Saxinger, Flossie Wong-Staal, Robert C. Gallo
  • Recombinant HIV and modified packaging cells and method for treating acquired immune deficiency syndrome
    Patent number: 5753490
    Abstract: A recombinant human immunodeficiency virus (rHIV) and recombinant mammalian cell-line (packaging systems) and a method for treating infection of cells by human immuneodeficiency virus HIV. rHIV, such as rHIV-1, comprises of a gene construction which includes a foreign gene. The expression of this gene is activated in human cells in the presence of wild-type HIV. This gene product can cause cell death in the presence of an appropriate drug, e.g. Acyclovir. This gene product is typically a viral thymidine kinase. rHIV is so constructed that it is unable to replicate by itself due to the absence of a regulatory gene that is necessary for its replication, such as tat or rev or both. The recombinant mammalian cell-line packaging system comprises in its genome a recombinant gene construction which typically includes a functional regulatory gene from HIV which is missing from rHIV, such as the tat or rev genes or both.
    Type: Grant
    Filed: November 28, 1995
    Date of Patent: May 19, 1998
    Assignee: Clinical Technologies, Inc.
    Inventors: Syed Zaki Salahuddin, Nickolas Chelyapov