Patents by Inventor Sylvain Daigneault

Sylvain Daigneault has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE PREPARATION OF HYDROXY-SUBSTITUTED ARYL SULFAMIDE COMPOUNDS
    Publication number: 20090156826
    Abstract: The present invention is directed to processes for the preparation of hydroxy-substituted aryl sulfamide derivatives of the formula I or pharmaceutically acceptable salts, stereoisomers or tautomers thereof, which are monoamine reuptake inhibitors wherein the constituent variables are as defined herein.
    Type: Application
    Filed: December 11, 2008
    Publication date: June 18, 2009
    Applicant: Wyeth
    Inventors: Maria Papamichelakis, Jacqueline Francesca Lunetta, Mark Lankau, Luc Richard, Christopher Kendall, Marcelo Cesar Saraiva, Xianghui Wen, Mahmoud Mirmehrabi, Valerie Paquet, Sylvain Daigneault, Puwen Zhang
  • TIGECYCLINE AND METHODS OF PREPARING INTERMEDIATES
    Publication number: 20090099376
    Abstract: Methods of preparing and purifying 9-nitrominocycline and 9-aminominocycline and salts thereof used in the process of making tigecycline, are disclosed. In one embodiment, the invention is directed to a method of preparing the compound of formula 1 or a pharmaceutically acceptable salt thereof, comprising: (a) reacting nitric acid with the compound of formula 2, or a salt thereof, to produce a reaction mixture comprising an intermediate; and (b) further reacting the intermediate to form the compound of formula 1, wherein the intermediate is isolated from the reaction mixture, the method further comprising sparging with an inert gas prior to step (a).
    Type: Application
    Filed: October 15, 2008
    Publication date: April 16, 2009
    Applicant: Wyeth
    Inventors: Michel Bernatchez, Warren Chew, Sylvain Daigneault, Ernest Palus, Mahmoud Mirmehrabi, Luc Bouchard
  • Process for the synthesis of 6-amino-4-(3-chloro-4-fluorophenylamino)-7-ethoxyquinoline-3-carbonitrile
    Publication number: 20080161575
    Abstract: The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.
    Type: Application
    Filed: March 10, 2008
    Publication date: July 3, 2008
    Applicant: Wyeth
    Inventors: Sylvain Daigneault, Ronald Stanley Michalak, Michel Bernatchez
  • Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile
    Patent number: 7365203
    Abstract: The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.
    Type: Grant
    Filed: September 10, 2004
    Date of Patent: April 29, 2008
    Assignee: Wyeth
    Inventors: Sylvain Daigneault, Ronald Stanley Michalak, Michel Bernatchez
  • Process for the synthesis of N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids
    Patent number: 7294740
    Abstract: The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.
    Type: Grant
    Filed: May 18, 2007
    Date of Patent: November 13, 2007
    Assignee: Wyeth
    Inventors: Scott Mason Duncan, Augustine Tobi Osuma, Sylvain Daigneault, Michel Bernatchez
  • Process for the synthesis of N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids
    Publication number: 20070219394
    Abstract: The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.
    Type: Application
    Filed: May 18, 2007
    Publication date: September 20, 2007
    Applicant: Wyeth
    Inventors: Scott Duncan, Augustine Osuma, Sylvain Daigneault, Michel Bernatchez
  • Process for the synthesis of N-nacyl-2-amino-4-alkoxy-5-nitrobenzoic acids
    Patent number: 7227037
    Abstract: The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.
    Type: Grant
    Filed: February 5, 2003
    Date of Patent: June 5, 2007
    Assignee: Wyeth
    Inventors: Scott Mason Duncan, Augustine Tobi Osuma, Sylvain Daigneault, Michel Bernatchez
  • Tigecycline and methods of preparing 9-nitrominocycline
    Publication number: 20070049560
    Abstract: Methods of preparing and purifying tetracyclines, such as tigecycline, are disclosed. Also disclosed are tetracycline compositions, such as tigecycline compositions, prepared by these methods.
    Type: Application
    Filed: May 25, 2006
    Publication date: March 1, 2007
    Inventors: Lalitha Krishnan, Phaik-Eng Sum, Sylvain Daigneault, Michel Bernatchez, Anthony Pilcher, Jeffrey Horne, Adam Tuper, Joseph McCauley, Adam Michaud
  • Methods of purifying tigecycline
    Publication number: 20070049561
    Abstract: Methods of preparing and purifying tetracyclines, such as tigecycline, are disclosed. Also disclosed are tetracycline compositions, such as tigecycline compositions, prepared by these methods.
    Type: Application
    Filed: May 25, 2006
    Publication date: March 1, 2007
    Inventors: Lalitha Krishnan, Phaik-Eng Sum, Sylvain Daigneault, Michel Bernatchez, Anthony Pilcher, Jeffrey Horne, Adam Tuper, Joseph McCauley, Adam Michaud
  • Tigecycline and methods of preparing 9-aminominocycline
    Publication number: 20070049563
    Abstract: Methods of preparing and purifying tetracyclines, such as tigecycline, are disclosed. Also disclosed are tetracycline compositions, such as tigecycline compositions, prepared by these methods.
    Type: Application
    Filed: May 25, 2006
    Publication date: March 1, 2007
    Inventors: Lalitha Krishnan, Phaik-Eng Sum, Sylvain Daigneault, Michel Bernatchez, Anthony Pilcher, Jeffrey Horne, Adam Tuper, Joseph McCauley, Adam Michaud
  • Tigecycline and methods of preparation
    Publication number: 20070049562
    Abstract: Methods of preparing and purifying tetracyclines, such as tigecycline, are disclosed. Also disclosed are tetracycline compositions, such as tigecycline compositions, prepared by these methods.
    Type: Application
    Filed: May 25, 2006
    Publication date: March 1, 2007
    Inventors: Lalitha Krishnan, Phaik-Eng Sum, Sylvain Daigneault, Michel Bernatchez, Anthony Pilcher, Jeffrey Horne, Adam Tuper, Joseph McCauley, Adam Michaud
  • Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
    Patent number: 7126025
    Abstract: This invention provides a compound of Formula (I): wherein S1 and S2 are each independently, hydrogen, alkyl, alkenyl, alkynyl, aralkyl, substituted or unsubstituted aryl, and S1 and S2 together with the nitrogen to which they are attached form a nitrogen containing heteroaryl and a pharmaceutically acceptable salt thereof; a method of preparing the compound of Formula (I), and use of the compound of Formula (I) in the preparation of 3-cyano quinolines.
    Type: Grant
    Filed: January 15, 2004
    Date of Patent: October 24, 2006
    Assignee: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Mason Duncan, Jianxin Ren
  • Amino-chroman compounds and methods for preparing same
    Publication number: 20060205807
    Abstract: The present invention relates to novel amino-chroman compounds, methods of preparing such compounds, and to synthetic intermediates useful in such methods.
    Type: Application
    Filed: February 16, 2006
    Publication date: September 14, 2006
    Applicant: Wyeth
    Inventors: Christoph Dehnhardt, Sylvain Daigneault
  • Process for the synthesis of nacyl-2-amino-4-alkoxy-5-nitrobenzoic acids
    Publication number: 20050085662
    Abstract: The invention claimed herein provides a process to oxidize N-(5-alkoxy-2-methyl-4-nitrophenyl)acetamides to N-acyl-2-amino-4-alkoxy-5-nitrobenzoic acids using potassium permanganate in the presence of magnesium sulfate in aqueous sulfolane or aqueous pyridine.
    Type: Application
    Filed: February 5, 2003
    Publication date: April 21, 2005
    Applicant: Wyeth
    Inventors: Scott Duncan, Augustine Osuma, Sylvain Daigneault, Michel Bernatchez
  • Process for the synthesis of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile
    Publication number: 20050065181
    Abstract: The present invention provides a process for the preparation of 6-amino-4-(3-chloro-4-fluoro-phenylamino)-7-ethoxy-quinoline-3-carbonitrile comprising the steps and products disclosed within this application.
    Type: Application
    Filed: September 10, 2004
    Publication date: March 24, 2005
    Applicant: Wyeth
    Inventors: Sylvain Daigneault, Ronald Michalak, Michel Bernatchez
  • Synthesis of 4-(amino)-2-butenoyl chlorides and their use in the preparation of 3-cyano quinolines
    Publication number: 20040162442
    Abstract: This invention provides a compound of Formula (I): 1
    Type: Application
    Filed: January 15, 2004
    Publication date: August 19, 2004
    Applicant: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Mason Duncan, Jianxin Ren
  • Antineoplastic combinations
    Patent number: RE41084
    Abstract: This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.
    Type: Grant
    Filed: December 22, 2006
    Date of Patent: January 19, 2010
    Assignee: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Duncan, Jiaxen Ren
  • Antineoplastic combinations
    Patent number: RE41253
    Abstract: This invention provides the use of a combination of CCI-779 and EKB-569 in the treatment of neoplasms.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: April 20, 2010
    Assignee: Wyeth
    Inventors: John Leo Considine, Sylvain Daigneault, Warren Chew, Silvio Iera, Scott Duncan, Jiaxin Ren