Patents by Inventor Sylvain GARCIAZ

Sylvain GARCIAZ has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NITROGEN-CONTAINING ANALOGS OF SALINOMYCIN FOR USE IN ACUTE MYELOID LEUKEMIA
    Publication number: 20230293478
    Abstract: The invention relates compound of formula (I), enantiomers, mixture of enantiomers, diastereoisomers and mixture of diastereoisomers thereof: wherein W, X, Y and Z are as defined, for use in the treatment of Acute Myeloid Leukemia (AML).
    Type: Application
    Filed: May 12, 2021
    Publication date: September 21, 2023
    Applicants: Centre National de la Recherche Scientifique (CNRS), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Curie, Peter MacCallum Cancer Institute
    Inventors: Raphaël RODRIGUEZ, Mark DAWSON, Sylvain GARCIAZ, Tatiana CANEQUE COBO
  • METHOD OF TREATMENT AND PRONOSTIC OF ACUTE MYELOID LEUKEMIA
    Publication number: 20220340975
    Abstract: The present invention relates to the treatment of AML. The inventors previously discovered a new epigenetic biomarker in a cohort of CN-AML patients; this consists in a strong enrichment in the H3K27me3 histone mark located on a 70 Kb part of the major histone cluster 1 (HIST1) that separates patients into two distinguishable groups defined as H3K27me3HIST1low and H3K27me3HIST1high. Patients harboring the H3K27me3 HIST1 epigenetic mark had a better event free survival. This first observation suggests that H3K27me3HIST1high patients may develop a less aggressive disease. Molecular characterisation of H3K27me3HIST1high patients showed that the linker histone H1d, but not the other histone H1 subtypes, was down-regulated in the H3K27me3 HIST1high group of patients. H1d knockdown primed ATRA differentiation, as assessed on CD11b/CD11c markers, morphological and gene expression analyses.
    Type: Application
    Filed: September 4, 2020
    Publication date: October 27, 2022
    Inventors: Norbert VEY, Sylvain GARCIAZ, Estelle DUPREZ, Dasi-Lia N'GUYEN