Abstract: A method for manufacturing a part from a first ceramic or from carbon, consolidated by a second ceramic, having a determined geometry, that involves carrying out the following sequence of steps: a) manufacturing a preform made from an organic polymer; b) impregnating the preform made from an organic polymer with a resin that is a precursor of the first ceramic or a resin that is a precursor of carbon; c) crosslinking and/or polymerising, then pyrolysing the resin that is a precursor of the first ceramic or the resin that is a precursor of carbon; to obtain a part made from a first ceramic or from carbon having the same geometry as the part to be manufactured; e) depositing the second ceramic on the part made from a first ceramic or from carbon by means of a chemical vapour deposition or CVD process or a chemical vapour infiltration or CVI process.

Abstract: A method for manufacturing a part from a first ceramic or from carbon, consolidated by a second ceramic, having a determined geometry, that involves carrying out the following sequence of steps: a) manufacturing a preform made from an organic polymer; b) impregnating the preform made from an organic polymer with a resin that is a precursor of the first ceramic or a resin that is a precursor of carbon; c) crosslinking and/or polymerising, then pyrolysing the resin that is a precursor of the first ceramic or the resin that is a precursor of carbon; to obtain a part made from a first ceramic or from carbon having the same geometry as the part to be manufactured; e) depositing the second ceramic on the part made from a first ceramic or from carbon by means of a chemical vapour deposition or CVD process or a chemical vapour infiltration or CVI process.

Abstract: A method of fabricating a friction part out of composite material, the method including densifying a carbon yarn fiber preform with a matrix including at least pyrolytic carbon and a ZrOxCy phase, where 1?x?2 and 0?y?1, the matrix being formed by film-boiling or by chemical vapor infiltration from a first precursor for pyrolytic carbon and a second precursor that includes zirconium, the second precursor being a zirconium complex including an alcoxy or carboxylate ligand bonded to zirconium.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

Abstract: A method of fabricating a friction part out of composite material, the method including densifying a carbon yarn fiber preform with a matrix including at least pyrolytic carbon and a ZrOxCy phase, where 1?x?2 and 0?y?1, the matrix being formed by film-boiling or by chemical vapor infiltration from a first precursor for pyrolytic carbon and a second precursor that includes zirconium, the second precursor being a zirconium complex including an alcoxy or carboxylate ligand bonded to zirconium.

Abstract: A compound of formula I, (I) or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer.

Abstract: A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

Abstract: A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.

Abstract: A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.

Abstract: The invention relates to compounds of formula I, or a pharmaceutically-acceptable salt thereof. The present invention also relates to pharmaceutical formulations comprising these compounds, and to their use as medicaments for the treatment of disorders where modulation of DCTPP (deoxycytidine triphosphate pyrophosphatase 1) activity exerts a therapeutic effect.

Abstract: A compound of formula I, or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.

Abstract: A compound of formula (I), or a pharmaceutically acceptable salt thereof, for use in the treatment of autoimmune diseases and inflammatory conditions.

Abstract: A compound of formula I, (I) or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer.

Abstract: A compound of formula (I), or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.

Abstract: A part made of ceramic matrix composite material has fiber reinforcement of carbon or ceramic fibers and a majority-ceramic sequenced matrix having first matrix layers made of crack-deflector material alternating with second matrix layers made of ceramic material. An interphase coating is interposed between the fibers and the matrix, and the interphase coating adheres to the fibers and to the matrix, and is formed of at least one sequence constituted by a first elementary layer made of carbon, possibly doped with boron, surmounted by a second elementary layer made of ceramic. The outer elementary interphase layer of the coating is a ceramic layer having an outer surface formed by ceramic grains of size lying essentially in the range 20 nm to 200 nm, with the presence of grains of size greater than 50 nm conferring roughness on the outer surface ensuring mechanical attachment with the adjacent matrix phase.

Abstract: A method of densifying a porous substrate with a matrix, includes subdividing the pores present in the porous substrate so as to form in the substrate a network of micropores, the subdividing being performed with a filler composition comprising at least one carbon-containing phase or carbide-containing phase that is accessible via the network of micropores; and infiltrating the network of micropores formed by the filler material by reactive chemical vapor infiltration, the infiltration being performed with a reactive gas composition that does not contain carbon and that includes at least one element suitable for reacting with the carbon of the filler composition in order to form a carbide.

Abstract: A compound of formula (I), or a pharmaceutically-acceptable salt thereof. The compound is useful in the treatment of cancer or other diseases that may benefit from inhibition of MTH1.

Abstract: A part made of ceramic matrix composite material has fiber reinforcement of carbon or ceramic fibers and a majority-ceramic sequenced matrix having first matrix layers made of crack-deflector material alternating with second matrix layers made of ceramic material. An interphase coating is interposed between the fibers and the matrix, and the interphase coating adheres to the fibers and to the matrix, and is formed of at least one sequence constituted by a first elementary layer made of carbon, possibly doped with boron, surmounted by a second elementary layer made of ceramic. The outer elementary interphase layer of the coating is a ceramic layer having an outer surface formed by ceramic grains of size lying essentially in the range 20 nm to 200 nm, with the presence of grains of size greater than 50 nm conferring roughness on the outer surface ensuring mechanical attachment with the adjacent matrix phase.