Patents by Inventor Sylvain Juge
Sylvain Juge has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20210238209Abstract: Disclosed is an oleic acid derivative including a hydrophobic part C17H33 linked to a particular polar head part “A”, especially for use as a medicament, for instance, for the treatment of a disorder caused by the GPR120 receptor and/or the CD36 receptor, including administering to a subject in need thereof a therapeutically effective amount of the oleic acid derivative or of the pharmaceutical composition. Also disclosed is the use of the oleic acid derivative as a food composition.Type: ApplicationFiled: May 27, 2019Publication date: August 5, 2021Inventors: Naim KHAN, Sylvain JUGE, Aziz HICHAMI, Jérôme BAYARDON, Floriane MANGIN, Amira KHAN
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Publication number: 20210155640Abstract: Disclosed is a linoleic acid derivative of Formula (I) below including a hydrophobic part C17H31 linked to a polar head part “A”: wherein the polar head part A is selected from A1 to A4 below: or a pharmaceutically/food quality acceptable salt thereof.Type: ApplicationFiled: May 27, 2019Publication date: May 27, 2021Inventors: Naim KHAN, Sylvain JUGE, Aziz HICHAMI, Jérôme BAYARDON, Marie-Laure LOUILLAT-HABERMEYER, Baptiste RUGERI
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Publication number: 20200407381Abstract: In the field of organic phosphorus chemistry, especially the chemistry of bulky organophosphorus compounds, a process for the synthesis of compound of formula (I). This process is especially useful to obtain chiral bulky phosphorus compounds. The present invention also relates to compounds of formula (VII), (VIII), (IX) and (X) and their processes of manufacturing starting from a compound of formula (I).Type: ApplicationFiled: March 20, 2019Publication date: December 31, 2020Applicant: UNIVERSITÉ DE BOURGOGNEInventors: Jérôme BAYARDON, Antonin JAILLET, Sylvain JUGÉ
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Patent number: 9707553Abstract: P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes comprising compounds (I) as ligands are also described. The compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Type: GrantFiled: October 6, 2015Date of Patent: July 18, 2017Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNE, UNIVERSITE DE STRASBOURG, SYNTHELOR SASInventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Hugo Laureano, Jean-Christophe Henry, Frederic Leroux, Francoise Colobert
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Publication number: 20160023199Abstract: Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Type: ApplicationFiled: October 6, 2015Publication date: January 28, 2016Inventors: Sylvain JUGE, Jerome BAYARDON, Emmanuelle REMOND, Hugo LAUREANO, Jean-Christophe HENRY, Frederic LEROUX, Francoise COLOBERT
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Patent number: 9242925Abstract: The ?,?-unsaturated ?-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.Type: GrantFiled: August 28, 2012Date of Patent: January 26, 2016Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNEInventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Marie-Joelle Ondel-Eymin
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Patent number: 9186661Abstract: Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Type: GrantFiled: July 10, 2012Date of Patent: November 17, 2015Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE DE BOURGOGNE, UNIVERSITE DE STRASBOURG, SYNTHELOR SASInventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Hugo Laureano, Jean-Christophe Henry, Frederic Leroux, Francoise Colobert
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Publication number: 20140364339Abstract: The ?,?-unsaturated ?-amino acids of general formula (I). Also, a versatile process for the stereospecific synthesis of said compounds of formula (I), involving a Wittig reaction. Further, intermediate products of general formulae (II) and (III), as shown below, which are involved in the synthesis of compounds (I). Compounds of general formula (I) may be useful as therapeutic substances, or as reagents or intermediates for fine chemistry.Type: ApplicationFiled: August 28, 2012Publication date: December 11, 2014Inventors: Sylvain Jugé, Jérôme Bayardon, Emmanuelle Remond, Marie-Joëlle Ondel-Eymin
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Publication number: 20140142325Abstract: Novel P-chirogenic organophosphorus compounds of general formula (I), a process for the synthesis of the compounds of formula (I), and intermediate products of general formulae (II), (III) and (IV), as shown below, are involved in the synthesis of compounds (I). Metal complexes including compounds (I) as ligands are also described. The novel compounds and complexes are useful in asymmetric catalysis by transition metal complexes or organocatalysis, especially for asymmetric hydrogenation or allylation. Compounds of general formula (I) may be useful as agrochemical and therapeutic substances, or as reagents or intermediates for fine chemistry.Type: ApplicationFiled: July 10, 2012Publication date: May 22, 2014Applicant: Centre National de la Recherche Scientifique(CNRS)Inventors: Sylvain Juge, Jerome Bayardon, Emmanuelle Remond, Hugo Laureano, Jean-Christophe Henry, Frederic Leroux, Francoise Colobert
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Patent number: 5614641Abstract: The present invention concerns a process for enantioselective catalytic hydrogenation of the ketone C.dbd.O double bond to a secondary alcohol function, said process using a neutral ruthenium complex as the catalyst and a compound containing a C.dbd.O group as the substrate to be hydrogenated, characterised in that it comprises hydrogenation of the substrate using a diallyl (diphosphino) ruthenium compound with formula ##STR1## where al preferably represents CH.sub.2 CH.dbd.CH.sub.2 or CH.sub.2 C(CH.sub.3).dbd.CH.sub.2,Q represents a hydrocarbon bridge containing at least two catenary carbon atoms and which can contain one to four catenary heteroatoms selected from O, S, N and Si,R.sup.1 to R.sup.4 may be identical or different and each represents a C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.7 cycloalkyl or C.sub.6 -C.sub.12 aryl group.Type: GrantFiled: March 9, 1995Date of Patent: March 25, 1997Assignee: Elf AquitaineInventors: Jean-Pierre Genet, Sylvain Juge, Jean-Alex Laffitte, Catherine Pinel, Serge Mallart
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Patent number: 5434285Abstract: The present invention relates, by way of novel industrial products, to the phosphinite-borane compounds of the general formula ##STR1## in which R.sup.1 and R.sup.2, which are identical or different, are each a C.sub.1 -C.sub.18 -alkyl group, a C.sub.5 -C.sub.18 -cycloalkyl group, a C.sub.7 -C.sub.18 -aralkyl group or a C.sub.6 -C.sub.14 -aryl group, it being possible for each of these groups to carry functional groups, and F is a silicon containing bridging group.These products are useful in the syntheses of chiral compounds.Type: GrantFiled: October 7, 1993Date of Patent: July 18, 1995Assignee: Societe Nationale Elf AquitaineInventors: Jean A. Laffitte, Sylvain Juge, Jean P. Genet, Massoud Stephan
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Patent number: 5426216Abstract: The present invention relates to a process for the hydrogenation of ethylenically unsaturated organic compounds. This process is carried out in a homogeneous medium containing a hydrogenation catalyst formed by a complex of ruthenium with a phosphine, which comprises two allylic groups as ligands on the Ru.Type: GrantFiled: August 12, 1993Date of Patent: June 20, 1995Assignee: Society Nationale Elf AquitaineInventors: Jean-Pierre Genet, Sylvain Juge, Jean A. Laffitte, Catherine Pinel, Sergio Mallart
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Patent number: 5324850Abstract: Method for the preparation of a chiral catalyst, comprised of an organic complex of ruthenium and phosphorus, consisting in heating a complex of ruthenium with a phosphine, within an organic liquid, inert in relation to substances in presence, the heated complex being based on a diene and an allylic compound; the product obtained following the heating is subjected to the action of an acid in an organic solvent.Type: GrantFiled: February 21, 1992Date of Patent: June 28, 1994Assignee: Societe Nationale Elf AquitaineInventors: Sylvain Juge, Jean-Pierre Genet, Sergio Mallart
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Patent number: 5264602Abstract: This invention is concerned with new chiral diphosphinite-borane compound of the formula ##STR1## wherein R.sup.1 and R.sup.2, identical or different, represent each a C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.18 cycloalkyl, C.sub.7 -C.sub.18 aralkyl or C.sub.6 -C.sub.14 aryl group which can bear functional groups,R.sup.3 represents a C.sub.1 -C.sub.18 alkyl, C.sub.5 -C.sub.18 cycloalkyl, C.sub.7 -C.sub.18 aralkyl, C.sub.6 -C.sub.14 aryl, C.sub.1 -C.sub.18 alkoxy, C.sub.5 -C.sub.18 cycloalkyloxy, C.sub.7 -C.sub.18 aralkyloxy or C.sub.6 -C.sub.14 aryloxy group,Z represents a bridge linking the two phosphinite P atoms, said bridge being (i) a hydrocarbon chain having from 1 to 12 catenary C atoms or (ii) a heterohydrocarbon chain comprising from 1 to 12 catenary C atoms and at least one catenary heteroatom selected from the group consisting of O, S, Si, P and N.These chiral compounds are useful in the manufacture of chiral diphosphine compounds.Type: GrantFiled: January 9, 1992Date of Patent: November 23, 1993Assignee: Societe Nationale Elf AquitaineInventors: Sylvain Juge, Jean-Pierre Genet, Jean-Alex Laffitte, Massoud Stephan
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Patent number: 5166389Abstract: New chemical product, constituted by an organic phosphorus compound of the structure ##STR1## where Q is an N or O atom, T is an alkylene or arylene, possibly carrying substituents, or not existing, while R.sup.1 to R.sup.7, the same or different, are H or aliphatic, cycloaliphatic and/or arylic hydrocarbon radicals, possibly substituted, R.sup.3 not existing when Q is oxygen. This product is used as an intermediate in the preparation of different derivatives of phosphinous acid.Type: GrantFiled: July 29, 1991Date of Patent: November 24, 1992Assignee: Societe Nationale Elf AquitaineInventors: Sylvain Juge, Jean-Pierre Genet
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Patent number: 5084582Abstract: The invention relates to a method of oxidizing epoxyalcohols, in a medium containing an organic solvent and water, by means of a solid oxidizing compound, in the presence of a catalyst based on a ruthenium salt. The proportion of water relative to that of organic solvent is sufficiently small for at least the major part of the oxidizing compound to remain in the solid state in the reaction medium, which is heterogeneous.Type: GrantFiled: January 18, 1991Date of Patent: January 28, 1992Assignee: Societe Nationale Elf AquitaineInventors: Jean-Pierre Genet, Dominique Pons, Sylvain Juge
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Patent number: 5068425Abstract: Phosphinamides are prepared by the action of an organic halide on an oxazaphospholidine. Depending upon the configuration desired for the stereoisomer to be obtained, an oxazaphospholidine is utilized which has been derived from a (+) or (-) optically-active amino-alcohol. These phosphinamides are useful for the preparation of phosphinates, in particular optically-active phosphinates of known absolute configuration; for this, the phosphinamide is subjected to alcoholysis.Type: GrantFiled: October 17, 1990Date of Patent: November 26, 1991Assignee: Societe Nationale Elf AquitaineInventor: Sylvain Juge
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Patent number: 5043465Abstract: New organic phosphorus compounds, comprised of hetero-phosphacycloalkanes whose phosphorus atom forms a complex with a borane. They can be prepared by the action of a borane on a hetero-phosphacycloalkane, within a solvent, at temperatures ranging from -20.degree. to +60.degree. C. Their transformation into other derivatives, phosphinites or phosphines in particular, can be carried out without any modification in the chirality of the initial complex. An especially useful application is their conversion into highly optically active phosphines, used in particular as catalysts in various reactions.Type: GrantFiled: December 28, 1989Date of Patent: August 27, 1991Assignee: Societe Nationale Elf AquitaineInventors: Sylvain Juge, Jean-Pierre Genet
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Patent number: 4983768Abstract: Phosphinamides are prepared by the action of an organic halide on an oxazaphospholidine. Depending upon the configuration desired for the stereoisomer to be obtained, an oxazaphospholidine is utilized which has been derived from a (+) or (-) optically-active amino-alcohol. These phosphinamides are useful for the preparation of phosphinates, in particular optically-active phosphinates of known absolute configuration; for this, the phosphinamide is subjected to alcoholysis.Type: GrantFiled: July 15, 1985Date of Patent: January 8, 1991Assignee: Societe Nationale Elf AquitaineInventor: Sylvain Juge
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Patent number: 4952740Abstract: New cyclic phosphonites, in which one of the oxygen atoms of the ring can be replaced by an atom of sulphur or nitrogen; the molecule has an asymmetry due to at least two carbon atoms, one or more nitrogen and/or oxygen atoms or several of these elements together.Preparation of these phosphonites by the reaction of a dihalogeno-phosphine with a compound having two active H atoms, in the presence of a hydracid acceptor.Application of the new phosphonites to the production of the corresponding phosphinates and phosphine oxides.Type: GrantFiled: September 12, 1989Date of Patent: August 28, 1990Assignee: Societe Nationale Elf AquitaineInventors: Sylvain Juge, Yvonne Legras