Patents by Inventor Sylvain Lejeune

Sylvain Lejeune has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for treating vaso-occlusive crisis using non-modified annexin V
    Patent number: 10139420
    Abstract: The present invention relates to methods for determining the risk of severe complications in hemolytic diseases. The present invention relates to a method for determining whether a patient suffering from sickle cell disease is at risk for a vaso-occlusive crisis comprising the steps consisting of i) determining the level of cell microparticles in a blood sample obtained from said patient and ii) determining the level of heme and/or hemoglobin contained in said cell microparticles. The present invention also relates to a method for a method the severe complication in hemolytic diseases comprising the steps consisting of i) determining the level of cell microparticles in a blood sample obtained from said patient and ii) determining the level of heme and/or hemoglobin contained in said cell microparticles.
    Type: Grant
    Filed: March 9, 2012
    Date of Patent: November 27, 2018
    Assignees: ISNERM (Institut National de la Sante et de la Recherche Medicale), Assistance Publique—Hopitaux de Paris
    Inventors: Olivier Blanc-Brude, Pierre-Louis Tharaux, Chantal Boulanger, Sylvain Lejeune, Francois Lionnet
  • METHODS AND PHARMACEUTICAL COMPOSITIONS FOR TREATING VASO-OCCLUSIVE CRISIS
    Publication number: 20170049862
    Abstract: The present invention relates to methods and pharmaceutical compositions for treating vaso-occlusive crises. In particular, the present invention relates to a method of treating a vaso-occlusive crisis in a subject in need thereof comprising administering to the subject a therapeutically effective amount of agent capable of degrading, destabilizing or depleting the blood-borne extracellular DNA from the blood of the subject.
    Type: Application
    Filed: April 29, 2015
    Publication date: February 23, 2017
    Applicants: Inserm (Institut National de la Sante et de la Recherche Medicale), Universite Paris Descartes, Assistance Publique-Hopitaux de Paris (APHP)
    Inventors: Olivier BLANC-BRUDE, Sylvain LEJEUNE
  • METHODS TO CHARACTERIZE PATIENTS SUFFERING FROM HEMOLYSIS
    Publication number: 20140044735
    Abstract: The present invention relates to methods for determining the risk of severe complications in hemolytic diseases. The present invention relates to a method for determining whether a patient suffering from sickle cell disease is at risk for a vaso-occlusive crisis comprising the steps consisting of i) determining the level of cell microparticles in a blood sample obtained from said patient and ii) determining the level of heme and/or hemoglobin contained in said cell microparticles. The present invention also relates to a method for a method the severe complication in hemolytic diseases comprising the steps consisting of i) determining the level of cell microparticles in a blood sample obtained from said patient and ii) determining the level of heme and/or hemoglobin contained in said cell microparticles.
    Type: Application
    Filed: March 9, 2012
    Publication date: February 13, 2014
    Inventors: Olivier Blanc-Brude, Pierre-Louis Tharaux, Chantal Boulanger, Sylvain Lejeune, Francois Lionnet