Patents by Inventor Sylvain Orenga

Sylvain Orenga has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11414403
    Abstract: A new compound exhibiting particularly advantageous antibacterial properties, and having the structural formula: L-pyroglutamyl-L-1-aminoethyltetrazole (or N-(1-(1H-tetrazol-5-yl)ethyl)-5-oxopyrrolidine-2-carboxamide). Also, the use of this compound in microbiological culture methods and media intended for the detection, identification, enrichment, counting and/or isolation of target microorganisms that may be encountered in samples taken for clinical diagnosis or microbiological health control purposes.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: August 16, 2022
    Assignee: BIOMERIEUX
    Inventors: Rosaleen Anderson, Mark Gray, Laszlo Kondacs, Sylvain Orenga, John Perry
  • Publication number: 20210363563
    Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.
    Type: Application
    Filed: August 3, 2021
    Publication date: November 25, 2021
    Applicant: BIOMERIEUX
    Inventors: Sylvain ORENGA, Céline ROGER-DALBERT, John PERRY, Vanessa CHANTEPERDRIX, Gilles ZAMBARDI, Nathalie BAL
  • Patent number: 11111518
    Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.
    Type: Grant
    Filed: November 8, 2019
    Date of Patent: September 7, 2021
    Assignee: BIOMERIEUX
    Inventors: Sylvain Orenga, Céline Roger-Dalbert, John Perry, Vanessa Chanteperdrix, Gilles Zambardi, Nathalie Bal
  • Patent number: 11001873
    Abstract: A microorganism detection medium, said detection being based on showing the presence of a microbial enzyme activity chosen from esterase and/or osidase and/or peptidase and/or sulfatase and/or phosphatase activities of microorganisms, preferably said microbial enzyme activity being an esterase activity, said medium comprising: at least one chromogenic and/or fluorogenic substrate specific to the enzyme activity sought, preferably specific to an esterase activity, at least one alkyl(thio)glycoside, at least one solvent (S).
    Type: Grant
    Filed: August 28, 2018
    Date of Patent: May 11, 2021
    Assignee: BIOMERIEUX
    Inventors: Marie Cellier, Sylvain Orenga, John Perry
  • Patent number: 10808275
    Abstract: Use of at least one chromogenic and/or fluorogenic phosphatase substrate for the detection and/or enumeration of enterobacteria in a sample likely to contain them, such as a food sample.
    Type: Grant
    Filed: April 1, 2014
    Date of Patent: October 20, 2020
    Assignee: BIOMÉRIEUX
    Inventors: Marie Cellier, Marie-Pierre Bourguignon, Diane Halimi, Sylvain Orenga
  • Publication number: 20200277281
    Abstract: A new compound exhibiting particularly advantageous antibacterial properties, and having the structural formula: L-pyroglutamyl-L-1-aminoethyltetrazole (or N-(1-(1H-tetrazol-5-yl)ethyl)-5-oxopyrrolidine-2-carboxamide). Also, the use of this compound in microbiological culture methods and media intended for the detection, identification, enrichment, counting and/or isolation of target microorganisms that may be encountered in samples taken for clinical diagnosis or microbiological health control purposes.
    Type: Application
    Filed: September 24, 2018
    Publication date: September 3, 2020
    Applicant: BIOMÉRIEUX
    Inventors: Rosaleen ANDERSON, Mark GRAY, Laszlo KONDACS, Sylvain ORENGA, John PERRY
  • Patent number: 10597693
    Abstract: A process for the enrichment and selective culture of mycobacteria contained in a biological sample, wherein all or part of the sample is inoculated in/on a culture medium including a nutritive component suitable for the development and growth of mycobacteria, wherein the culture medium includes, as selective agents, at least 9-chloro-9-(4?-diethylamino)phenyl-9,10-dihydro-10-phenylacridine hydrochloride (or C-390) and an agent capable of inhibiting Pseudomonas aeruginosa bacteria. The invention also relates to a culture medium suitable for implementing this process for the enrichment and selective culture of mycobacteria.
    Type: Grant
    Filed: February 4, 2016
    Date of Patent: March 24, 2020
    Assignee: BIOMERIEUX
    Inventors: Sylvain Orenga, Audrey Perry, John Perry, Clair Preece
  • Publication number: 20200071742
    Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.
    Type: Application
    Filed: November 8, 2019
    Publication date: March 5, 2020
    Applicant: BIOMERIEUX
    Inventors: Sylvain ORENGA, Céline ROGER-DALBERT, John PERRY, Vanessa CHANTEPERDRIX, Gilles ZAMBARDI, Nathalie BAL
  • Patent number: 10494658
    Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.
    Type: Grant
    Filed: November 7, 2016
    Date of Patent: December 3, 2019
    Assignee: BIOMERIEUX SA
    Inventors: Sylvain Orenga, Céline Roger-Dalbert, John Perry, Vanessa Chanteperdrix, Gilles Zambardi, Nathalie Bal
  • Publication number: 20190136291
    Abstract: A microorganism detection medium, said detection being based on showing the presence of a microbial enzyme activity chosen from esterase and/or osidase and/or peptidase and/or sulfatase and/or phosphatase activities of microorganisms, preferably said microbial enzyme activity being an esterase activity, said medium comprising: at least one chromogenic and/or fluorogenic substrate specific to the enzyme activity sought, preferably specific to an esterase activity, at least one alkyl(thio)glycoside, at least one solvent (S).
    Type: Application
    Filed: August 28, 2018
    Publication date: May 9, 2019
    Inventors: MARIE CELLIER, SYLVAIN ORENGA, JOHN PERRY
  • Patent number: 10077464
    Abstract: A microorganism detection medium, said detection being based on showing the presence of a microbial enzyme activity chosen from esterase and/or osidase and/or peptidase and/or sulfatase and/or phosphatase activities of microorganisms, preferably said microbial enzyme activity being an esterase activity, said medium comprising: at least one chromogenic and/or fluorogenic substrate specific to the enzyme activity sought, preferably specific to an esterase activity, at least one alkyl(thio)glycoside, at least one solvent (S).
    Type: Grant
    Filed: December 24, 2013
    Date of Patent: September 18, 2018
    Assignee: Biomerieux
    Inventors: Marie Cellier, Sylvain Orenga, John Perry
  • Patent number: 9969758
    Abstract: An antimicrobial compound, as well as the salts, derivatives and analogs thereof, said compound being represented by the general formula (I): wherein R1 represents a peptide part P1 or a peptide part P2.
    Type: Grant
    Filed: March 23, 2015
    Date of Patent: May 15, 2018
    Assignee: Biomerieux
    Inventors: Rosaleen Joy Anderson, Alexandre F. Bedernjak, Marie Cellier, Keng Tiong Ng, Sylvain Orenga, John D. Perry, Linda Varadi
  • Publication number: 20180030500
    Abstract: A process for the enrichment and selective culture of mycobacteria contained in a biological sample, wherein all or part of the sample is inoculated in/on a culture medium including a nutritive component suitable for the development and growth of mycobacteria, wherein the culture medium includes, as selective agents, at least 9-chloro-9-(4?-diethylamino)phenyl-9,10-dihydro-10-phenylacridine hydrochloride (or C-390) and an agent capable of inhibiting Pseudomonas aeruginosa bacteria. The invention also relates to a culture medium suitable for implementing this process for the enrichment and selective culture of mycobacteria.
    Type: Application
    Filed: February 4, 2016
    Publication date: February 1, 2018
    Applicant: BIOMÉRIEUX
    Inventors: Sylvain ORENGA, Audrey PERRY, John PERRY, Clair PREECE
  • Publication number: 20170158720
    Abstract: An antimicrobial compound, as well as the salts, derivatives and analogues thereof, said compound being represented by the general formula (I): wherein R1 represents a peptide part P1 or a peptide part P2.
    Type: Application
    Filed: March 23, 2015
    Publication date: June 8, 2017
    Inventors: Rosaleen Joy ANDERSON, Alexandre F. BEDERNJAK, Marie CELLIER, Keng Tiong NG, Sylvain ORENGA, John D. PERRY, Linda VARADI
  • Publication number: 20170058317
    Abstract: A method for distinguishing among a first group of microorganisms belonging to a first taxon of Gram negative bacteria, the first group of bacteria exhibiting a mechanism of resistance to a treatment; a second group of microorganisms belonging to a second taxon of Gram negative bacteria, the second taxon of bacteria being different than said first taxon, and exhibiting a mechanism of resistance to a treatment identical to the mechanism of the first group; and a third group of Gram negative bacteria that is not resistant to the treatment.
    Type: Application
    Filed: November 7, 2016
    Publication date: March 2, 2017
    Applicant: Biomerieux
    Inventors: Sylvain Orenga, Céline Roger-Dalbert, John Perry, Vanessa Chanteperdrix, Gilles Zambardi, Nathalie Bal
  • Patent number: 9528990
    Abstract: The invention relates to fluorescent/fluorogenic probes of formula (I?) or (II?): wherein Z is chosen between: —NH2 and —OH, or in the fluorescence quencher group consisting of: —NO2; —N?N—R1; R1 being any organic group that does not obscure the corresponding azo bond; —NHCO-Pept.; Pept. being a peptide residue or any organic group that does not obscure the corresponding amide bond; —O-Glyc.; Glyc. being a oligoglycoside residue that does not obscure the corresponding glycosidic bond; —O—C(O)—R2; —O—P(O)(OR2)(OR2?) and —O—S(O)2—R2; R2 and R2? being independently a hydrogen atom or an organic group that does not obscure the corresponding ester bond; and ?Ra, Rb, Rc, Rd and Re being independently a hydrogen atom or any organic group that does not obscure the corresponding arylether bond so as not to prevent its possible cleavage by a myeloperoxidase activity.
    Type: Grant
    Filed: May 22, 2015
    Date of Patent: December 27, 2016
    Assignees: BIOMERIEUX S.A., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE ROUEN
    Inventors: Sylvain Orenga, Valérie Chalansonnet, Arnaud Chevalier, Pierre-Yves Renard, Anthony Romieu, Benoit Roubinet
  • Publication number: 20160146814
    Abstract: The invention relates to fluorescent/fluorogenic probes of formula (I?) or (II?): wherein Z is chosen between: —NH2 and —OH, or in the fluorescence quencher group consisting of: —NO2; —N?N—R1; R1 being any organic group that does not obscure the corresponding azo bond; —NHCO-Pept.; Pept. being a peptide residue or any organic group that does not obscure the corresponding amide bond; —O-Glyc.; Glyc. being a oligoglycoside residue that does not obscure the corresponding glycosidic bond; —O—C(O)—R2; —O—P(O)(OR2)(OR2?) and —O—S(O)2—R2; R2 and R2? being independently a hydrogen atom or an organic group that does not obscure the corresponding ester bond; and Ra, Rb, Rc, Rd and Re being independently a hydrogen atom or any organic group that does not obscure the corresponding arylether bond so as not to prevent its possible cleavage by a myeloperoxidase activity.
    Type: Application
    Filed: May 22, 2015
    Publication date: May 26, 2016
    Inventors: Sylvain Orenga, Valérie Chalansonnet, Arnaud Chevalier, Pierre-Yves Renard, Anthony Romieu, Benoît Roubinet
  • Patent number: 9322048
    Abstract: The present invention relates to the field of microbiological testing of food. It relates to a kit comprising a reaction medium containing at least one inhibitor of Gram-negative bacteria and a fluorescent substrate specific for PC-PLC. It further relates to a diagnostic kit for identifying bacteria of the Bacillus cereus group comprising a container of a selective or nonselective reaction medium with a pH between 6.8 and 8.0, the medium comprising at least one inhibitor of Gram-negative bacteria and a fluorescent phosphatidylcholine phospholipase C (PC-PLC) substrate.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: April 26, 2016
    Assignee: bioMerieux, S.A.
    Inventors: Marie Cellier, John Mills, David Mosticone, Sylvain Orenga, Antoine Vimont
  • Publication number: 20160046976
    Abstract: Use of at least one chromogenic and/or fluorogenic phosphatase substrate for the detection and/or enumeration of enterobacteria in a sample likely to contain them, such as a food sample.
    Type: Application
    Filed: April 1, 2014
    Publication date: February 18, 2016
    Inventors: Marie CELLIER, Marie-Pierre BOURGUIGNON, Diane HALIMI, Sylvain ORENGA
  • Publication number: 20150329897
    Abstract: A microorganism detection medium, said detection being based on showing the presence of a microbial enzyme activity chosen from esterase and/or osidase and/or peptidase and/or sulfatase and/or phosphatase activities of microorganisms, preferably said microbial enzyme activity being an esterase activity, said medium comprising: at least one chromogenic and/or fluorogenic substrate specific to the enzyme activity sought, preferably specific to an esterase activity, at least one alkyl(thio)glycoside, at least one solvent (S).
    Type: Application
    Filed: December 24, 2013
    Publication date: November 19, 2015
    Inventors: MARIE CELLIER, SYLVAIN ORENGA, JOHN PERRY