Patents by Inventor Sylvestre Bonnet

Sylvestre Bonnet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Photoactivatable cancer prodrug
    Patent number: 10781226
    Abstract: Described herein is photocaging methodology using ruthenium (II) complexes with 7-deazahypoxanthine-based anticancer agents. Specifically, 7-deazahypoxanthines are converted into photoactivatable chemotherapeutic agents for the controlled release of these toxic agents selectively into tumor tissue upon irradiation with light.
    Type: Grant
    Filed: October 19, 2017
    Date of Patent: September 22, 2020
    Assignees: Texas State University, Leiden University
    Inventors: Alexander Kornienko, Tania Betan-Court, Sylvestre Bonnet, Vincent Van Rixel
  • PHOTOACTIVATABLE CANCER PRODRUG
    Publication number: 20200239503
    Abstract: Described herein is photocaging methodology using ruthenium (II) complexes with 7-deazahypoxanthine-based anticancer agents. Specifically, 7-deazahypoxanthines are converted into photoactivatable chemotherapeutic agents for the controlled release of these toxic agents selectively into tumor tissue upon irradiation with light.
    Type: Application
    Filed: October 19, 2017
    Publication date: July 30, 2020
    Inventors: Alexander Kornienko, Tania Betan-Court, Sylvestre Bonnet, Vincent Van Rixel
  • Light induced drug release
    Patent number: 9255118
    Abstract: Photosensitive compounds for use in a method of treating a disease or condition are described. The photosensitive compounds have the formula R—Y, wherein R is a ruthenium complex and Y is at least one sulphur-containing photoreleasable group, and the compounds comprise at least one ruthenium-sulphur bond; or a pharmaceutically acceptable salt, solvate, ester or amide, such that upon influence of visible or near infra-red light (400-1400 nm) in vivo, said at least one ruthenium-sulphur bond is broken, thereby generating a pharmacologically active compound.
    Type: Grant
    Filed: October 18, 2011
    Date of Patent: February 9, 2016
    Assignee: UNIVERSITEIT LEIDEN
    Inventor: Sylvestre Bonnet
  • LIGHT INDUCED DRUG RELEASE
    Publication number: 20140148425
    Abstract: Photosensitive compounds for use in a method of treating a disease or condition are described. The photosensitive compounds have the formula R—Y, wherein R is a ruthenium complex and Y is at least one sulphur-containing photoreleasable group, and the compounds comprise at least one ruthenium-sulphur bond; or a pharmaceutically acceptable salt, solvate, ester or amide, such that upon influence of visible or near infra-red light (400-1400 nm) in vivo, said at least one ruthenium-sulphur bond is broken, thereby generating a pharmacologically active compound.
    Type: Application
    Filed: October 18, 2011
    Publication date: May 29, 2014
    Inventor: Sylvestre Bonnet