Patents by Inventor Sylvia Degrado

Sylvia Degrado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS
    Publication number: 20200061079
    Abstract: Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.
    Type: Application
    Filed: June 27, 2019
    Publication date: February 27, 2020
    Inventors: Jagath R. JUNUTULA, Sean W. SMITH, Dmitry BORKIN, Sylvia DEGRADO, Sanjeevani GHONE
  • Isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers
    Patent number: 10350218
    Abstract: Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.
    Type: Grant
    Filed: February 23, 2018
    Date of Patent: July 16, 2019
    Assignee: Cellerant Therapeutics, Inc.
    Inventors: Jagath R. Junutula, Sean W. Smith, Dmitry Borkin, Sylvia Degrado, Sanjeevani Ghone
  • ISOQUINOLIDINOBENZODIAZEPINE (IQB)-1(CHLOROMETHYL)-2,3-DIHYDRO-1H-BENZO[E]INDOLE (CBI) DIMERS
    Publication number: 20180177795
    Abstract: Provided herein are isoquinolidinobenzodiazepine (IQB)-1(chloromethyl)-2,3-dihydro-1H-benzo[e]indole (CBI) dimers, antibody-drug conjugates comprising them and methods of use for killing cells and treating disease.
    Type: Application
    Filed: February 23, 2018
    Publication date: June 28, 2018
    Inventors: Jagath R. JUNUTULA, Sean W. Smith, Dmitry Borkin, Sylvia Degrado, Sanjeevani Ghone
  • Fused tricyclic compounds for the treatment of inflammatory disorders
    Patent number: 8598158
    Abstract: The present invention relates to certain lactam ring-containing compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein D, E, X1, R1, R2, R3, R4, R9, and R10 are as herein described. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma, and chronic obstructive pulmonary disorder.
    Type: Grant
    Filed: December 9, 2010
    Date of Patent: December 3, 2013
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Dong Xiao, Anandan Palani, Robert G. Aslanian, Sylvia Degrado, Xianhai Huang, Wei Zhou, Michael Sofolarides, Xiao Chen
  • FUSED TRICYCLIC COMPOUNDS FOR THE TREATMENT OF INFLAMMATORY DISORDERS
    Publication number: 20120316154
    Abstract: The present invention relates to certain lactam ring-containing compounds of the Formula (I) and pharmaceutically acceptable salts thereof, wherein D, E, X1, R1, R2, R3, R4, R9, and R10 are as herein described. In addition, the invention relates to pharmaceutically acceptable compositions comprising at least one such compound, and methods of using the compounds for treating or preventing various inflammatory disorders such as rheumatoid arthritis, inflammatory bowel disease, psoriasis, asthma, and chronic obstructive pulmonary disorder.
    Type: Application
    Filed: December 9, 2010
    Publication date: December 13, 2012
    Inventors: Dong Xiao, Anandan Palani, Robert G Aslanian, Sylvia Degrado, Xianhai Huang, Wei Zhou, Michael Sofolarides, Xiao Chen
  • Azine Derivatives and Methods of Use Thereof
    Publication number: 20110207734
    Abstract: The present invention relates to Azine Derivatives, pharmaceutical compositions comprising the Azine Derivatives and the use of these compounds for treating or preventing allergy, an allergy-induced airway response, congestion, a cardiovascular disease, an inflammatory disease, a gastrointestinal disorder, a neurological disorder, a metabolic disorder, obesity or an obesity-related disorder, diabetes, a diabetic complication, impaired glucose tolerance or impaired fasting glucose.
    Type: Application
    Filed: April 14, 2011
    Publication date: August 25, 2011
    Inventors: Anandan Palani, Dong Xiao, Robert G. Aslanian, Michael Y. Berlin, Ashwin U. Rao, Xiao Chen, Yoon Joo Lee, Sylvia Degrado, Ning Shao, Ying R. Huang, Zhidan Liu
  • NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF
    Publication number: 20080019978
    Abstract: The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: and L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
    Type: Application
    Filed: June 29, 2007
    Publication date: January 24, 2008
    Inventors: Anandan Palani, Jing Su, Dong Xiao, Xianhai Huang, Ashwin Rao, Xiao Chen, Haiqun Tang, Jun Qin, Ying Huang, Robert Aslanian, Brian McKittrick, Sylvia Degrado
  • Nitrogen-containing heterocyclic compounds and methods of use thereof
    Publication number: 20070066630
    Abstract: The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: L is selected from the group consisting of: ?pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
    Type: Application
    Filed: November 15, 2006
    Publication date: March 22, 2007
    Inventors: Anandan Palani, Jing Su, Dong Xiao, Xianhai Huang, Ashwin Rao, Xiao Chen, Haiqun Tang, Jun Qin, Ying Huang, Robert Aslanian, Brian McKittrick, Sylvia Degrado