Patents by Inventor Sylvia J. Degrado

Sylvia J. Degrado has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Cytotoxic agents and conjugates thereof
    Patent number: 10654873
    Abstract: Provided herein are novel maytansinoid compounds of general formula I. Also provided herein are conjugates comprising the compounds linked to a binding protein via a linker, and conjugating reagents comprising the compounds attached via a linker to at least one functional group capable of reacting with a binding protein. Also provided herein are pharmaceutical compositions comprising the compounds and conjugates, therapeutic methods and uses involving the compounds and conjugates, for example in cancer therapy, and novel synthetic processes.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: May 19, 2020
    Assignee: POLYTHERICS LIMITED
    Inventors: Nareshkumar Jain, Sanjeevani Ghone, Sean Smith, Ian Glassford, Sylvia J. Degrado, Fu-an Kang, Senzhi Zhao
  • Novel Cytotoxic Agents And Conjugates Thereof
    Publication number: 20190202839
    Abstract: Provided herein are novel maytansinoid compounds of general formula I. Also provided herein are conjugates comprising the compounds linked to a binding protein via a linker, and conjugating reagents comprising the compounds attached via a linker to at least one functional group capable of reacting with a binding protein. Also provided herein are pharmaceutical compositions comprising the compounds and conjugates, therapeutic methods and uses involving the compounds and conjugates, for example in cancer therapy, and novel synthetic processes.
    Type: Application
    Filed: September 15, 2017
    Publication date: July 4, 2019
    Inventors: Nareshkumar JAIN, Sanjeevani GHONE, Sean SMITH, Ian GLASSFORD, Sylvia J. DEGRADO, Fu-an KANG, Senzhi ZHAO
  • Aminoquinazoline compounds as Aantagonist
    Patent number: 10138212
    Abstract: The present invention is directed to compounds of generic formula I: or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist.
    Type: Grant
    Filed: February 1, 2016
    Date of Patent: November 27, 2018
    Assignee: Merck Sharp & Dohme Corp.
    Inventors: Amjad Ali, Rongze Kuang, Yeon-Hee Lim, Michael Man-Chu Lo, Pauline C. Ting, Purakkattle Biju, Manuel de Lera Ruiz, Sylvia J. Degrado, Alexander L. Tung, Timothy J. Henderson, Liwu Hong, Jae-Hun Kim, Dong Won-Shik Kim, Joe Lee, Jie Wu, Heping Wu, Yushi Xiao, Tao Yu, Gang Zhou, Xiaohong Zhu, Kevin D. McCormick, Jayaram R. Tagat, Dong Xiao, Tanweer Khan, Jianhua Cao, Michael Berlin, Yonglian Zhang
  • AMINOQUINAZOLINE COMPOUNDS AS A2A ANTAGONIST
    Publication number: 20180037554
    Abstract: The present invention is directed to compounds of generic formula I: or pharmaceutically acceptable salts thereof that are believed to be useful as an A2A-receptor antagonist.
    Type: Application
    Filed: February 1, 2016
    Publication date: February 8, 2018
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Amjad Ali, Rongze Kuang, Yeon-Hee Lim, Michael Man-Chu Lo, Pauline C. Ting, Purakkattle Biju, Manuel de Lera Ruiz, Sylvia J. Degrado, Alexander L. Tung, Timothy J. Henderson, Liwu Hong, Jae-Hun Kim, Dong Won-Shik Kim, Joe Lee, Jie Wu, Heping Wu, Yushi Xiao, Tao Yu, Gang Zhou, Xiaohong Zhu, Kevin D. McCormick, Jayaram R. Tagat, Dong Xiao, Tanweer Khan, Jianhua Cao, Michael Berlin, Yonglian Zhang
  • Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia
    Patent number: 7763623
    Abstract: A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, or tautomer thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome and dyslipidemia.
    Type: Grant
    Filed: January 17, 2007
    Date of Patent: July 27, 2010
    Assignee: Schering Corporation
    Inventors: Anandan Palani, Jun Qin, Dong Xiao, Ying R. Huang, Xiao Chen, Zhidan Liu, Sylvia J. Degrado, Robert G. Aslanian, Xianhai Huang
  • Nitrogen-containing heterocyclic compounds and methods of use thereof
    Patent number: 7750015
    Abstract: The present invention provides compounds of Formula (I): and pharmaceutically acceptable salts, solvates, esters, and tautomers thereof, wherein: Q is selected from the group consisting of: L is selected from the group consisting of: pharmaceutically compositions comprising one or more compounds of formula (I), and methods of using the compounds of formula (I).
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: July 6, 2010
    Assignee: Schering Corporation
    Inventors: Anandan Palani, Dong Xiao, Xianhai Huang, Ashwin U. Rao, Xiao Chen, Jun Qin, Ying R. Huang, Robert G. Aslanian, Sylvia J. Degrado
  • Heterocycles as nicotinic acid receptor agonists for the treatment of dyslipidemia
    Publication number: 20070173495
    Abstract: A compound having the general structure of Formula (I): or a pharmaceutically acceptable salt, solvate, ester, or tautomer thereof, are useful in treating diseases, disorders, or conditions such as metabolic syndrome and dyslipidemia.
    Type: Application
    Filed: January 17, 2007
    Publication date: July 26, 2007
    Inventors: Anandan Palani, Jun Qin, Dong Xiao, Ying R. Huang, Xiao Chen, Zhidan Liu, Sylvia J. Degrado, Robert G. Aslanian, Xianhai Huang