Patents by Inventor Sylvia Rottach

Sylvia Rottach has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for determining the amount of a therapeutic antibody in the brain
    Patent number: 11913945
    Abstract: Herein is reported a method for determining the concentration of a therapeutic antibody in a tissue of an experimental animal to whom the therapeutic antibody had been administered, wherein the interference from residual blood in a tissue sample of the experimental animal, which is used for determining the concentration of the therapeutic antibody in said tissue, is reduced by applying an inert reference antibody that does not penetrate into said tissue, whereby the inert reference antibody is administered 2 to 10 minutes prior to obtaining the tissue and blood sample.
    Type: Grant
    Filed: December 29, 2020
    Date of Patent: February 27, 2024
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Martin Schaefer, Sylvia Rottach, Gregor Jordan, Kay-Gunnar Stubenrauch, Roland Staack, Kevin Brady
  • METHOD FOR DETERMINING THE AMOUNT OF A THERAPEUTIC ANTIBODY IN THE BRAIN
    Publication number: 20220357340
    Abstract: Herein is reported a method for determining the concentration of a therapeutic antibody in a tissue of an experimental animal to whom the therapeutic antibody had been administered, wherein the interference from residual blood in a tissue sample of the experimental animal, which is used for determining the concentration of the therapeutic antibody in said tissue, is reduced, wherein the concentration of the therapeutic antibody in the tissue of the experimental animal is calculated with the following formula: C tmAb , tissue = C t ? m ? A ? b , tissue , det . C t ? i ? s ? sue , sample - C r ? e ? f ? m ? A ? b , tissue , det . C t ? i ? s ? sue , sample C r ? e ? f ? m ? A ? b , plasma . det . * C t ? m ? A ? b , plasma , det . wherein CtmAb,tissue,det.=obtained by determining the concentration of the therapeutic antibody in the tissue sample of the experimental animal, CtmAb,plasma,det.
    Type: Application
    Filed: June 14, 2022
    Publication date: November 10, 2022
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Kevin BRADY, Gregor JORDAN, Sylvia ROTTACH, Martin SCHAEFER, Roland STAACK, Kay-Gunnar STUBENRAUCH
  • METHOD FOR DETERMINING THE AMOUNT OF A THERAPEUTIC ANTIBODY IN THE BRAIN
    Publication number: 20210364504
    Abstract: Herein is reported a method for determining the concentration of a therapeutic antibody in a tissue of an experimental animal to whom the therapeutic antibody had been administered, wherein the interference from residual blood in a tissue sample of the experimental animal, which is used for determining the concentration of the therapeutic antibody in said tissue, is reduced, wherein the concentration of the therapeutic antibody in the tissue of the experimental animal is calculated with the following formula: C tmAb , tissue = C tmAb , tissue , det . C tissue , sample - C refmAb , tissue , det . C tissue , sample C refmAb , plasma . det . * C tmAb , plasma , det . wherein CtmAb,tissue,det.=obtained by determining the concentration of the therapeutic antibody in the tissue sample of the experimental animal, CtmAb,plasma,det.
    Type: Application
    Filed: December 29, 2020
    Publication date: November 25, 2021
    Applicant: Hoffmann-La Roche Inc.
    Inventors: Martin Schaefer, Sylvia Rottach, Gregor Jordan, Kay-Gunnar Stubenrauch, Roland Staack, Kevin Brady