Abstract: The present invention relates to a method for producing renewable aviation fuel D or components thereto from a feed-stock A of biological origin, in particular to methods comprising separate hydrodeoxygenation 20 and hydroisomerization 40 steps wherein the hydroisomerization is performed in the presence of a catalyst comprising a noble metal, a 12-membered ring zeolite with a pore size below 0.7 nm.

Abstract: A method for removing hair from textiles using a detergent and/or detergent additive including at least one protease, at least one bleaching agent, and at least one bleach activator is described. Use of a detergent and/or detergent additive including at least one protease, at least one bleaching agent, and at least one bleach activator for removing hair from textiles is also described. Use of a protease for removing hair from textiles is also described.

Abstract: Embodiments of the invention include additional methods and compositions for fabricating organoids. A unique approach has been developed for the rapid aggregation of defined number of cells using a micropillar-based template to limit the size of organoids, which are then more commonly referred to as spheroids. This procedure can be utilized to create in vitro cardiac tissue models (e.g., cardiac organoids) simply, rapidly, and inexpensively. In certain aspects an alginate-gelatin based hydrogel premixed with cardiomyocytes is used in combination with a patterned microfluidic chip/cell culture chamber having an array of micropillars to fabricate 3D cardiac organoids.

Abstract: A system includes a stage for supporting a sample having at least first and second atomic elements. The first atomic element has a first characteristic x-ray line with a first energy and the second atomic element has a second characteristic x-ray line with a second energy, the first and second energies lower than 8 keV and separated from one another by less than 1 keV. The system further includes an x-ray source of x-rays having a third energy between the first and second energies and at least one x-ray optic configured to receive and focus at least some of the x-rays as an x-ray beam to illuminate the sample. The system further includes at least one x-ray detector configured to detect fluorescence x-rays produced by the sample in response to being irradiated by the x-ray beam.

Abstract: Antibody for human amyloid beta. Antibody selectively binds human amyloid beta 42 peptide over human amyloid beta 40 peptide. Antibodies specific for amyloid beta 42 as therapeutic agents for binding amyloid beta 42 peptide and treating conditions associated with amyloidosis, such as Alzheimer's disease.

Abstract: The present disclosure is directed to a device for supporting manual pipetting of liquids, to the use of such a pipetting support device, and to a method for pipetting liquid, for example from a number of first vessels to a number of second vessels, wherein a moving unit is movable in relation to a first plate and at least partially covers the first plate during use of the pipetting support device, and at least one edge of the moving unit provides guidance to support a manual pipetting procedure from said first plate to said second plate, or vice versa.

Abstract: A graphical user interface (GUI) of a gaming device displays a first option to play a bonus game at the first multiplier value and a second option to increase the first multiplier value for a future bonus game. Based on a selection of the first option by a player, the gaming device initiates the bonus game, generates a bonus game result, determines a first bonus game award based on the bonus game result, multiplies the first bonus game award based on the first multiplier to generate a first total bonus game award, and awards the first total bonus game award to the player. Based on a selection of the second option by the player, the gaming device increases the first multiplier value to a second multiplier value higher than the first multiplier value, removes the first bonus game trigger condition, and resumes play of the base wagering game.

Abstract: The invention relates to improved culture methods for expanding epithelial stem cells and obtaining organoids, to culture media involved in said methods, and to uses of said organoids.

Abstract: A vehicle seat arrangement has at least two seats, which are arranged next to one another in a transverse direction of the seat on a common seat bench, and a common seat backrest that can be inclined about a transverse axis. The common seat backrest is adjustable from an upright seating position into a resting or reclined position which is inclined towards the rear.

Abstract: Exemplary multi-unit dose dry powder inhaler devices may be provided with a housing body having a swirl chamber therein, at least one air inlet, a mouthpiece, a rotatable downfall wheel having at least two capsule spaces that are each configured to hold a capsule, a drive mechanism configured to repeatably index the downfall wheel in a predefined angular increment such that one of the capsule spaces moves adjacent to the swirl chamber each time the downfall wheel is indexed, and a pair of side ramps adjacent to the swirl chamber and the downfall wheel. The side ramps may be configured to cooperate with center ramps located in the capsule spaces to drive a capsule radially outward from a capsule space and into the swirl chamber, thereby enabling the device to automatically load multiple capsules one at a time sequentially into the swirl chamber. Methods of use are also provided.

Abstract: The invention relates to a dry-connection stud having a web and a first and second flange connected to the web, wherein flange beads are provided in at least one of the flanges, wherein the flange beads each extend in the longitudinal direction of the stud over a flange bead length that is less than an overall length of the stud, wherein the flange beads are disposed at a center distance from each other. The invention further relates to a dry-construction wall with such a dry-construction stud.

Abstract: A computer implemented method of determining which stored data items are most similar to a received data item. For each stored data item, first and second vectors are generated and compared to generate a similarity score. Stored data items are classified as similar to the received data item using the similarity scores. The vectors are defined within the same vector space. The first vector includes a first component indicative of a number of unique N-grams of the received data item relative to the stored data item and a further component indicative of a number of common N-grams in the received data item and the stored data item. The second vector includes first component indicative of a number of unique N-grams of the stored data item, and a further component indicative of a number of common N-grams in the received data item and the stored data item.

Abstract: An engineered material includes a conductive biopolymer including a plurality of layers, each of which includes methacrylated hyaluronic acid conjugated with at least one of 3-thiophene acetic acid and with poly(3-thiophene) acetic acid; and myocytes. The myocytes can include iPSC-derived cardiomyocytes. The myocytes can be substantially aligned in single lines. The single lines can be approximately parallel to one another and approximately normal to planes defined by the plurality of layers. A method of 3D printing the layers is also described.

Abstract: The present invention provides compositions and methods relating to or derived from antigen binding proteins activate FGF21-mediated signaling. In embodiments, the antigen binding proteins specifically bind to (i) ?-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising Q-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to (i) ?-Klotho; (ii) FGFR1c, FGFR2c, FGFR3c or FGFR4; or (iii) a complex comprising ?-Klotho and one of FGFR1c, FGFR2c, FGFR3c, and FGFR4.

Abstract: An apparatus includes an x-ray source configured to generate x-rays, at least some of which impinge a sample and at least one diffractor configured to concurrently diffract at least some of the x-rays from the sample in a first direction and in a second direction substantially orthogonal to the first direction. The apparatus further includes at least one two-dimensional (2D) position-sensitive x-ray detector configured to receive at least some of the diffracted x-rays and to concurrently generate first spectral information of the x-rays diffracted in the first direction and second spectral information of the x-rays diffracted in the second direction. The apparatus further includes circuitry configured to receive the first and second spectral information and to generate a single x-ray absorption spectroscopy (XAS) spectrum using the first and second spectral information.

Abstract: The present invention relates to a method for determining the composition of a multi-layer system showing a predetermined colour flip-flop effect, wherein the multi-layer system comprises from bottom to top a) a substrate, b) at least one first colour layer containing a colourant, which is arranged on the substrate a), c) on the at least one first colour layer an effect layer containing at least one platelet-shaped effect pigment, and d) on the effect layer c) at least one second colour layer containing a colourant, wherein each of the at least one first colour layer and of the at least one second colour layer contains a colourant being no platelet-shaped effect pigment, wherein the method comprises the following steps: i) specifying a first target value for the colour shade and/or colour brightness of the top side of the multi-layer system seen at a first observation angle, ii) specifying a second target value for the colour shade and/or colour brightness of the top side of the multi-layer system seen at a s

Abstract: Antigen binding proteins that bind to human CGRP receptor (CGRP R) are provided. Nucleic acids encoding the antigen binding protein, vectors, and cells encoding the same are also provided. The antigen binding proteins can inhibit binding of CGRP R to CGRP, and are useful in a number of CGRP R related disorders, including the treatment and/or prevention of migraine headaches.

Abstract: The present invention relates to compounds of formula (I): for use as peripheral NMDA receptor antagonists.