Abstract: The present disclosure relates to an isolated protein that inhibits the CD9P-1 pathway, preferably that inhibits the CD9P-1stabilin-1 pathway and/or the CD9P-1TRAF-2 pathway, in particular to an isolated antibody against human CD9P-1, and to the use thereof in therapeutic or diagnostic methods.

Abstract: The present invention relates to specific polypeptides having anti-angiogenic activity and their use for treating cancer.

Abstract: The present invention relates to a composition or kit of parts comprising an inhibitor of IRS-1 and an inhibitor of the VEGF pathway and to the use thereof for treating an angiogenic disease.

Abstract: The present invention relates to a composition comprising a phosphorothioate oligonucleotide and at least one fatty acid and/or at least one emulsifying agent, wherein said composition is sterile and wherein said composition comprises an agent comprising a thiol group, preferably said composition is an ophthalmic composition; to a method for obtaining the same and to the therapeutic use thereof.

Abstract: A method for the treatment of cancers and/or tumors by administration of a polypeptide having the sequence SEQ ID NO:4 or a polypeptide having an amino acid SEQ ID NO Y which, when aligned with SEQ ID N: 4, has (a) a percentage of identical residues over SEQ ID NO: 4 length of at least 50%, and (b) a percentage of identical residues over a amino acid sequence SEQ ID NO Y length of at least 65% or fragments thereof having at least 20 contiguous amino acids.

Abstract: The present invention relates to an inhibitor of the expression of IRS-1 for treating an angiogenic and/or inflammatory skin disease. The present invention also relates to a transdermal composition, preferably an ointment, comprising an inhibitor of the expression of IRS-1, and to the use thereof for treating an angiogenic and/or inflammatory skin disease.

Abstract: The present invention relates to peptide from 4 to 50 amino acids comprising a phosphorylated pYX1X2X1 motif (SEQ ID NO: 1), wherein each X1 independently is M or Nle and X2 is any amino acid, pharmaceutical compositions comprising said peptide and use thereof for treating cancer.

Abstract: The present invention relates to an inhibitor of the expression of IRS-1 for treating an angiogenic and/or inflammatory skin disease. The present invention also relates to a transdermal composition, preferably an ointment, comprising an inhibitor of the expression of IRS-1, and to the use thereof for treating an angiogenic and/or inflammatory skin disease.

Abstract: An active polypeptide comprising the amino acid sequence of SEQ ID NO:4, having an anti-tumor activity, and compositions and methods including the active polypeptide.

Abstract: A method for the treatment of cancers and/or tumors by administration of a polypeptide having the sequence SEQ ID NO:4 or a polypeptide having an amino acid SEQ ID NO Y which, when aligned with SEQ ID N: 4, has (a) a percentage of identical residues over SEQ ID NO: 4 length of at least 50%, and (b) a percentage of identical residues over a amino acid sequence SEQ ID NO Y length of at least 65% or fragments thereof having at least 20 contiguous amino acids.

Abstract: The present invention relates to a composition or kit of parts comprising an inhibitor of IRS-1 and an inhibitor of the VEGF pathway and to the use thereof for treating an angiogenic disease.

Abstract: The present invention relates to an inhibitor of the expression of IRS-1 for treating an angiogenic and/or inflammatory skin disease. The present invention also relates to a transdermal composition, preferably an ointment, comprising an inhibitor of the expression of IRS-1, and to the use thereof for treating an angiogenic and/or inflammatory skin disease.

Abstract: The present invention relates to peptide from 4 to 50 amino acids comprising a phosphorylated pYX1X2X1 motif (SEQ ID NO: 1), wherein each X1 independently is M or Nle and X2 is any amino acid, pharmaceutical compositions comprising said peptide and use thereof for treating cancer.

Abstract: The present invention relates to new peptides, pharmaceutical composition and cosmetic composition comprising them and their use for wound healing.

Abstract: This invention relates to a pharmaceutical composition for the treatment and/or prevention of at least one pathological neovascularization-related conditions of the interior of the eye, the composition comprising a therapeutically effective amount of an antisens oligonucleotide having the sequence SEQ ID NO: 1: 5?-TCTCCGGAGGGCTCGCCATGCTGCT-3? or any function conservative sequence comprising from 9 to 30 nucleotides that has 75%, 80%, 85%, 90%, 95% or more than 95%, 96%, 97%, 98%, 99% of identity compared to SEQ ID NO: 1 and that conserves the capacity of inhibiting IRS-1 gene expression as SEQ ID NO: 1, and the composition being administered within the posterior segment of the eye to a subject in need thereof; this invention also relates to a method for treating a pathological neovascularization-related condition of the interior of the eye in a subject in need thereof comprising administering to the subject a therapeutically effective amount of said pharmaceutical composition.

Abstract: The present invention relates to peptide from 4 to 50 amino acids comprising a phosphorylated pYX1X2X1 motif (SEQ ID NO: 1), wherein each X1 independently is M or Nle and X2 is any amino acid, pharmaceutical compositions comprising said peptide and use thereof for treating cancer.

Abstract: The present invention relates to an active polypeptide including the amino acid sequence of SEQ ID NO:3, or having at least 50%, preferably 70%, more preferably 90% identity with the amino acid sequence of SEQ ID NO:3, or fragments thereof having at least 21 contiguous amino acids, or peptides having at least 50%, preferably 70%, more preferably 90% identity with the amino acid sequence of the fragments, provided that the polypeptide is not SEQ ID NO:2, variants and antigenic fragments thereof, SEQ ID NO 16 or SEQ ID NO 17, and uses thereof in a method of treating cancer and/or tumours of the human or animal body.

Abstract: Compositions comprising an inhibitor of IRS-1 and an inhibitor of the VEGF pathway, which compositions rare useful for treating an angiogenic disease. The specification also relates to kits comprising an inhibitor of IRS-1 and an inhibitor of the VEGF pathway, as well as methods of treating angiogenic diseases using such compositions and/or kits.

Abstract: The present invention relates to new peptides, pharmaceutical composition and cosmetic composition including them and their use for wound healing.

Abstract: The present invention relates to peptide from 4 to 50 amino acids comprising a phosphorylated pYX1X2X1 motif (SEQ ID NO: 1), wherein each X1 independently is M or Nle and X2 is any amino acid, pharmaceutical compositions comprising said peptide and use thereof for treating cancer.