Patents by Inventor Sylvie Garneau-Tsodikova

Sylvie Garneau-Tsodikova has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antifungal compounds and methods of forming the same
    Patent number: 11851391
    Abstract: An antifungal composition and a method of treating a systemic fungal infection are provided herein. The antifungal composition includes a diaryl bishydrazone. The method includes administering a therapeutically effective amount of the diaryl bishydrazone to a subject in need thereof.
    Type: Grant
    Filed: July 17, 2019
    Date of Patent: December 26, 2023
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvie Garneau-Tsodikova, David S. Watt, Nishad Thamban Chandrika
  • ANTIMICROBIAL COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20230136598
    Abstract: The presently-disclosed subject matter generally relates to antimicrobial compounds, compositions, methods of making and methods of use thereof. The presently-disclosed subject matter further relates to compounds, compositions and methods for the control of Porphyromonas gingivalis.
    Type: Application
    Filed: December 27, 2022
    Publication date: May 4, 2023
    Inventors: Sylvie Garneau-Tsodikova, Octavio Alberto Gonzalez
  • Distorted gold (I)-phosphine complexes and and methods for use as antifungal agents
    Patent number: 11564394
    Abstract: The presently-disclosed subject matter describes distorted gold (I) phosphine compounds. The presently-disclosed subject matter also describes a method for killing fungus comprising contacting fungus with distorted gold (I) phosphine compounds. The presently-disclosed subject matter further describes a method of preventing or disrupting a biofilm on a surface comprising contacting a surface with distorted gold (I) phosphine compounds.
    Type: Grant
    Filed: December 10, 2020
    Date of Patent: January 31, 2023
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvie Garneau-Tsodikova, Emily K Dennis, Jong Hyun Kim, Samuel G. Awuah
  • Antimicrobial compounds, compositions, and method
    Patent number: 11535592
    Abstract: The presently-disclosed subject matter generally relates to antimicrobial compounds, compositions, methods of making and methods of use thereof. The presently-disclosed subject matter further relates to compounds, compositions and methods for the control of Porphyromonas gingivalis.
    Type: Grant
    Filed: June 8, 2020
    Date of Patent: December 27, 2022
    Assignee: UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION
    Inventors: Sylvie Garneau-Tsodikova, Octavio Alberto Gonzalez
  • Combination of a DNA condensation-inducing compound and an Eis inhibitor for antibiotic treatment
    Patent number: 11103504
    Abstract: A method of killing bacteria and an antibiotic kit are provided herein. The method includes treating the bacteria with a DNA condensation-inducing compound; and subsequently treating the bacteria with an Eis inhibitor. The kit includes a DNA condensation-inducing compound packaged together with an Eis inhibitor.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: August 31, 2021
    Assignees: University of Kentucky Research Foundation, Academisch Medisch Centrum
    Inventors: Sylvie Garneau-Tsodikova, Nicole Neeltje van der Wel
  • DISTORTED GOLD (I)-PHOSPHINE COMPLEXES AND AND METHODS FOR USE AS ANTIFUNGAL AGENTS
    Publication number: 20210195903
    Abstract: The presently-disclosed subject matter describes distorted gold (I) phosphine compounds. The presently-disclosed subject matter also describes a method for killing fungus comprising contacting fungus with distorted gold (I) phosphine compounds. The presently-disclosed subject matter further describes a method of preventing or disrupting a biofilm on a surface comprising contacting a surface with distorted gold (I) phosphine compounds.
    Type: Application
    Filed: December 10, 2020
    Publication date: July 1, 2021
    Inventors: Sylvie Garneau-Tsodikova, Emily K Dennis, Jong Hyun Kim, Samuel G. Awuah
  • ANTIMICROBIAL COMPOUNDS, COMPOSITIONS, AND METHODS
    Publication number: 20200385348
    Abstract: The presently-disclosed subject matter generally relates to antimicrobial compounds, compositions, methods of making and methods of use thereof. The presently-disclosed subject matter further relates to compounds, compositions and methods for the control of Porphyromonas gingivalis.
    Type: Application
    Filed: June 8, 2020
    Publication date: December 10, 2020
    Inventors: Sylvie Garneau-Tsodikova, Octavio Alberto Gonzalez
  • IMMOBILIZED MULTI-ENZYMATIC HALOGENATION SYSTEM
    Publication number: 20200299671
    Abstract: A halogenation system, a method of halogenating a substrate, and halogenated compounds are provided. The halogenation system includes PltM immobilized on a solid support. The system may include one or more additional enzymes immobilized on the solid support. The method of halogenating a substrate includes running the substrate and a reaction solution through the halogenation system including PltM immobilized on a solid support. The halogenated compounds include 4,6-diCl-3, 4,6-diCl-8, 2,4-diCl-9, 2,6-diCl-11, 3,5-diCl-15, 4,6-diCl-16, 4,6-diCl-18, 4-Cl-23, and/or 4,6-diBr-3.
    Type: Application
    Filed: March 19, 2020
    Publication date: September 24, 2020
    Inventors: Sylvie Garneau-Tsodikova, Oleg V. Tsodikov, Shogo Mori, Michael D. Burkart, James J. La Clair
  • Identification of ebsulfur analogues with broad-spectrum antifungal activity
    Patent number: 10544112
    Abstract: The invention relates to novel ebsulfur analogues and novel pharmaceutical compositions comprising ebsulfur analogues. The invention also relates to novel methods of treating infections caused by fungal species comprising administration of ebselen, ebsulfur, and ebsulfur analogues.
    Type: Grant
    Filed: March 29, 2018
    Date of Patent: January 28, 2020
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvie Garneau-Tsodikova, Huy X. Ngo, Sanjib K. Shrestha
  • ANTIFUNGAL COMPOUNDS AND METHODS OF FORMING THE SAME
    Publication number: 20200024224
    Abstract: An antifungal composition and a method of treating a systemic fungal infection are provided herein. The antifungal composition includes a diaryl bishydrazone. The method includes administering a therapeutically effective amount of the diaryl bishydrazone to a subject in need thereof.
    Type: Application
    Filed: July 17, 2019
    Publication date: January 23, 2020
    Inventors: Sylvie Garneau-Tsodikova, David S. Watt, Nishad Thamban Chandrika
  • COMBINATION OF A DNA CONDENSATION-INDUCING COMPOUND AND AN EIS INHIBITOR FOR ANTIBIOTIC TREATMENT
    Publication number: 20200022978
    Abstract: A method of killing bacteria and an antibiotic kit are provided herein. The method includes treating the bacteria with a DNA condensation-inducing compound; and subsequently treating the bacteria with an Eis inhibitor. The kit includes a DNA condensation-inducing compound packaged together with an Eis inhibitor.
    Type: Application
    Filed: July 22, 2019
    Publication date: January 23, 2020
    Inventors: Sylvie Garneau-Tsodikova, Nicole Neeltje van der Wel
  • Eis inhibitors
    Patent number: 10253035
    Abstract: Compounds and compositions are disclosed, which are useful as inhibitors of acetyltransferase Eis, a mediator of kanamycin resistance in Mycobacterium tuberculosis.
    Type: Grant
    Filed: December 8, 2017
    Date of Patent: April 9, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvie Garneau-Tsodikova, Oleg V. Tsodikov
  • Eis inhibitors
    Patent number: 10208000
    Abstract: Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.
    Type: Grant
    Filed: December 16, 2016
    Date of Patent: February 19, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvie Garneau-Tsodikova, Oleg V. Tsodikov, James E. Posey
  • Antifungal Compositions
    Publication number: 20190015400
    Abstract: Provided herein are antifungal compositions and methods of use thereof. The antifungal compositions include an antifungal agent and an antipsychotic agent or an antihistamine. The methods of use thereof include administering a composition including an antifungal agent and an antipsychotic or an antihistamine to a plant or animal in need thereof.
    Type: Application
    Filed: July 17, 2018
    Publication date: January 17, 2019
    Inventors: Sylvie Garneau-Tsodikova, Atefeh Garzan, Selina Yijia Li Holbrook, Emily Kristen Dennis
  • Bishydrazone-based antifungal agents
    Patent number: 10173968
    Abstract: Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.
    Type: Grant
    Filed: July 7, 2017
    Date of Patent: January 8, 2019
    Assignee: University of Kentucky Research Foundation
    Inventors: Sylvie Garneau-Tsodikova, David S. Watt
  • Identification of Ebsulfur Analogues with Broad-Spectrum Antifungal Activity
    Publication number: 20180282291
    Abstract: The invention relates to novel ebsulfur analogues and novel pharmaceutical compositions comprising ebsulfur analogues. The invention also relates to novel methods of treating infections caused by fungal species comprising administration of ebselen, ebsulfur, and ebsulfur analogues.
    Type: Application
    Filed: March 29, 2018
    Publication date: October 4, 2018
    Inventors: Sylvie GARNEAU-TSODIKOVA, Huy X. NGO, Sanjib K. SHRESTHA
  • Antifungal Compounds
    Publication number: 20180194742
    Abstract: Compounds and compositions having antifungal activity, and methods of using the antifungal compounds and compositions, are described for use in treating fungal infections.
    Type: Application
    Filed: December 8, 2017
    Publication date: July 12, 2018
    Inventors: Sylvie Garneau-Tsodikova, Sanjib K. Shrestha, Atefeh Garzan, Nishad Thamban Chandrika
  • EIS INHIBITORS
    Publication number: 20180162867
    Abstract: Compounds and compositions are disclosed, which are useful as inhibitors of acetyltransferase Eis, a mediator of kanamycin resistance in Mycobacterium tuberculosis.
    Type: Application
    Filed: December 8, 2017
    Publication date: June 14, 2018
    Inventors: Sylvie Garneau-Tsodikova, Oleg V. Tsodikov
  • BISHYDRAZONE-BASED ANTIFUNGAL AGENTS
    Publication number: 20180009741
    Abstract: Hydrazone compounds and pharmaceutical compositions including same are disclosed as having antifungal activity. Such compounds are useful for treating or preventing fungal conditions in a subject in need thereof by administering same.
    Type: Application
    Filed: July 7, 2017
    Publication date: January 11, 2018
    Inventors: Sylvie Garneau-Tsodikova, David S. Watt
  • EIS INHIBITORS
    Publication number: 20170174639
    Abstract: Provided herein are novel small-molecules that have use in the inhibition of Eis, which mediates kanamycin resistance in Mycobacterium tuberculosis. The presently-disclosed subject matter further includes a pharmaceutical composition including a small molecule inhibitor, as described herein, and a suitable pharmaceutical carrier. Methods of treating tuberculosis comprising administering to an individual an effective amount of the disclosed small molecule inhibitors to mediate kanamycin A resistance and treat tuberculosis are also provided.
    Type: Application
    Filed: December 16, 2016
    Publication date: June 22, 2017
    Inventors: Sylvie Garneau-Tsodikova, Oleg V. Tsodikov, James E. Posey