Patents by Inventor Sylvie Pochet

Sylvie Pochet has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibacterial compounds
    Patent number: 8927520
    Abstract: The present invention relates to compounds of formula (I): wherein Rj, R2, R3, R4, Xi, X2, X3 and Z are as defined in claim 1. The compounds are useful in the prevention and/or treatment of bacterial infections.
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: January 6, 2015
    Assignees: Institut Pasteur, Institut Curie
    Inventors: Sylvie Pochet, Gilles Labesse, Muriel Gelin, Liliane Assairi, Olivier Dussurget, Guillaume Poncet-Montange
  • NOVEL ANTIBACTERIAL COMPOUNDS
    Publication number: 20130331351
    Abstract: The present invention relates to compounds of formula (I): wherein Rj, R2, R3, R4, Xi, X2, X3 and Z are as defined in claim 1. The compounds are useful in the prevention and/or treatment of bacterial infections.
    Type: Application
    Filed: December 22, 2011
    Publication date: December 12, 2013
    Applicants: Institut Pasteur, INSTITUT CURIE, Centre National De la Recherche Scientifique
    Inventors: Sylvie Pochet, Gilles Labesse, Muriel Gelin, Liliane Assairi, Olivier Dussurget, Guillaume Poncet-Montange
  • Combinatorial production of nucleotide and nucleoside (XiTP) analogues
    Publication number: 20100286386
    Abstract: Nucleotide analogues comprising a reactive hydrazide function (formula II) used as initial synthons for preparing compounds (formula I) capable of inducing mutations or capable of inhibiting a DNA polymerase or a kinase provided. Nucleic acids comprising the nucleotide and nucleoside analogues are also provided. Methods of using the compounds are also provided.
    Type: Application
    Filed: November 14, 2007
    Publication date: November 11, 2010
    Inventors: Philippe Marliere, Sylvie Pochet
  • Mutants of Deoxycytidine Kinase Having Extended Enzymatic Activity
    Publication number: 20100136693
    Abstract: The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein Y, X and Y both belonging to the same class of enzyme commission (EC) nomenclature or belonging to related classes. The mutants D133E and R104Q of desoxycytidine kinase (DCK) were obtained; both of said mutations result in acquisition of thymidine kinase activity by DCK.
    Type: Application
    Filed: May 8, 2009
    Publication date: June 3, 2010
    Inventors: Philippe Marliere, Sylvie Pochet, Madeleine Bouzon
  • Mutants of deoxycytidine kinase having extended enzymatic activity
    Patent number: 7547513
    Abstract: The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein Y, X and Y both belonging to the same class of enzyme commission (EC) nomenclature or belonging to related classes. The mutants D133E and R104Q of desoxycytidine kinase (DCK) were obtained; both of said mutations result in acquisition of thymidine kinase activity by DCK.
    Type: Grant
    Filed: May 19, 2005
    Date of Patent: June 16, 2009
    Assignees: Institut Pasteur, Centre National de la Recherche Scientifique (CNRS)
    Inventors: Philippe Marliere, Sylvie Pochet, Madeleine Bouzon
  • Enzymatic synthesis of deoxyribonucleosides
    Publication number: 20080280329
    Abstract: The present invention relates to a method for the in vitro synthesis of deoxyribonucleosides and enzymes suitable for this method.
    Type: Application
    Filed: May 3, 2007
    Publication date: November 13, 2008
    Inventors: Wilhelm Tischer, Hans-Georg Ihlenfeldt, Octavian Barzu, Hiroshi Sakamoto, Elisabeth Pistotnik, Philippe Marliere, Sylvie Pochet
  • Aryl, Pyrimidyl Compounds, Pharmaceutical Compositions Comprising them, Their Use as Antimicrobial Agents
    Publication number: 20080096907
    Abstract: Substituted aryl pyrimidyl compounds responding to formula (I) and their use for the preparation of a medicament for the prevention and/or treatment of a pathology caused by a mycobacteria.
    Type: Application
    Filed: November 4, 2005
    Publication date: April 24, 2008
    Applicants: INSTITUT PASTEUR, INSTITUT NAT. DE LA SANTE DE LA RECHERCHE MED., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Helene Munier-Lehmann, Dominique Douguet, Gilles Labesse, Sylvie Pochet
  • Combinatorial production of nucleotide and nucleoside (XiTP) analogues
    Patent number: 7319148
    Abstract: The invention concerns novel nucleotide analogues comprising a reactive hydrazide function used as initial synthons for preparing compounds (formula I) capable of inducing mutations or capable of inhibiting a DNA polymerase or a kinase. The invention also concerns nucleic acids comprising said nucleotide and nucleoside analogues.
    Type: Grant
    Filed: June 13, 2001
    Date of Patent: January 15, 2008
    Assignee: Institut Pasteur
    Inventors: Philippe Marliere, Sylvie Pochet
  • Enzymatic synthesis of deoxyribonucleosides
    Patent number: 7229797
    Abstract: The present invention relates to a method for the in vitro enzymatic synthesis of deoxyribonucleosides and enzymes suitable for this method.
    Type: Grant
    Filed: August 18, 2000
    Date of Patent: June 12, 2007
    Assignee: Institut Pasteur
    Inventors: Wilhelm Tischer, Hans-Georg Ihlenfeldt, Octavian Barzu, Hiroshi Sakamoto, Elisabeth Pistotnik, Philippe Marlière, Sylvie Pochet
  • Mutants of desoxycytidine kinase having extended enzymatic activity
    Publication number: 20070037269
    Abstract: The invention relates to a method for artificial in vivo evolution of proteins, said method making it possible to bring about the evolution of a protein X by complementation of a relative protein Y,X and Y both belonging to the same class of enzyme commission (EC) nomenclature or belonging to related classes. The mutants D133E and R104Q of desoxycytidine kinase (DCK) were obtained; both of said mutations result in acquisition of thymidine kinase activity by DCK.
    Type: Application
    Filed: May 19, 2005
    Publication date: February 15, 2007
    Inventors: Philippe Marliere, Sylvie Pochet, Madeleine Bouzon
  • Genomic library of cyanophage s-2l and functional analysis
    Publication number: 20060270005
    Abstract: The invention relates to the genome sequence and the nucleotide sequences coding for polypeptides of cyanophage S-2L. According to the invention, the polypeptides include, but are not limited to, polypeptides involved in the synthesis, transcription and replication of purine bases. In particular, determining the genome of cyanophage S-2L is useful for supplying genes which, expressed in recombinant bacteria, enable the synthesis of DNA monomers incorporating base D (2,6 diaminopurine instead of base A (adenine), thereby producing chemically-remodelled nucleic acids in the bacteria.
    Type: Application
    Filed: April 28, 2003
    Publication date: November 30, 2006
    Applicants: INSTITUT PASTEUR, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, GENOSCOPE- CENTRE NATIONAL DE SEQUENCAGE
    Inventors: Philippe Marliere, Pierre-Alexandre Kaminski, Frederique Galisson, Madaleine Bouzon, Sylvie Pochet, Jean Weissenbach, William Saurin, Catherine Robert, Virginie VIco
  • Combinatorial production of nucleotide and nucleoside(xitp)analogues
    Publication number: 20040023240
    Abstract: The invention concerns novel nucleotide analogues comprising a reactive hydrazide function used as initial synthons for preparing compounds (formula I) capable of inducing mutations or capable of inhibiting a DNA polymerase or a kinase. The invention also concerns nucleic acids comprising said nucleotide and nucleoside analogues. Among such compounds, can be cited in particular the compound of formula (I).
    Type: Application
    Filed: June 18, 2003
    Publication date: February 5, 2004
    Inventors: Philippe Marliere, Sylvie Pochet