Abstract: A method for determining agglutination of a biological liquid by measuring a change in hydrodynamic resistance of the biological liquid flowing through a microfluidic channel of a microfluidic device, comprising the steps of: a) calibrating the microfluidic device; b) filling the microfluidic reaction channel with a hydrophobic continuous liquid phase, c) introducing a first reference droplet; d) causing the first reference droplet to flow; e) measuring the time of flow of the first reference droplet; f) introducing a second reference droplet followed by a sequence of test droplet(s); g) causing the second reference droplet and the sequence of test droplet(s) to flow; h) measuring the time of flow; i) calculating the hydrodynamic resistance of the sequence of the test droplet(s); and j) determining agglutination of the biological liquid by comparing the hydrodynamic resistance with the calibrated values.

Abstract: A method for determining agglutination of a biological liquid by measuring a change in hydrodynamic resistance of the biological liquid flowing through a microfluidic channel of a microfluidic device, comprising the steps of: a) calibrating the microfluidic device; b) filling the microfluidic reaction channel with a hydrophobic continuous liquid phase, c) introducing a first reference droplet; d) causing the first reference droplet to flow; e) measuring the time of flow of the first reference droplet; f) introducing a second reference droplet followed by a sequence of test droplet(s); g) causing the second reference droplet and the sequence of test droplet(s) to flow; h) measuring the time of flow; i) calculating the hydrodynamic resistance of the sequence of the test droplet(s); and j) determining agglutination of the biological liquid by comparing the hydrodynamic resistance with the calibrated values.

Abstract: The invention relates to a system (1) for supplying a microfluidic subsystem with liquids, comprising a first valve (14, 29, 46) and a first fluidic duct (10, 25, 28), for connecting said first valve (14, 29, 46) with said microfluidic subsystem and supplying a first liquid, and a second fluidic duct (11), for connecting with said microfluidic subsystem and supplying a second liquid characterized in that said first valve (14, 29, 46) is suitable for closing with time resolution not worse than 100 msec, and parameters of said first fluidic duct (10, 15, 28) are chosen such that the value of X1[Pa?1], defined as: X1[Pa?1]=(0.

Abstract: The invention relates to a system (1) for supplying a microfluidic subsystem with liquids, comprising a first valve (14, 29, 46) and a first fluidic duct (10, 25, 28), for connecting said first valve (14, 29, 46) with said microfluidic subsystem and supplying a first liquid, and a second fluidic duct (11), for connecting with said microfluidic subsystem and supplying a second liquid characterized in that said first valve (14, 29, 46) is suitable for closing with time resolution not worse than 100 msec, and parameters of said first fluidic duct (10, 15, 28) are chosen such that the value of X1[Pa?1], defined as: X1[Pa?1]=(0.