Patents by Inventor Synèse Jolidon

Synèse Jolidon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups
    Publication number: 20070219207
    Abstract: The present invention relates to compounds of the general formula IC wherein R2, R?, R?, R3, R6, X1 and X1? are as defined herein and pharmaceutically active acid addition salts thereof. Compounds of the invention are useful for the treatment of neurological and neuropsychiatric disorders.
    Type: Application
    Filed: May 21, 2007
    Publication date: September 20, 2007
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • 4-Amino-1,5-substituted-1,5-dihydro-imidazol-2-ones
    Publication number: 20070213384
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, and R4 are as defined herein and to pharmaceutically acceptable acid addition salts thereof. Compounds of formula I or their tautomeric forms are good inhibitors of the glycine transporter 1 (GlyT-1), and have a good selectivity to glycine transporter 2 (GlyT-2) inhibitors. Such compounds are useful for the treatment of schizophrenia.
    Type: Application
    Filed: March 1, 2007
    Publication date: September 13, 2007
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Diaza-spiropiperidine derivatives
    Patent number: 7265126
    Abstract: The present invention relates to compounds of formula wherein A-B, R1, R2, R3, R4, and n are as defined herein; and to pharmaceutically acceptable salts thereof. The compounds of formula I may be used in the treatment of neurological and neuropsychiatric disorders.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: September 4, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Emmanuel Pinard, Andrew William Thomas
  • Benzyloxy derivatives as MAOB inhibitors
    Patent number: 7253318
    Abstract: The invention relates to compounds of the formula and their pharmaceutically acceptable salts wherein R1, R2, R3, R4, R5, n, m, and o are as defined in the specification. The compounds are selective monoamine oxidase ? inhibitors and are useful for the treatment and prevention of Alzheimer's disease and senile dementia, as well as other CNS disorders. The invention also relates to processes for preparing such compounds and pharmaceutical compositions containing them.
    Type: Grant
    Filed: June 20, 2005
    Date of Patent: August 7, 2007
    Assignee: Hoffman-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
  • Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups
    Patent number: 7241761
    Abstract: The present invention relates to compounds of the general formula I wherein R1 is the group and R2, R?, R?, R3, R4, R5, R6, R7, X1, X1?, X2, and N are as defined in the specification. Compounds of the invention are useful for the treatment of neurological and neuropsychiatric disorders.
    Type: Grant
    Filed: December 1, 2005
    Date of Patent: July 10, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Robert Narquizian, Roger David Norcross, Emmanuel Pinard
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7235581
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, e.g. which are mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: June 26, 2007
    Assignee: Hoffman-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
  • Bicyclic compounds
    Publication number: 20070117791
    Abstract: The present invention relates to methods for making and using novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X?, Y and Y? are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.
    Type: Application
    Filed: January 12, 2007
    Publication date: May 24, 2007
    Inventors: Synese Jolidon, Rosa Rodriguez Sarmiento, Andrew Thomas, Wolfgang Wostl, Rene Wyler
  • Monocyclic substituted phenyl methanones
    Patent number: 7220744
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, X1, and X2 are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. Such compounds are inhibitors of the glycine transporter 1 (GlyT-1) and can be used in the treatment of schizophrenia, cognitive impairment, and Alzheimer's disease.
    Type: Grant
    Filed: January 3, 2006
    Date of Patent: May 22, 2007
    Assignee: Hoffman-La Roche Inc.
    Inventors: Synese Jolidon, Robert Narquizian, Roger David Norcross, Emmanuel Pinard
  • Bicyclic compounds
    Patent number: 7173023
    Abstract: The present invention relates to novel benzazepine derivatives of the following formula: wherein R1, R2, R3, R4 and R5, X, X?, Y and Y? are as defined in the description and claims, processes for their preparation, pharmaceutical compositions containing said derivatives and their use for the preparation of medicaments useful for the prevention and treatment of diseases in which selective inhibition of monoamine oxidase B activity plays a role or is implicated.
    Type: Grant
    Filed: October 18, 2004
    Date of Patent: February 6, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Synese Jolidon, Rosa Maria Rodriguez Sarmiento, Andrew William Thomas, Wolfgang Wostl, Rene Wyler
  • Diaza-spiropiperidine derivatives
    Patent number: 7173133
    Abstract: The present invention relates to compounds of formula wherein A-B is —CH2—CH2—, —CH2—O— or —O—CH2—; X is hydrogen or hydroxy; R1 is aryl, optionally substituted by one or two substituents selected from the group consisting of halogen, lower alkyl, cyano, CF3, —OCF3, lower alkoxy, —SO2-lower alkyl and heteroaryl; R2 is aryl, optionally substituted by one or two substituents selected from the group consisting of halogen, lower alkyl, CF3, and lower alkoxy; R3 is hydrogen or lower alkyl; n is 0, 1 or 2; or a pharmaceutically active salt thereof. The compounds of the invention may be used in the treatment of neurological and neuropsychiatric disorders.
    Type: Grant
    Filed: January 3, 2005
    Date of Patent: February 6, 2007
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Simona Maria Ceccarelli, Synese Jolidon, Emmanuel Pinard, Andrew William Thomas
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7151111
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of a disease which is mediated by a monoamine oxidase B inhibitor, in particular Alzheimer's disease and senile dementia.
    Type: Grant
    Filed: September 18, 2003
    Date of Patent: December 19, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Iding, Synese Jolidon, Daniela Krummenacher, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Beat Wirz, Wolfgang Wostl, Rene Wyler
  • 4-pyrrolidino-phenyl-benzyl ether derivatives
    Patent number: 7122562
    Abstract: The invention relates to racemic or enantiomerically pure 4-pyrrolidino derivatives, processes for their preparation, pharmaceutical compositions comprising said derivatives, and their use in the prevention and treatment of illness, in particular which is mediated by monoamine oxidase B inhibitors, in particular Alzheimer's disease or senile dementia.
    Type: Grant
    Filed: January 5, 2006
    Date of Patent: October 17, 2006
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Hans Iding, Synese Jolidon, Daniela Krummenacher, Rosa Maria Rodriguez-Sarmiento, Andrew William Thomas, Beat Wirz, Wolfgang Wostl, Rene Wyler
  • Heterocyclic-substituted phenyl methanones
    Publication number: 20060178381
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, and are defined in the specification and to pharmaceutically acceptable acid addition salts thereof.
    Type: Application
    Filed: January 31, 2006
    Publication date: August 10, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Substituted phenyl methanones
    Publication number: 20060167023
    Abstract: The present invention relates to compounds of general formula IA or IB wherein X1 and X2 are each independently N or C—R? and R1, R2,R3, R4, R5, and R6 are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. The compounds can be used for the treatment of diseases related to the glycine transporter inhibitor, such as schizophrenia and Alzheimer's disease.
    Type: Application
    Filed: January 24, 2006
    Publication date: July 27, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Monocyclic substituted phenyl methanones
    Publication number: 20060167009
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, X1, and X2 are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. Such compounds are inhibitors of the glycine transporter 1 (GlyT-1) and can be used in the treatment of schizophrenia, cognitive impairment, and Alzheimer's disease.
    Type: Application
    Filed: January 3, 2006
    Publication date: July 27, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Substituted phenyl methanone derivatives
    Publication number: 20060160788
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, n, and m, are as defined in the specification and to pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) and are useful for the treatment of CNS disorders such as schizophrenia, cognitive impairment, and Alzheimer's disease.
    Type: Application
    Filed: January 17, 2006
    Publication date: July 20, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Benzoyl-tetrahydropiperidine derivatives
    Publication number: 20060148797
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, and Ar; are as defined in the specification. The invention also provides pharmaceutically acceptable acid addition salts thereof and methods for the treatment of neurological and neuropsychiatric disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.
    Type: Application
    Filed: December 13, 2005
    Publication date: July 6, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Sulfanyl substituted phenyl methanones
    Publication number: 20060149062
    Abstract: The present invention relates to compounds of formula I wherein R1, R2, R3, X, X1, and n are as defined in the specification and pharmaceutically acceptable acid addition salts thereof. These compounds are good inhibitors of the glycine transporter 1 (GlyT-1) for the treatment CNS disorders, such as schizophrenia, cognitive impairment, and Alzheimer's disease.
    Type: Application
    Filed: January 3, 2006
    Publication date: July 6, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Phenyl-piperazine methanone derivatives, substituted by heterocyclic groups
    Publication number: 20060128712
    Abstract: The present invention relates to compounds of the general formula I wherein R1 is the group and R2, R?, R?, R3, R4, R5, R6, R7, X1, X1?, X2, and N are as defined in the specification. Compounds of the invention are useful for the treatment of neurological and neuropsychiatric disorders.
    Type: Application
    Filed: December 1, 2005
    Publication date: June 15, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard
  • Bi- and tricyclic substituted phenyl methanones
    Publication number: 20060128713
    Abstract: The present invention relates to compounds of the general formula I and R1, R?,; R?, R2, R3, R4, R5, R6, R7, m and n are as defined in the specification, and to pharmaceutically active acid addition salts thereof. The compounds of the invention are useful in the treatment of neurological and neuropsychiatric disorders.
    Type: Application
    Filed: December 8, 2005
    Publication date: June 15, 2006
    Inventors: Synese Jolidon, Robert Narquizian, Roger Norcross, Emmanuel Pinard