Abstract: Provided is a pulse wave propagation detection system including an electrocardiographic signal detection unit, and an eyeground image detection unit for detecting an eyeground image in synchronization with an electrocardiographic signal detected through the detection unit, which system further includes a correlation unit for correlating a change in the diameter of an eyeground vein—which diameter is measured, at the optic papilla, by use of an eyeground image synchronized with an arbitrary electrocardiographic signal—with the state of pulse wave propagation through an intracerebral blood vessel or with the state of sclerosis of a capillary artery.

Abstract: Provided is a pulse wave propagation detection system including electrocardiographic signal detection means, and eyeground image detection means for detecting an eyeground image in synchronization with an electrocardiographic signal detected through the detection means, which system further includes means for correlating a change in the diameter of an eyeground vein—which diameter is measured, at the optic papilla, by use of an eyeground image synchronized with an arbitrary electrocardiographic signal—with the state of pulse wave propagation through an intracerebral blood vessel or with the state of sclerosis of a capillary artery. Provision of the pulse wave propagation detection system; i.e., means for conveniently and accurately identifying the state of blood flow in the brain or the state of sclerosis of a capillary artery, enables prevention of adverse effects of, for example, excessive drop in blood pressure.

Abstract: An arteriosclerosis detection system including an electrocardiographic signal detection device, an eyeground image detection device for detecting an eyeground image in synchronization with an electrocardiographic signal detected by the detection device. The arteriosclerosis detection system further includes an eyeground vein constriction detection device for detecting the constriction of an eyeground vein in the vicinity of a site at which the eyeground vein and an eyeground artery cross each other. The constriction is detected based on the detected eyeground image in synchronization with the electrocardiographic signal. The arteriosclerosis detection system detects the eyeground image by executing an algorithm of software, which provides an eyeground image synchronized with an electrocardiographic signal by obtaining a stationary eyeground image synchronized with an arbitrary electrocardiographic signal from an animated eyeground image.

Abstract: An object of the present invention is to provide a method of identifying a substance which acts on a newly found second human prostaglandin D2 receptor subtype that differs from the DP receptor, and is useful for treating or preventing various diseases. In order to attain the object, the present invention provides a method of identifying properties of a test substance with respect to a human prostaglandin D receptor, by establishing correlation between the effect of a test substance on human CRTH2 with the effect of the test substance on the human prostaglandin D receptor.

Abstract: The invention is drawn to detect arteriosclerosis by convenient and sensitive means. The present inventors have found that such means can be obtained by use of an arteriosclerosis detection system including electrocardiographic signal detection means, eyeground image detection means for detecting an eyeground image in synchronization with an electrocardiographic signal detected by the detection means, and eyeground vein constriction detection means for detecting the constriction of an eyeground vein in the vicinity of a site at which the eyeground vein and an eyeground artery cross each other, on the basis of the eyeground image detected in synchronization with the electrocardiographic signal.

Abstract: The present specification provides a means for specifying the condition and type of immune-related diseases on the basis of knowledge about the polarization of the distribution of helper T-cell subsets Th1 and Th2. More specifically, the gene (B19), specific only to the human Th2, is prepared by a subtraction method. A human-Th2-specific protein which the gene encodes is produced by recombinant methods, and a monoclonal antibody against the Th2-specific protein and a hybridoma which produces the monoclonal antibody is provided.

Abstract: The present invention provides for specifying the condition and type of immune-related diseases on the basis of the knowledge about the polarization of the distribution of helper T-cell subsets Th1 and Th2. More sepcifically, in this invention, the gene (B19) specific only the human Th2 is prepared and specified by a subtraction method, and a recombinant vector into which the gene is incorporated, a transformant transformed by the recombinant vector, a human-Th2-specific protein which the gene encodes and which derives from the transformant, and a monoclonal antibody against the Th2-specific protein are produced and the gene, protein, antibody, etc. are used as the means for specifying or correcting the polarization of the distribution of Th1 and Th2 to solve the above object.