Patents by Inventor Syoji Handa

Syoji Handa has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR PRODUCING FUSED IMIDAZOLE COMPOUND, REFORMATSKY REAGENT IN STABLE FORM, AND PROCESS FOR PRODUCING THE SAME
    Publication number: 20100105922
    Abstract: The present invention provides an industrially advantageous process for producing a steroid C17,20 lyase inhibitor represented by the general formula (I); and a Reformatsky reagent in a stable form suitable for the process. In the present invention, a compound represented by the general formula (I) is produced by reducing a specific ?-hydroxy ester compound derivative or a salt thereof obtained from a specific carbonyl compound in a Reformatsky reaction in the presence of a metal hydride complex and a metal halide, and then subjecting it to a ring-closing reaction. In the above Reformatsky reaction, it is useful to use a stable solution of a compound represented by the general formula BrZnCH2COOC2H5 or a crystal of the compound which is represented by the formula (BrZnCH2COOC2H5.THF)2.
    Type: Application
    Filed: December 28, 2009
    Publication date: April 29, 2010
    Applicant: Takeda Pharmaceutical Company Limited
    Inventors: Jun-Ichi Kawakami, Koji Nakamoto, Shigeru Nuwa, Syoji Handa, Shokyo Miki
  • Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same
    Patent number: 7662974
    Abstract: The present invention provides an industrially advantageous process for producing a steroid C17,20 lyase inhibitor represented by the general formula (I): and a Reformatsky reagent in a stable form suitable for the process. In the present invention, a compound represented by the general formula (I) is produced by reducing a specific ?-hydroxy ester compound derivative or a salt thereof obtained from a specific carbonyl compound in a Reformatsky reaction in the presence of a metal hydride complex and a metal halide, and then subjecting it to a ring-closing reaction. In the above Reformatsky reaction, it is useful to use a stable solution of a compound represented by the general formula BrZnCH2COOC2H5 or a crystal of the compound which is represented by the formula (BrZnCH2COOC2H5.THF)2.
    Type: Grant
    Filed: January 9, 2003
    Date of Patent: February 16, 2010
    Assignee: Takeda Pharmaceutical Company Limited
    Inventors: Jun-ichi Kawakami, Koji Nakamoto, Shigeru Nuwa, Syoji Handa, Shokyo Miki
  • Process for producing fused imidazole compound, reformatsky reagent in stable form, and process for producing the same
    Publication number: 20050043544
    Abstract: The present invention provides an industrially advantageous process for producing a steroid C17,20 lyase inhibitor represented by the general formula (I): and a Reformatsky reagent in a stable form suitable for the process. In the present invention, a compound represented by the general formula (I) is produced by reducing a specific ?-hydroxy ester compound derivative or a salt thereof obtained from a specific carbonyl compound in a Reformatsky reaction in the presence of a metal hydride complex and a metal halide, and then subjecting it to a ring-closing reaction. In the above Reformatsky reaction, it is useful to use a stable solution of a compound represented by the general formula BrZnCH2COOC2H5 or a crystal of the compound which is represented by the formula (BrZnCH2COOC2H5.THF)2.
    Type: Application
    Filed: January 9, 2003
    Publication date: February 24, 2005
    Inventors: Shigeru Nuwa, Syoji Handa, Shokyo Miki