Abstract: An immunoglobulin composition comprising an immunoglobulin, and as an aggregation preventing agent or an aggregate dissociating agent for the immunoglobulin, about 1 to about 600% by weight, based on the weight of the immunoglobulin, of a water-soluble acid additive salt of a basic nitrogen-containing organic compound containing one or more basic nitrogen atoms in the molecule and optionally carboxyl groups in smaller number than the basic nitrogen atoms and having a pKb at 25.degree. C.

Abstract: The present invention is directed to an S-sulfonated immunoglobulin composition comprising an S-sulfonated immunoglobulin and as an aggregation preventing agent or an aggregate dissociating agent, therefor, about 1 to about 600% by weight, based on the weight of the S-sulfonated immunoglobulin, of a water-soluble acid addition salt of a basic nitrogen-containing organic compound containing one or more basic nitrogen atoms in the molecule and optionally carboxyl groups smaller in number than the basic nitrogen atoms and having a pKb at 25.degree. C. of not more than 7.

Abstract: A process for the preparation of immunogammaglobulin derivatives that can be administered by intravenous injection because of their reduced anticomplement activity level in which the reaction of human immunogammaglobulin with a compound capable of forming trithionate ion and another compound capable of forming sulfite ion in water is carried out in water to cleave the interchain disulfide bonds in said immunogammaglobulin and simultaneously the sulfur atoms cleaved are S-sulfonated.

Abstract: This invention provides novel penicillin derivatives of formula [I]; ##STR1## wherein A is hydrogen or hydroxyl, and B represents the cumarin nucleus of formula [III-a]; ##STR2## in which B.sub.1, B.sub.2, B.sub.3, B.sub.4 and B.sub.5 are same or different, and are hydrogen or substituent groups that may contain nitrogen, sulfur or oxygen atom,or nontoxic salts thereof, and bactericides containing said novel penicillin derivatives or nontoxic salts thereof as the main ingredient, and also an advantageous process for producing said novel penicillin derivatives or nontoxic salts thereof, which comprises reacting a derivative of .alpha.-aminobenzylpenicillin with a coumarincarboxylic acid or reacting 6-aminopencillanic acid, a carboxylic acid salt thereof or a protected derivative thereof having the carboxyl blocked with a readily removable protecting group, with a coumarincarboxylic acid phenylglycinamide.