Patents by Inventor Syuichi Oka
Syuichi Oka has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8697369Abstract: Using betaKlotho or a substance that increases or inhibits betaKlotho activity as an agent for controlling the activity of FGF21 mediated by an FGF receptor, the present invention provides a pharmaceutical composition comprising such betaKlotho or such substance as an active ingredient, particularly, a pharmaceutical composition for anti-metabolic syndrome, and further particularly, a pharmaceutical composition for therapeutic or preventive use associated with the control of blood glucose level. In addition, the present invention provides a screening system for each of a substance that enhances or suppresses betaKlotho activity, an FGF21-like active substance, and a betaKlotho-like active substance, which uses a cell system that has expressed an FGF receptor and/or betaKlotho on the surface thereof.Type: GrantFiled: April 7, 2008Date of Patent: April 15, 2014Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Masashi Suzuki, Toru Imamura, Yuriko Uehara, Kaori Motomura, Junko Oki, Syuichi Oka, Masahiro Asada, Akiko Kuramochi, Miho Kimura
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Patent number: 8304393Abstract: It is intended to provide a novel oligopeptide which can be relatively easily produced, has not only a hair growth-stimulating effect but also an effect of promoting the growth of epithelial cells (for example, skin regeneration) and can easily pass through the horny layer to thereby reach the desired target cells in which its effects are to be exerted. Namely, water-soluble oligopeptides containing a proryl isoleucyl glycyl unit or an isoleucyl glycyl serine unit and having from 3 to 7 amino acids and water-soluble salts thereof.Type: GrantFiled: May 3, 2010Date of Patent: November 6, 2012Assignee: Patent Technology Development Inc.Inventors: Syuichi Oka, Akinori Tsuruda, Yasuhiro Kawano, Mitsuo Suzuki, Satoshi Nakazato
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Publication number: 20120251455Abstract: A hair removing agent or a hair growth inhibiting agent is provided by determining an endogenous factor having a hair growth inhibitory activity, screening for substances having an activity similar to that of the endogenous factor or substances enhancing the activity or expression of the endogenous factor, and utilizing the physiological activities of such substances. It has been found that FGF18 inhibits hair growth. A method of screening for FGF18-like active substances, substances that promote the activity of FGF18 or substances that promote the expression of FGF18 to thereby obtain candidates for the hair growth inhibiting agent or hair removing agent is disclosed. Also disclosed is a hair growth inhibiting agent or a hair removing agent comprising, as an active ingredient, FGF18 and/or an FGF18 partial peptide, or an FGF18-like active substance and/or a substance that promotes the activity or expression of FGF18 (e.g., Digenea simplex extract).Type: ApplicationFiled: January 27, 2012Publication date: October 4, 2012Applicant: NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGYInventors: Toru IMAMURA, Miho KIMURA, Mitsuko KAWANO, Nozomi TSUJINO, Akiko KURAMOCHI, Yuko ODA, Kaori MOTOMURA, Masashi SUZUKI, Masahiro ASADA, Azusa KAMEYAMA, Sumie TOGAYACHI, Syuichi OKA
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Publication number: 20100298235Abstract: It is intended to provide a novel oligopeptide which can be relatively easily produced, has not only a hair growth-stimulating effect but also an effect of promoting the growth of epithelial cells (for example, skin regeneration) and can easily pass through the horny layer to thereby reach the desired target cells in which its effects are to be exerted. Namely, water-soluble oligopeptides containing a proryl isoleucyl glycyl unit or an isoleucyl glycyl serine unit and having from 3 to 7 amino acids and water-soluble salts thereof.Type: ApplicationFiled: May 3, 2010Publication date: November 25, 2010Inventors: Syuichi Oka, Akinori Tsuruda, Yasuhiro Kawano, Mitsuo Suzuki, Satoshi Nakazato
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Patent number: 7820625Abstract: At least one substance selected from the group consisting of a water-soluble peptide comprising at least one unit selected from the group consisting of an isoleucylglycylseryl unit, a prolylisoleucylglycylseryl [SEQ ID NO: 2] unit, a glycylprolylisoleucylglycylseryl [SEQ ID NO: 6] unit, a glycylprolylisoleucylglycylthreonyl [SEQ ID NO: 7] unit, a prolylisoleucylglycyl unit and a glycylprolylisoleucylglycyl [SEQ ID NO: 1] unit and a water-soluble salt thereof can be used as an UV-induced dermatitis inhibitor or atopic dermatitis inhibitor.Type: GrantFiled: March 27, 2006Date of Patent: October 26, 2010Assignee: National Institute of Advanced Industrial Science and TechnologyInventors: Syuichi Oka, Akinori Tsuruda
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Publication number: 20100203055Abstract: It is intended to provide a hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia by determining an endogenous factor that inhibits hair growth and screening for substances that inhibit the activity or expression of the endogenous factor. It has been found that FGF18 inhibits hair growth. A method of screening for substances that inhibit the activity of FGF18 or substances that inhibit the expression of FGF18 to thereby obtain candidates for the hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia is disclosed. Also disclosed is a hair growth promoting agent, hair regrowth promoting agent or therapeutic for alopecia comprising, as an active ingredient(s), a substance that inhibit the activity of FGF18 and/or a substance that inhibits the expression of FGF18 such as a partial peptide of FGF18 or a Momordica charantia hot water extract.Type: ApplicationFiled: February 19, 2008Publication date: August 12, 2010Inventors: Toru Imamura, Miho Kimura, Mitsuko Kawano, Nozomi Tsujino, Akiko Kuramochi, Yuko Oda, Kaori Motomura, Masashi Suzuki, Masahiro Asada, Azusa Kameyama, Sumie Togayachi, Syuichi Oka
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Publication number: 20100184665Abstract: Using betaKlotho or a substance that increases or inhibits betaKlotho activity as an agent for controlling the activity of FGF21 mediated by an FGF receptor, the present invention provides a pharmaceutical composition comprising such betaKlotho or such substance as an active ingredient, particularly, a pharmaceutical composition for anti-metabolic syndrome, and further particularly, a pharmaceutical composition for therapeutic or preventive use associated with the control of blood glucose level. In addition, the present invention provides a screening system for each of a substance that enhances or suppresses betaKlotho activity, an FGF21-like active substance, and a betaKlotho-like active substance, which uses a cell system that has expressed an FGF receptor and/or betaKlotho on the surface thereof.Type: ApplicationFiled: April 7, 2008Publication date: July 22, 2010Inventors: Masashi Suzuki, Toru Imamura, Yuriko Uehara, Kaori Motomura, Junko Oki, Syuichi Oka, Masahiro Asada, Akiko Kuramochi, Miho Kimura
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Publication number: 20100183733Abstract: A hair removing agent or a hair growth inhibiting agent is provided by determining an endogenous factor having a hair growth inhibitory activity, screening for substances having an activity similar to that of the endogenous factor or substances enhancing the activity or expression of the endogenous factor, and utilizing the physiological activities of such substances. It has been found that FGF18 inhibits hair growth. A method of screening for FGF18-like active substances, substances that promote the activity of FGF18 or substances that promote the expression of FGF18 to thereby obtain candidates for the hair growth inhibiting agent or hair removing agent is disclosed. Also disclosed is a hair growth inhibiting agent or a hair removing agent comprising, as an active ingredient, FGF18 and/or an FGF18 partial peptide, or an FGF18-like active substance and/or a substance that promotes the activity or expression of FGF18 (e.g., Digenea simplex extract).Type: ApplicationFiled: February 19, 2008Publication date: July 22, 2010Inventors: Toru Imamura, Miho Kimura, Mitsuko Kawano, Nazomi Tsujino, Akiko Kuramochi, Yuko Oda, Kaori Motomura, Masashi Suzuki, Masahiro Asada, Azusa Kameyama, Sumie Togayachi, Syuichi Oka
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Patent number: 7750115Abstract: It is intended to provide a novel oligopeptide which can be relatively easily produced, has not only a hair growth-stimulating effect but also an effect of promoting the growth of epithelial cells (for example, skin regeneration) and can easily pass through the horny layer to thereby reach the desired target cells in which its effects are to be exerted. Namely, water-soluble oligopeptides containing a proryl isoleucyl glycyl unit or an isoleucyl glycyl serine unit and having from 3 to 7 amino acids and water-soluble salts thereof.Type: GrantFiled: March 28, 2005Date of Patent: July 6, 2010Assignee: Patent Technology Development, Inc.Inventors: Syuichi Oka, Akinori Tsuruda, Yasuhiro Kawano, Mitsuo Suzuki, Satoshi Nakazato
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Publication number: 20090215702Abstract: At least one substance selected from the group consisting of a water-soluble peptide comprising at least one unit selected from the group consisting of an isoleucylglycylseryl unit, a prolylisoleucylglycylseryl unit, a glycylprolylisoleucylseryl unit, a glycylprolylisoleucylglycylthreonyl unit, a prolylisoleucylglycyl unit and a glycylprolylisoleucylglycyl unit and a water-soluble salt thereof can be used as an UV-induced dermatitis inhibitor or atopic dermatitis inhibitor.Type: ApplicationFiled: March 27, 2006Publication date: August 27, 2009Inventors: Syuichi Oka, Akinori Tsuruda
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Patent number: 7282481Abstract: A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method of functionalizing a natural protein having no sugar chain by covalently bonding thereto a sugar chain.Type: GrantFiled: November 23, 2005Date of Patent: October 16, 2007Assignee: Director-General of Agency of Industrial Science and TechnologyInventors: Toru Imamura, Masahiro Asada, Syuichi Oka, Masashi Suzuki, Atsuko Yoneda, Keiko Ota, Yuko Oda, Kazuko Miyakawa, Noriko Orikasa, Chie Asada, Tetsuhito Kojima
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Publication number: 20070213276Abstract: It is intended to provide a novel oligopeptide which can be relatively easily produced, has not only a hair growth-stimulating effect but also an effect of promoting the growth of epithelial cells (for example, skin regeneration) and can easily pass through the horny layer to thereby reach the desired target cells in which its effects are to be exerted. Namely, water-soluble oligopeptides containing a proryl isoleucyl glycyl unit or an isoleucyl glycyl serine unit and having from 3 to 7 amino acids and water-soluble salts thereof.Type: ApplicationFiled: March 28, 2005Publication date: September 13, 2007Inventors: Syuichi Oka, Akinori Tsuruda, Yasuhiro Kawano, Mitsuo Suzuki, Satoshi Nakazato
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Publication number: 20060121136Abstract: Disclosed is a hypotensive agent that is safe and inexpensive. The agent contains an oligosaccharide that comprises at least one type of hexose and has at least one 1-6 bond.Type: ApplicationFiled: October 28, 2004Publication date: June 8, 2006Applicant: National Institute of Advanced Industrial Science and TechnologyInventors: Syuichi Oka, Akinori Tsuruda, Yasuhiro Kawano, Susumu Maruyama, Yoshimitsu Yamazaki, Miyuki Kikuchi, Hideaki Ono
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Publication number: 20060079451Abstract: A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method of functionalizing a natural protein having no sugar chain by covalently bonding thereto a sugar chain.Type: ApplicationFiled: November 23, 2005Publication date: April 13, 2006Applicant: Director-General of Agency of Industrial Science and TechnologyInventors: Toru Imamura, Masahiro Asada, Syuichi Oka, Masashi Suzuki, Atsuko Yoneda, Keiko Ota, Yuko Oda, Kazuko Miyakawa, Noriko Orikasa, Chie Asada, Tetsuhito Kojima
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Patent number: 7005415Abstract: A heparin-binding protein functionalized by covalently bonding thereto a sugar chain, a method for producing the protein and a pharmaceutical composition containing the protein as an active ingredient, as well as a method for functionalizing a natural protein having no sugar chain by covalently bonding thereto a sugar chain.Type: GrantFiled: July 22, 1998Date of Patent: February 28, 2006Assignee: Director-General Agency of Industrial Science and TechnologyInventors: Toru Imamura, Masahiro Asada, Syuichi Oka, Masashi Suzuki, Atsuko Yoneda, Keiko Ota, Yuko Oda, Kazuko Miyakawa, Noriko Orikasa, Chie Asada, Tetsuhito Kojima
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Patent number: 6740521Abstract: The present invention provides a bioassay system, for detection of hazardous chemical substances, natural toxic substances in the environment and unknown toxic compounds, with high sensitivity, simplicity and speed. The invention provides cells and a method of using the cells for use in the bioassay system. The cell provided by the invention contains a heat shock factor binding DNA sequence and a transcriptional regulatory sequence necessary on an occasion of stress induction as a transcriptional regulatory factor binding site. The cell also possesses a reporter gene under the control of the promoter. The reporter gene is connected, on the downstream side, to the SV40pA signal without any intervening intron.Type: GrantFiled: March 11, 2002Date of Patent: May 25, 2004Assignees: Kaneka Corporation, Agency of Industrial Science and Technology, Ministry of International Trade and IndustryInventors: Hiroko Isoda, Takashi Koyama, Masako Tasaki, Syuichi Oka, Norio Sugiura, Takaaki Maekawa, Yuhei Inamori, Shinichi Yokota, Mikio Kitahara, Kazuhiro Nagata
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Publication number: 20030049737Abstract: The present invention is aimed to provide a bioassay system that can detect hazardous chemical substances or natural toxic substances in the environment, inclusive of the unknown homologs, with high sensitivity, simplicity and speed.Type: ApplicationFiled: March 11, 2002Publication date: March 13, 2003Applicant: KANEKA CORPORATION AND THE NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY (AIST),Inventors: Hiroko Isoda, Takashi Koyama, Masako Tasaki, Syuichi Oka, Norio Sugiura, Takaaki Maekawa, Yuhei Inamori, Shinichi Yokota, Mikio Kitahara, Kazuhiro Nagata
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Patent number: 5874254Abstract: The present invention relates to a novel FGF-5 analogous protein derived from mature mRNA formed by directly binding exon 1 to exon 3 in the splicing of a gene coding for FGF-5 protein as well as to a pharmaceutical composition containing the same as an active ingredient. The pharmaceutical composition containing the novel FGF-5 analogous protein of the present invention as an active ingredient can regulate physiological functions of FGF-5, such as regulation of restoration or development of hairs on the head and body, regulation of trophic and functional regulation in the brain and nervous system, proliferation of fibroblasts, etc.Type: GrantFiled: March 19, 1997Date of Patent: February 23, 1999Assignee: Director-General of Agency of Industrial Science and TechnologyInventors: Toru Imamura, Syuichi Oka, Kazuo Ozawa, Chieri Sato, Seigo Suzuki