Abstract: A device is provided for applying flexible fasteners to tissue to close a wound or incision. The device has a front housing mounted for rotation relative to a rear housing. A needle projects laterally from the front housing. The needle is curved, hollow, and slotted for receiving a portion of a fastener. The device has a flexible pusher member and means for moving the flexible pusher member into the hollow needle to eject a fastener from the needle and into the tissue.

Abstract: An actuating mechanism is provided for a hand-operated surgical instrument having at least one operating member. The operating member is engaged by or extends from a flexible pusher member wound at least partially around the circumference of a drum and secured thereto. A pinion is connected to the drum for rotation therewith and is driven by a gear segment on a handle that is pivotally monted to the instrument. A full stroke compelling mechanism is associated with the drum for preventing return of the handle to the unactuated position unless and until the operating member has been moved through the full design range of movement.