Abstract: The invention relates to new aminoethoxybenzylalcohol derivatives of the formula (I) ##STR1## wherein R.sub.1 is hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms;R.sub.2 is halogen, trihalomethyl, or alkoxy having from one to 4 carbon atoms;R.sub.3 and R.sub.4 stand for methyl or together with the adjacent nitrogen form an up to 8-membered ring optionally containing oxygen,and acid addition or quaternary ammonium salts thereof.The compounds of formula (I) are pharmacologically active, thus show enzyme-inducing effect. The pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

Abstract: The invention relates to new 1,1-diphenylpropan-1-ol derivatives of the formula (I) ##STR1## wherein R.sub.1 and R.sub.2 independently represent hydrogen, halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms,R.sub.3 is halogen, trihalomethyl, alkyl having from one to 5 carbon atoms or alkoxy having from one to 5 carbon atoms,R.sub.4 is phenyl optionally substituted by one or more identical or different substituents selected from the group of halogen, trihalomethyl, alkyl, alkoxy, cyano, nitro, amino, alkylamino, dialkylamino, hydroxyl, carboxyl or substituted carboxyl; dialkylaminocarbonyl or alkoxycarbonyl containing from one to 4 carbon atoms in the alkyl and alkoxy moieties, respectively,n is 1, 2, 3, 4, or 5.According to another aspect of the invention there are provided processes for the preparation of the compounds of formula (I).

Abstract: The invention relates to new piperidine derivatives of the formula (I) ##STR1## wherein R.sub.1 is halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms; andR.sub.2 is hydrogen or alkyl having from one to 4 carbon atoms, and acid addition and quaternary ammonium salts thereof. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the formula (I) are pharmacologically active. In particular, they inhibit the microsomal monooxigenase enzyme system of the liver. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

Abstract: The invention relates to new benzhydrylpiperazine derivatives of the formula (I) ##STR1## wherein n is 2 or 3, and acid addition salts thereof. According to another aspect of the invention there are provided processes for the preparation of these compounds.The compounds of the formula (I) are pharmacologically active. More particularly, they inhibit the microsomal monooxigenase enzyme system of liver. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.

Abstract: A tranquillo-sedative substituted 1,3,4,5-tetrahydro-2H-1,4-benzodiazepine-2-one of the formula (I), ##STR1## wherein R.sub.1 is halogen or nitro,R.sub.2 is hydrogen or methyl,R.sub.3 is --CONH.sub.2 or --CONHCH.sub.3, andR.sub.6 is phenyl or halophenyl.

Abstract: A tranquillo-sedative substituted 1,3,4,5-tetrahydro-2H-1,4-benzodiazepine-2-one of the formula (I), ##STR1## wherein R.sub.1 is halogen or nitro,R.sub.2 is hydrogen or C.sub.1 to C.sub.6 alkyl,R.sub.3 is --CONH.sub.2, andR.sub.6 is phenyl or halophenyl.

Abstract: Curare-type salts of the formula ##STR1## wherein Ac is an alkyl carbonyl group containing 1 to 4 carbon atoms in the alkyl moiety and one ofR.sub.1 and R.sub.2, is a methylene group and the other is a group of the formula >N--R.sub.2 wherein R.sub.2 is an alkyl group containing 1 to 3 carbon atoms,A is halogen andR.sub.3 is an alkyl group containing 1 to 4 carbon atoms, or an alkyl group; anda process for the preparation thereof are disclosed.

Abstract: The invention relates to new .alpha.

Abstract: New triamino-androstanes with curare-type properties and a process for the preparation thereof are disclosed.

Abstract: .alpha.-ethynyl-benzhydrols, namely 2,5-dimethyl-.alpha.-ethynyl and 4-n-butyl-.alpha.-ethynyl benzhydrol, are made by reacting the starting benzophenone with acetylene in a solvent delivering no protons, in the presence of an alkali metal tertiary alcoholate, preferably potassium-ter.-butylate or potassium-tert.-amylate.

Abstract: A compound of the following formula: ##STR1## wherein X.sub.1 is hydrogen or mercapto;X.sub.2 is mercapto or acetylthio;X.sub.3 is hydrogen or acetylthio; andX.sub.4 is hydrogen, acetylthio or X.sub.3 and X.sub.4 together form a valence bond, but if X.sub.3 and X.sub.4 form a valence bond X.sub.2 is mercapto. The compounds are useful in the treatment of heavy-metal poisoning.

Abstract: An N-substituted carbonyl tetrahydrobenzodiazepines having ethoxycarbonyl, formyl, carbamoyl or methyl carbamoyl as the N.sup.4 substituent.

Abstract: A compound of the formula: ##STR1## wherein Z is ethyl or vinyl,R.sub.1 and R.sub.2 are hydrogen, lower alkyl, lower alkenyl or trihalomethyl,R.sub.3 and R.sub.4 are hydrogen, lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl or phenyl, andR.sub.5 is lower alkyl, lower alkenyl, trihalomethyl, cyclopentyl, benzyl, or phenyl with the proviso that where R.sub.1, R.sub.2, R.sub.3 and R.sub.4 each is hydrogen, R.sub.5 is not methyl attached to the 4-position of the benzene ring, or a pharmaceutically acceptable acid addition or quaternary ammonium salt thereof is disclosed as effective in the regulation of the liver microsomal enzyme system.

Abstract: New benzodiazepine derivatives of the formula (I), ##STR1## wherein R.sub.1 stands for halogen, trifluoromethyl, nitro or amino,R.sub.2 stands for hydrogen or alkyl, andR.sub.3 stands for nitroso, amino, alkylideneamino, substituted alkylideneamino, aralkylideneamino, substituted aralkylideneamino, acylamido or substituted acylamido.The new compounds possess remarkable enzyme-inducing effects and exert only moderate central nervous activities.

Abstract: Pharmaceutically active steroids of the formula (I) ##SPC1##whereinX.sub.1 and X.sub.2 each is hydrogen, mercapto or acetylthio andX.sub.3 and X.sub.4 each is hydrogen or acetylthio orX.sub.3 and X.sub.4 form together a valence bond, with the proviso that at least one of X.sub.1 to X.sub.4 is selected from the group consisting of mercapto and acetylthio. The compounds are prepared as follows: a compound of the formula (III) ##SPC2##wherein Z.sub.1 is hydrogen and Z.sub.2 is hydrogen or acetylthio or Z.sub.1 and Z.sub.2 form together a valence bond, is brominated, the thus-obtained compound of the formula ##SPC3##Wherein Y.sub.1 and Y.sub.2 each is hydrogen or bromine, Y.sub.3 is bromine, Y.sub.4 is hydrogen or acetylthio or Y.sub.3 and Y.sub.4 form together a valence bond, is reacted with an alkali methal thioacetate or with an alkali metal hydrosulphide. Thioacetic acid can be coupled onto the obtained product, and/or optionally the obtained thioacetyl compound can be subjected to alcoholysis.