Abstract: A method of identifying fibrotic agents capable of modulating a fibrotic process or condition is provided, along with compositions containing such compounds. The method involves contacting a plurality of fibroblasts with a test compound and determining whether the compound modulates expression of a gene that inhibits collagen synthesis. Compounds capable of regulating the expression of a gene that inhibits collagen synthesis may be useful for modulating a fibrotic process or treating a fibrotic condition.